UK clinical trials - updated daily from ClinicalTrials.gov
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Clinical Trial Phases Explained: Comparing Clinical Trials in the UK

Understand the key differences between phase 1 & 2 and phase 3 & 4 clinical trials and research opportunities

Overview

Phase 1 & 2

Phase 1 tests safety and dosing in small groups (20-100 people). Phase 2 tests efficacy and side effects in larger groups (100-300). Both carry higher uncertainty but offer access to novel treatments.

UK Trials Recruiting: ~800+ recruiting

Phase 3 & 4

Phase 3 compares new treatments to standard of care in large groups (300-3,000+). Phase 4 monitors long-term safety after approval. Phase 3 provides the strongest evidence.

UK Trials Recruiting: ~400+ recruiting

Key Differences for Trial Seekers

Earlier phases offer novel treatments but with more uncertainty about benefit. Phase 3 trials provide the most reliable evidence and are closer to changing standard practice.

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Data sourced from ClinicalTrials.gov. Trial counts are approximate and updated regularly.

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