At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Not specified by the sponsor
- How long the study runs
- Study runs about 172 months (dates as stated)
- About the drug or intervention
- Not specified by the sponsor
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Observing health over time
- Ages
- 18 Years to 80 Years
- Who
- All
- Number of participants
- 150
- Started
- 2014-05-16
- Last checked
- 2026-05
Plain English Summary
What is this study?
- • Testing a new treatment for health
- • Clinical study - 150 participants
- • Patients with high blood pressure (hypertension) and chronic kidney disease are at an increased risk of developing heart disease and strokes
Who can take part?
- • Ages 18 Years to 80 Years
- • Diagnosed with health
Where?
- • Edinburgh - University of Edinburgh
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Patients with high blood pressure (hypertension) and chronic kidney disease are at an increased risk of developing heart disease and strokes. Part of this risk is due to changes in the structure and function of the blood vessels throughout the body. It is thought that reducing high blood pressure and treating chronic kidney disease improves the structure and function of blood vessels but information on this is limited. Optical coherence tomography (OCT) is a method of looking at the blood vessels at the back of the eye. It is a simple, quick and non-invasive test that you may have previously had during a visit to the optician. The purpose of the study is to ascertain whether OCT is able to detect changes in the eye's blood vessels in patients with hypertension and chronic kidney disease compared to healthy individuals and also to see if any differences seen improve with treatment.
More detail
This project is an exploratory study, using enhanced depth imaging with the new SPECTRALIS OCT, designed to examine choroidal and microvascular retinal structure in patients with hypertension, chronic kidney disease (CKD), and in age and sex matched healthy controls. The study is non-invasive and takes only a few seconds to acquire these complex images. The Centre, where the images will be captured and where image analysis systems are located, is on the Royal Infirmary of Edinburgh (RIE) site close to the RIE outpatient clinics, making recruitment easy.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years - 80 Years
- Who can join: All genders
What the study is looking for
- ✓Male or female
- ✓Age 18-80
- ✓Body mass index ≤35
- ✓For those with hypertension: BP ≥140/90 or on treatment for hypertension
- ✓For those with CKD: CKD as defined by the Kidney Diseases Quality Initiative guidelines
Who cannot take part
- ✗Subject is below the age of legal consent, or is mentally or legally incapacitated
- ✗The subject has donated blood (450 ml) within the last 4 weeks
- ✗Past or present drug or alcohol abuse including intravenous drug abuse at any time
- ✗Participation in another clinical trial within 1 month
- ✗Considered to be at high risk of HIV or hepatitis B
See the full criteria
Where Is This Study? (1 UK site)
University of Edinburgh
Edinburgh EH164TJ, United Kingdom
How to Get in Touch
Neeraj Dhaun, MD PhD
Sponsor contactCONTACT
David Webb
Sponsor contactCONTACT