UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for sleep disorders in the United Kingdom. Explore studies for insomnia, sleep apnoea, narcolepsy, and circadian rhythm disorders — including paid healthy volunteer trials.
Sleep disorders affect up to 16 million UK adults, with insomnia being the most common. Obstructive sleep apnoea (OSA) affects ~1.5 million, most undiagnosed. The UK has excellent sleep research facilities at university sleep labs (Surrey, Edinburgh, Oxford, Manchester) and dedicated clinical trial units. Sleep studies are popular with healthy volunteers because they often involve comfortable overnight stays with monitoring equipment.
University sleep lab studies: healthy volunteers undergo sleep monitoring (EEG, ECG, oxygen) to test effects of medications, light exposure, or sleep schedules. Compensation: £100-£500 per night. Phase 1 drug studies: testing new insomnia medications (dual orexin receptor antagonists like daridorexant, lemborexant), stay-awake drugs for narcolepsy, and new formulations. Compensation: £500-£3,000. CPAP and device studies for sleep apnoea patients: testing new devices, masks, and monitoring technology.
Insomnia: CBT-I is first-line treatment. Medications include Z-drugs (zolpidem, zopiclone), melatonin, and newer dual orexin receptor antagonists (daridorexant/Quviviq, lemborexant/Dayvigo). Sleep apnoea: CPAP is standard, with new options including hypoglossal nerve stimulation, oral appliances, and positional therapy. Narcolepsy: modafinil, sodium oxybate, and newer treatments like pitolisant and solriamfetol.
Active UK sleep trials include: next-generation orexin receptor antagonists, novel melatonin formulations, digital therapeutics for insomnia (CBT-I apps with clinical validation), sleep apnoea device innovations, circadian rhythm studies (shift workers, jet lag), and narcolepsy drug development. University sleep labs in Surrey, Edinburgh, and Manchester regularly recruit healthy volunteers for paid sleep studies.
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