At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Preoperative MRI scan (other)
- How long the study runs
- Study runs about 208 months (dates as stated)
- About the drug or intervention
- Preoperative MRI scan — other: Standard preoperative CT of abdomen, chest and pelvis plus interventional preoperative MRI scan.
- Patient visit burden
- Not specified by the sponsor
In plain English
This study, run by Imperial College London, looks at whether MRI (magnetic resonance imaging, a scan that uses magnets instead of X-rays) scans can help improve treatment for people with cancer of the sigmoid colon (the lower part of the large bowel). The aim is for the scan to be reviewed by a team of doctors before surgery so decisions about treatment can be better planned. Further detail on the study's methods is not stated — ask the trial team.
Who can take part
- You have a suspected or confirmed cancer of the sigmoid colon (an adenocarcinoma)
- You are able to have treatment that aims to cure the cancer
- Your cancer has not spread in a way that cannot be removed by surgery
- Your MRI scan can be reviewed by a team of specialists (an MDT, or multidisciplinary team) before surgery
- No decision has yet been made about your major (radical) treatment
- You have given written informed consent to take part
- You are aged 16 or over
Who may not be able to
- Your cancer has spread to other parts of the body (including spread to the liver that could be removed)
- You have a second cancer at the same time
- You cannot have an MRI scan (for example, for medical reasons)
- You cannot have, or are allergic to, Buscopan (a medicine used during the scan) — for example because of glaucoma, a blocked bowel, or very poor kidney function
- You have serious other health problems or a medical history that would prevent chemotherapy or radiotherapy if needed
What taking part involves
- • Having an MRI scan that is reviewed by a specialist team before surgery
- • Not stated — ask the trial team about any other tests or procedures involved
Time commitment: Not stated — ask the trial team about how many visits are needed, how long the study lasts, and exactly what taking part involves.
Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.
- Type of study
- Testing a treatment
- Ages
- 16 Years and over
- Who
- All
- Number of participants
- 244
- Started
- 2014-08
- Last checked
- 2024-10
Plain English Summary
What is this study?
- • Testing a new treatment for cancer
- • NA - 244 participants
- • Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible
Who can take part?
- • Ages 16 Years and over
- • Diagnosed with cancer
Where?
- • Huntingdon - Hinchingbrooke Hospital
- • Crewe - Leighton Hospital
- • Stockton-on-Tees - University Hospital of North Tees
- • Thornton Heath - Croydon University Hospital
- • +12 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible. Patient are randomised to the control arm which the standard care of preoperative CT imaging and subsequent discussion by the Multidisciplinary Team or the interventional arm which has the additional use of MRI imaging and subsequent discussion by the Multidisciplinary Team. Patients are followed up at 1 and 3 years together with QoL questionnaires.
More detail
A randomised phase II multicentre trial, IMPRESS will determine whether the use of MRI imaging in staging sigmoid cancers results in a change to the treatment plan by identifying more high risk tumours compared to those patients who were staged using CT imaging. The proposed intervention will be additional radiological and pathological assessment and the reporting of supplementary diagnostic information which would not otherwise have been available. This may affect treatment according to local MDT protocols and also affect the provision of prognostic information to patients in subsequent discussions.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 16 Years and over
- Who can join: All genders
What the study is looking for
- ✓Have a suspected or proven sigmoid colon adenocarcinoma
- ✓Is eligible for curative treatment
- ✓Has no irresectable that has spread disease
- ✓MRI can be reviewed by an MDT prior to surgery
- ✓Has no decision regarding radical treatment
Who cannot take part
- ✗Have that has spread disease (including resectable liver metastases)
- ✗Have a synchronous second cancer
- ✗Are not safe to use for MRI
- ✗Are not safe to use for or have allergy to Buscopan (e.g. glaucoma, small or large bowel obstruction, GFR\<30)
- ✗Have severe co-morbidities or previous medical history that prevent the application of eventual chemo/radiotherapy
See the full criteria
Where Is This Study? (16 UK sites)
Hinchingbrooke Hospital
Huntingdon PE29 6NT, United Kingdom
Leighton Hospital
Crewe CW1 4QJ, United Kingdom
University Hospital of North Tees
Stockton-on-Tees TS19 8PE, United Kingdom
Croydon University Hospital
Thornton Heath CR7 7YE, United Kingdom
Chesterfield Royal
Chesterfield SS4 5BL, United Kingdom
Queen Alexandra Hospital
Portsmouth PO6 3LY, United Kingdom
St Mark's Hospital
Middlesex HA1 3UJ, United Kingdom
Maidstone Hospital
Maidstone ME16 9QQ, United Kingdom
Queen Elizabeth the Queen Mother Hospital
Margate CT9 4AN, United Kingdom
North Manchester General Hospital
Crumpsall M8 5RB, United Kingdom
University Hospital of South Manchester & Manchester Royal Infirmary
Wythenshawe M23 9LT, United Kingdom
Harrogate District Hospital
Harrogate HG2 7SX, United Kingdom
Musgrove Park Hospital
Taunton TA1 5DA, United Kingdom
Yeovil District Hospital
Yeovil BA21 4AT, United Kingdom
Royal Marsden Hospital
Sutton SM2 5PT, United Kingdom
Salisbury District Hospital
Salisbury SP2 8BJ, United Kingdom
How to Get in Touch
Caroline Martin
Sponsor contactCONTACT
Syvella Ellis
Sponsor contactCONTACT