At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Default dialysate sodium concentration of 137mmol/l (other), Default dialysate sodium concentration of 140mmol/l (other)
- How long the study runs
- Study runs about 126 months (dates as stated)
- About the drug or intervention
- Default dialysate sodium concentration of 137mmol/l — other: Default defined here as use of allocated dialysate sodium concentration for at least 90% of delivered dialysis sessions. · Default dialysate sodium concentration of 140mmol/l — other: Default defined here as use of allocated dialysate sodium concentration for at least 90% of delivered dialysis sessions.
- Patient visit burden
- Not specified by the sponsor
In plain English
This study looks at end-stage kidney disease and whether different sodium levels in the fluid used during haemodialysis (a treatment that filters the blood when the kidneys no longer work) affect the risk of problems with blood vessels. It is sponsored by the University of Sydney.
Who can take part
- Adults aged 18 or over who receive regular haemodialysis at a dialysis unit taking part in the study
- The dialysis unit must usually use one standard sodium level in the dialysis fluid for most sessions
- The dialysis unit must be willing to be randomly assigned (by chance) to either study group
- The unit must have at least 10 people on dialysis when it joins the study
Who may not be able to
- People who cannot follow the study's data collection methods
- Home dialysis training or support units (though units with both in-centre and home patients can take part, with only in-centre patients included)
What taking part involves
- • Not stated — ask the trial team
Time commitment: Not stated — ask the trial team about what taking part involves, including visits and how long the study lasts.
Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 50,000
- Started
- 2016-06
- Last checked
- 2025-04
Plain English Summary
What is this study?
- • Testing a new treatment for end-stage kidney disease
- • Phase4 - 50,000 participants
- • This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with end-stage kidney disease
Where?
- • Altrincham - Altrincham General Hospital Dialysis Unit
- • Ashton-under-Lyne - Tameside Renal Dialysis Unit
- • Barnet - Barnet Satellite Unit
- • Barnsley - Barnsley Dialysis Unit
- • +91 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis.
More detail
RESOLVE is a pragmatic, cluster-randomised, open-label study designed to evaluate in real-world conditions the comparative effectiveness of two default dialysate sodium concentrations. Dialysis sites will be randomised in a 1:1 ratio to a default dialysate sodium concentration of 137mmol/l or 140mmol/l. 'Default' is defined as the use of the allocated dialysate sodium for ≥ 90% of delivered dialysis sessions in the unit. All other care will be according to standard local practices as determined by the site. Outcomes will be assessed on individual patients dialysing at those sites. Sites will be asked to consent to participation while waiver or opt-out consent will be sought for individual patients. It is anticipated that site accrual will occur over 5-7 years with average study duration expected to be approximately 2-5 years. The actual length of the study will be end-point determined.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓The site inclusion criteria are:
- ✓Predominantly dialyses adults (≥18 years old) receiving maintenance haemodialysis
- ✓Rates of withdrawal within the first two years of commencing dialysis for social reasons have been less than 15% for...
- ✓Has a minimum of 10 dialysis recipients at time of randomisation
- ✓Utilises a default dialysate sodium concentration at the time of recruitment (a substantial majority of dialysis...
See the full criteria
Where Is This Study? (95 UK sites)
Altrincham General Hospital Dialysis Unit
Altrincham, United Kingdom
Tameside Renal Dialysis Unit
Ashton-under-Lyne, United Kingdom
Barnet Satellite Unit
Barnet, United Kingdom
Barnsley Dialysis Unit
Barnsley, United Kingdom
Bath Dialysis Unit
Bath, United Kingdom
Professor Julie Barnett (Associate Pro Vice-Chancellor, Research)
pro-vc-research@bath.ac.uk1225383162Bedford Renal Unit
Bedford, United Kingdom
Bexhill Dialysis Unit
Bexhill-on-Sea, United Kingdom
Hexagon Towers Dialysis Unit
Blackley, United Kingdom
Bolton Kidney Care Centre
Bolton, United Kingdom
Alison Loftus. R&D Co-ordinator
alison.loftus@boltonft.nhs.uk01204 390390 ext. 3848St Luke's Hospital Renal Ward
Bradford, United Kingdom
Bridgwater Dialysis Unit
Bridgwater, United Kingdom
Brighton Sussex Kidney Unit
Brighton, United Kingdom
Cossham Dialysis Unit
Bristol, United Kingdom
South Bristol Dialysis Unit
Bristol, United Kingdom
Bromley Dialysis Unit
Bromley, United Kingdom
Broomfield Hospital
Broomfield, United Kingdom
Main Email: mse.lehprimarycareresearch@nhs.net
mse.lehprimarycareresearch@nhs.net01245 516339Cannock Haemodialysis Unit
Cannock, United Kingdom
Chesterfield Dialysis Unit
Chesterfield, United Kingdom
Clacton (Diaverum)
Clacton-on-Sea, United Kingdom
Colchester (Diaverum)
Colchester, United Kingdom
Clay Lane
Coventry, United Kingdom
University Hospitals Coventry & Warwickshire Main Unit
Coventry, United Kingdom
Crawley Dialysis Unit
Crawley, United Kingdom
Leighton
Crewe, United Kingdom
Cromer Hospital Dialysis Unit
Cromer, United Kingdom
Darlington Dialysis Unit
Darlington, United Kingdom
Dartford Dialysis Unit
Dartford, United Kingdom
Dover Renal Unit
Dover, United Kingdom
Edgware Satellite Unit
Edgware, United Kingdom
Epsom Dialysis Unit
Epsom, United Kingdom
Heavitree
Exeter, United Kingdom
Farnborough Dialysis Unit
Farnborough, United Kingdom
Cotswold Dialysis Centre
Gloucester, United Kingdom
Severn
Gloucester, United Kingdom
James Paget Renal Unit
Great Yarmouth, United Kingdom
Grimsby Renal Unit
Grimsby, United Kingdom
Harlow Renal Unit
Harlow, United Kingdom
Hayes Hospital
Hayes, United Kingdom
Honiton
Honiton, United Kingdom
Chiltern Renal Unit
Houghton Regis, United Kingdom
Fresenius Hull Dialysis Unit
Hull, United Kingdom
James Illingworth
hyp-tr.development.research@nhs.net01482 461883 or 461903West Middlesex
Isleworth, United Kingdom
Kingston Satellite Dialysis Unit
Kingston, United Kingdom
Collierswood Dialysis Unit
London, United Kingdom
King George Hospital
London, United Kingdom
Mary Rankin Satellite Unit
London, United Kingdom
North Wandsworth Dialysis Unit
London, United Kingdom
Royal London Hospital
London, United Kingdom
Whipps Cross Hospital
London, United Kingdom
Ludlow Dialysis Unit
Ludlow, United Kingdom
Macclesfield District General Hospital
Macclesfield, United Kingdom
Head of Clinical Governance
ecn-tr.ResearchandDevelopment@nhs.net01625 661018Manchester Royal Infirmary Renal Dialysis Unit
Manchester, United Kingdom
Octagon Renal Satellite
Manchester, United Kingdom
Margate Renal Unit
Margate, United Kingdom
James Cook
Middlesbrough, United Kingdom
North Ormesby
Middlesbrough, United Kingdom
Harrogate
North Yorks, United Kingdom
Friarage Hospital
Northallerton, United Kingdom
Lucy Deane (George Eliot)
Nuneaton, United Kingdom
Oldham Dialysis Unit
Oldham, United Kingdom
Newham Hospital
Plaistow, United Kingdom
Eastbourne (Polegate) Dialysis Unit
Polegate, United Kingdom
Rochdale Dialysis Unit
Rochdale, United Kingdom
Queen's Hospital
Romford, United Kingdom
Rotherham Dialysis Unit
Rotherham, United Kingdom
St Cross (Ash Unit)
Rugby, United Kingdom
Salford Renal Unit
Salford, United Kingdom
Scarborough
Scarborough, United Kingdom
Scunthorpe Dialysis Centre
Scunthorpe, United Kingdom
Peter Moorhead Unit
Sheffield, United Kingdom
Renal G Floor
Sheffield, United Kingdom
Sheffield Dialysis Unit
Sheffield, United Kingdom
Shrewsbury Renal Unit
Shrewsbury, United Kingdom
Smethwick Dialysis Centre
Smethwick, United Kingdom
St Albans Dialysis Unit
St Albans, United Kingdom
County Hospital
Stafford, United Kingdom
Anthony Homer. Research Governance Manager
Research@dchft.nhs.uk01305 253 127Lister Renal Unit
Stevenage, United Kingdom
Stockport NHS Dialysis Unit
Stockport, United Kingdom
Research, Development & Innovation Office
research.development@stockport.nhs.uk0161 419 5893North Tees
Stockton-on-Tees, United Kingdom
Research and Development
nth-tr.ntandh.researchdevelopment@nhs.net01642 624090Royal Stoke
Stoke-on-Trent, United Kingdom
Stratford Dialysis Centre
Stratford-upon-Avon, United Kingdom
St. Helier Dialysis Unit
Sutton, United Kingdom
Sutton Dialysis Unit
Sutton, United Kingdom
Taunton Dialysis Centre
Taunton, United Kingdom
Hollinswood House Renal Unit
Telford, United Kingdom
Croydon Dialysis Unit
Thornton Heath, United Kingdom
Non Portfolio - Michael Chang Portfolio - South West Cluster Office
ch-tr.research@nhs.net0208 401 3610South Devon Satellite Kidney Unit
Torquay, United Kingdom
Tottenham Hale Satellite Unit
Tottenham, United Kingdom
Wigan Renal Unit
Wigan, United Kingdom
Ashford Renal Unit
Willesborough, United Kingdom
Pond Lane Dialysis Unit
Wolverhampton, United Kingdom
Woolwich Dialysis Unit
Woolwich, United Kingdom
Worthing Dialysis Unit
Worthing, United Kingdom
Easingwold
York, United Kingdom
York Hospital
York, United Kingdom
How to Get in Touch
Grace Balicki
Sponsor contactCONTACT
Erika Dempsey
Sponsor contactCONTACT