UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for Chronic Obstructive Pulmonary Disease (COPD) in the United Kingdom. Explore treatment pathways from early to severe disease.
COPD affects ~1.2 million people in the UK, though many are undiagnosed. It's caused primarily by smoking and involves progressive narrowing of the airways. While lung damage can't be reversed, treatment can significantly improve symptoms and slow progression. Early diagnosis and quitting smoking are the most important steps.
Treatment follows a stepwise approach based on severity and exacerbation frequency. Mild: short-acting bronchodilators (salbutamol). Moderate: long-acting bronchodilators (LAMA and/or LABA). Severe or frequent exacerbations: triple therapy (LAMA + LABA + ICS). Very severe: may include oxygen therapy, pulmonary rehabilitation, and lung volume reduction.
Active COPD research areas in the UK include: new long-acting bronchodilators, anti-inflammatory biologics (benralizumab, dupilumab), lung volume reduction (endobronchial valves), stem cell therapies, pulmonary rehabilitation innovations, and digital health monitoring. The NHS has dedicated COPD clinical networks for trial recruitment.
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