At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Not specified by the sponsor
- How long the study runs
- Study runs about 164 months (dates as stated)
- About the drug or intervention
- Not specified by the sponsor
- Patient visit burden
- Not specified by the sponsor
In plain English
This study looks at how well cardiopulmonary resuscitation (CPR, meaning pushes on the chest to help the heart and blood flow) is carried out when a child's heart stops, across several hospitals working together. It covers babies born after at least 37 weeks of pregnancy through to young people aged up to 18. The study is run by the Children's Hospital of Philadelphia.
Who can take part
- The patient received chest compressions for at least 1 minute.
- The patient is between a baby born after at least 37 weeks of pregnancy and 18 years of age.
Who may not be able to
- The patient was already on a heart-lung support machine called veno-arterial extracorporeal membrane oxygenation (ECMO) when the CPR began.
What taking part involves
- • Not stated — ask the trial team
Time commitment: Not stated — ask the trial team.
Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.
- Type of study
- Observing health over time
- Ages
- 0 Years to 18 Years
- Who
- All
- Number of participants
- 7,000
- Started
- 2016-05-02
- Last checked
- 2025-09
Plain English Summary
What is this study?
- • Testing a new treatment for cardiac arrest
- • Clinical study - 7,000 participants
- • This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests
Who can take part?
- • Ages 0 Years to 18 Years
- • Diagnosed with cardiac arrest
Where?
- • London - Great Ormond Street Hospital
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
More detail
Cardiac arrests in children are a major public health problem. Thousands of children each year in the USA are treated with cardiopulmonary resuscitation (CPR) and managed after their cardiac arrest. Neurological outcomes following these in-hospital CPR events are often abnormal. As children with neurological deficits following CPR are a major burden for families and society, improving neurological outcomes through superior chest compression delivery during CPR and optimal care and management after cardiac arrest is an important clinical goal. Therefore, the objective of this investigation is to obtain evidentiary support to associate the relationship of quantitative CPR quality data (depth, rate, chest compressions (CC) fraction, compression release) during CPR, post-cardiac arrest care (PCAC) and patient survival in those children who suffer an arrest within the study (RES-Q) Network.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 0 Years - 18 Years
- Who can join: All genders
What the study is looking for
- ✓Patient received chest compressions for at least 1 minute
- ✓Patient between gestational age ≥37 weeks and 18 years of age
Who cannot take part
- ✗Patient on veno-arterial extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event
See the full criteria
Where Is This Study? (1 UK site)
Great Ormond Street Hospital
London WC1N 3JH, United Kingdom
Main Email: Research.Governance@gosh.nhs.uk
Research.Governance@gosh.nhs.uk0207 905 2700How to Get in Touch
Vinay Nadkarni, MD, MS
Sponsor contactCONTACT
Kathryn Graham
Sponsor contactCONTACT