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Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy

Sponsor: University Hospitals of Derby and Burton NHS Foundation Trust

NCT ID: NCT04109079

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Axillary lymph node dissection (procedure), Axillary radiotherapy (radiation), Breast or chest wall radiotherapy (radiation)
How long the study runs
Study runs about 108 months (dates as stated)
About the drug or intervention
Axillary lymph node dissection — procedure: Participants will undergo removal of at least level I and II axillary lymph nodes. · Axillary radiotherapy — radiation: Axillary radiotherapy will be delivered as per the Radiotherapy Trials Quality Assurance (RTTQA) guidelines. · Breast or chest wall radiotherapy — radiation: Breast or chest wall radiotherapy will be delivered as per the Radiotherapy Trials Quality Assurance (RTTQA) guidelines.
Patient visit burden
Not specified by the sponsor

In plain English

This study is for people with breast cancer that had spread to lymph nodes (glands) under the arm, confirmed by a needle biopsy, before chemotherapy. Everyone in the study had chemotherapy before surgery, and the trial looks at how the armpit lymph nodes were managed after treatment. It is sponsored by University Hospitals of Derby and Burton NHS Foundation Trust.

Who can take part

  • Adults aged 18 or over, male or female
  • Breast cancer diagnosed as cT1-3N1M0 (a certain stage of breast cancer) before chemotherapy, using AJCC 8th edition staging
  • People with no obvious cancer in the breast itself, but with cancer spread to armpit nodes proven by needle biopsy, can also take part
  • Cancer spread to armpit lymph nodes confirmed by fine needle aspiration (FNA) or core biopsy before treatment
  • Hormone receptor (oestrogen receptor) and HER2 status tested on the main tumour
  • Received standard chemotherapy before surgery (neoadjuvant chemotherapy, or NACT) — people having hormone therapy before surgery as part of another trial can also take part
  • Had scans of the armpit to check how the cancer responded to chemotherapy
  • Had a sentinel lymph node biopsy (removal of the first lymph nodes cancer would spread to) after chemotherapy, using two tracers (dyes), with at least 3 nodes removed
  • If only one tracer was used: the affected node must have been marked before or during chemotherapy, and at least 3 nodes (including the marked one) removed
  • If the node was not marked or the marked node was not removed: the tissue report must show signs the cancer responded (e.g. scarring or fibrosis) in at least one node, with at least 3 nodes removed
  • If fewer than 3 nodes were found: the affected node must have been marked and removed, and that node must show signs of response such as scarring
  • If the sentinel node could not be found, a sample of armpit nodes must have been taken, with at least 3 nodes removed
  • No signs of cancer in the lymph nodes after chemotherapy (no isolated tumour cells, micro or macro metastasis)
  • People whose lymph nodes fully cleared but who still had some cancer left in the breast can take part
  • People who had no cancer in their nodes at the start but whose sentinel node after chemotherapy was clear and showed signs of response, with at least 3 nodes removed, can take part

Who may not be able to

  • Cancer in both breasts at the same time
  • Sentinel lymph node biopsy before chemotherapy
  • Previous lymph node surgery in the same armpit as the planned sampling
  • Any other cancer in the last 5 years, or another cancer at the same time — except some skin cancers, early cervical cancer, early melanoma, non-invasive breast cancer, or chronic lymphocytic leukaemia not on treatment

What taking part involves

  • • Chemotherapy before surgery (neoadjuvant chemotherapy, or NACT) given as standard care
  • • Sentinel lymph node biopsy after chemotherapy, using tracers to find the nodes, with at least 3 nodes removed
  • • In some cases, marking of the affected node before or during chemotherapy so it can be found and removed
  • • If the sentinel node cannot be found, a sample of armpit lymph nodes is taken instead

Time commitment: Not stated — ask the trial team.

Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.

Type of study
Testing a treatment
Ages
18 Years and over
Who
All
Number of participants
1,900
Started
2021-02-26
Last checked
2026-03

Plain English Summary

What is this study?

  • • Testing a new treatment for breast cancer
  • • NA - 1,900 participants
  • • The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in the lymph nodes on sentinel node biopsy, is non-inferior to axillary treatment in terms of disease free survival (DFS) and results in reduced risk of lymphoedema at 5 years

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with breast cancer

Where?

  • • Keighley - Airedale General Hospital - Airedale NHS Foundation Trust
  • • Carlisle - Cumberland Infirmary - North Cumbria Integrated Care NHS Foundation Trust
  • • Camberley - Frimley Park Hospital - Frimley Health NHS Foundation Trust
  • • Inverness - Raigmore Hospital - NHS Highland
  • • +90 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in the lymph nodes on sentinel node biopsy, is non-inferior to axillary treatment in terms of disease free survival (DFS) and results in reduced risk of lymphoedema at 5 years.

More detail

Background: The presence of cancer in the axillary lymph nodes on needle biopsy in patients with early stage breast cancer before neoadjuvant chemotherapy (NACT) has been the determinant of the need for axillary treatment (in the form of axillary lymph node dissection (ALND) or axillary radiotherapy (ART)) after completion of NACT. Treatment to the axilla damages lymphatic drainage from the arm and patients can subsequently develop lymphoedema, restricted shoulder movement, pain, numbness, and other sensory problems. As more effective chemotherapy is now available that results in complete eradication of cancer in the axilla in around 40 to 70% of patients, extensive axillary treatment might no longer be necessary in patients with no evidence of residual nodal disease. Aim: To assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in the lymph nodes on sentinel node biopsy, is non-inferior to axillary treatment in terms of disease free survival (DFS) and results in reduced risk of lymphoedema at 5 years. Methods: Study design: A pragmatic, phase 3, open, randomised, multicentre trial and embedded economic evaluation in which participants will be randomised in a 1:1 ratio. Study population: T1-3N1M0 breast cancer patients aged 18 years or older, with needle biopsy proven nodal metastases, who after NACT have no residual cancer in the lymph nodes on dual tracer sentinel node biopsy and removal of at least 3 lymph nodes (sentinel nodes and marked involved node). Intervention: All participants will receive human epidermal growth factor receptor 2 (HER2)-targeted treatment, endocrine therapy and radiotherapy to breast or chest wall, if indicated according to local guidelines. Patients in the intervention group will not receive further axillary treatment (ALND or ART), whereas those receiving standard care will receive axillary treatment (ALND or ART) as per local guidelines. Follow-up is annually for at least 5 years. Outcomes: The co-primary outcomes are disease free survival(DFS) and self-reported lymphoedema defined as 'yes' to the two questions participants will be asked - 'arm heaviness during the past year' and 'arm swelling now' from the Lymphoedema and Breast Cancer Questionnaire at 5 years. Secondary outcomes: arm function assessed by the QuickDASH (disabilities of the arm, shoulder and hand) questionnaire; health related quality of life assessed using euroqol EQ-5D-5L; axillary recurrence free interval (ARFI); local recurrence; regional (nodal) recurrence; distant metastasis; overall survival; contralateral breast cancer; non-breast malignancy; costs; quality adjusted life years (QALYs) and cost-effectiveness. Sample size: A sample size of 1900 patients would have the ability to demonstrate a 3.5% non-inferiority margin with a 5% 1-sided significance level and 85% power, allowing for 7% non-collection of primary outcome data assuming a 90% 5-year disease free survival rate in the control arm. It would also be able to detect at least a 5% difference in proportion of patients with lymphoedema with 90% power, a 5% 2-sided significance level and allowing for 25% non-collection of primary outcome data over 5 years. Analysis plan: All analyses will be carried out on an intention-to-treat basis to preserve randomisation, avoid bias from exclusions and preserve statistical power. Time to event outcomes, including disease free survival and axillary recurrence free interval, will be assessed using Kaplan-Meier curves and compared using Cox proportional hazards models. The proportion of patients experiencing lymphoedema at 5 years will be compared across trial arms using a chi-squared test and a logistic regression model used to adjust for stratification variables. Arm morbidity and health related quality of life will be scored using the appropriate manuals and assessed using a longitudinal mixed model regression analysis if model assumptions valid or a standardised area-under-the-curve analysis. For economic evaluation, incremental cost per QALY gained at 5 years will be estimated. Timelines for delivery: Total project duration is 120 months based on 6 months for set up; 60 months recruitment period (including an 18 months internal pilot phase); and 54 months for follow up, analysis, writing up and dissemination.

Breast CancerSentinel Lymph NodeNeoplasm, Breast

How this trial compares with your answers

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What we know so far

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

Biomarkers mentioned

HER2metnode negativewith a negative

What the study is looking for

  • ✓Age ≥ 18
  • ✓Male or female
  • ✓cT1-3N1M0 breast cancer at diagnosis (prior to NACT) as per AJCC 8th edition (see Section 6.4.1)
  • ✓o Patients with occult primary invasive breast cancer (no identifiable invasive cancer in the breast) with FNA or...
  • ✓FNA or core biopsy confirmed axillary nodal metastases at presentation
See the full criteria
Inclusion Criteria: * Age ≥ 18 * Male or female * cT1-3N1M0 breast cancer at diagnosis (prior to NACT) as per AJCC 8th edition (see Section 6.4.1) o Patients with occult primary invasive breast cancer (no identifiable invasive cancer in the breast) with FNA or core biopsy proven nodal metastases are eligible for the study. * FNA or core biopsy confirmed axillary nodal metastases at presentation * Oestrogen receptor and HER2 status evaluated on primary tumour * Received standard NACT as per local guidelines (Patients undergoing neoadjuvant endocrine therapy as part of another clinical trial are eligible) * Imaging of the axilla, as required, to assess response to NACT (per local guidelines) * Undergo a dual tracer sentinel node biopsy (SNB) after NACT with at least 3 nodes removed. * If a single tracer SNB is performed: the patient is eligible only if the involved node is marked before or during NACT, and at least 3 nodes (including the marked node) are removed during sentinel node biopsy. * If the node is not marked or the marked node is not removed: the patient is eligible only if the histology report shows evidence of down-staging with complete pathological response e.g., fibrosis or scarring in at least one node and at least 3 nodes removed. * If fewer than 3 nodes are found on histology: the patient is eligible only if BOTH points a) and b), below, are met: 1. involved node was marked and removed during SNB; and 2. removed marked node shows evidence of downstaging on histology e.g. fibrosis or scarring. * If the sentinel node(s) cannot be localised on SNB: axillary node sampling should be performed, the patient will be eligible if at least 3 nodes are removed. * No evidence of nodal metastases post NACT (isolated tumour cells, micro or macro metastasis) * Patients with complete pathological response in the axilla but residual disease in the breast post NACT are eligible for the study * Patients who are cN0 (node negative) at initial presentation, with a negative sentinel node post NACT showing evidence of treatment response or downstaging will be eligible, provided at least 3 nodes are removed. 5.2. Exclusion Criteria Participants will be excluded if they have any one of the following: * Bilateral synchronous invasive breast cancer * Sentinel node biopsy prior to NACT * Previous axillary nodal surgery on the same body side as the scheduled targeted sampling * Any previous cancer within last 5 years or concomitant malignancy except * basal or squamous cell carcinoma of the skin * in situ carcinoma of the cervix * in situ or stage 1 melanoma * contra- or ipsilateral in situ breast cancer * chronic lymphocytic leukaemia not on treatment

Where Is This Study? (94 UK sites)

Airedale General Hospital - Airedale NHS Foundation Trust

Keighley, United Kingdom

Recruiting
Hospital R&D contact (matched)

Mechele Couch-Upite

anhsft.researchanddevelopment@nhs.net01535 292278 / 01535 294655

Cumberland Infirmary - North Cumbria Integrated Care NHS Foundation Trust

Carlisle, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research and Development Team research@ncic.nhs.uk

nencadmin@nihr.ac.uk01228 523444

Frimley Park Hospital - Frimley Health NHS Foundation Trust

Camberley, United Kingdom

Recruiting
Hospital R&D contact (matched)

Clare Denford

fhft.research-innovation@nhs.net0300 613 2301

Raigmore Hospital - NHS Highland

Inverness, United Kingdom

Recruiting

James Paget Hospital -James Paget University Hospitals NHS Foundation Trust

Great Yarmouth, United Kingdom

Recruiting
Hospital R&D contact (matched)

rd.office@jpaget.nhs.uk

rd.office@jpaget.nhs.uk01493 453478

Royal Berkshire Hospital - Royal Berkshire NHS Foundation Trust

Reading, United Kingdom

Recruiting
Hospital R&D contact (matched)

Leslie Frederick-Mokogwu

researchanddevelopment@royalberkshire.nhs.uk0118 322 7449

Macclesfield District General Hospital - East Cheshire NHS Trust

Macclesfield, United Kingdom

Recruiting
Hospital R&D contact (matched)

Head of Clinical Governance

ecn-tr.ResearchandDevelopment@nhs.net01625 661018

Royal Shrewsbury Hospital -The Shrewsbury and Telford Hospitals NHS Trust

Shrewsbury, United Kingdom

Recruiting
Hospital R&D contact (matched)

Joanne Sawyer, Head of R&I

Sath.research@nhs.net01743 261000 ext 1646

Aberdeen Royal Infirmary - NHS Grampian

Aberdeen AB25 2ZN, United Kingdom

Recruiting
Hospital R&D contact (matched)

Fiona Brebner

gram.randd@nhs.scot01224 551121

Ashford Hospital - Ashford and St Peter's Hospitals NHS Foundation Trust

Ashford TW15 3AA, United Kingdom

Recruiting
Hospital R&D contact (matched)

Freda Gomes

asp-tr.research@nhs.net01932 723534

Tameside General Hospital- Tameside and Glossop Integrated Care NHS Foundation Trust

Ashton-under-Lyne OL6 9RW, United Kingdom

Recruiting
Hospital R&D contact (matched)

Rebecca Roberts

rebecca.roberts@tgh.nhs.uk0161 922 4451

University Hospital Crosshouse - NHS Ayrshire and Arran

Ayr KA6 6DX, United Kingdom

Recruiting
Hospital R&D contact (matched)

Karen Bell

karen.bell2@aapct.scot.nhs.uk01563 825850

Basildon University Hospital - Mid and South Essex NHS Foundation Trust

Basildon SS16 5NL, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr Sam Hayton

mse.researchenquiries@nhs.net---

Belfast City Hospital - Belfast Health and Social Care Trust

Belfast BT9 7AB, United Kingdom

Recruiting
Hospital R&D contact (matched)

Alison Murphy

alison.murphy@belfasttrust.hscni.net028 9063 6366

QEHB- University Hospitals Birmingham NHS Foundation Trust

Birmingham B15 2GW, United Kingdom

Recruiting
Hospital R&D contact (matched)

Sarah Pountain Head of Research Governance

R&D@uhb.nhs.uk0121 371 4185

City Hospital -Sandwell and West Birmingham NHS Trust

Birmingham B18 7QH, United Kingdom

Recruiting
Hospital R&D contact (matched)

Zaida Khalil

swbh.randd.generic@nhs.net0121 507 4092

Blackpool Victoria Hospital - Blackpool Teaching Hospitals NHS Foundation Trust

Blackpool, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr Angela Parker

bfwh.randd.office@nhs.net01253 (9) 51514 / (9) 55547

Royal Bolton Hospital - Bolton NHS Foundation Trust

Bolton BL4 0JR, United Kingdom

Recruiting
Hospital R&D contact (matched)

Alison Loftus. R&D Co-ordinator

alison.loftus@boltonft.nhs.uk01204 390390 ext. 3848

St Luke's Hospital - Bradford Teaching Hospitals NHS Foundation Trust

Bradford BD5 0NA, United Kingdom

Recruiting
Hospital R&D contact (matched)

Jane Dennison

bradfordresearch.applications@bthft.nhs.uk01274 382575

Royal Sussex County Hospital - University Hospitals Sussex NHS Foundation Trust

Brighton BN2 5BE, United Kingdom

Recruiting
Hospital R&D contact (matched)

Scott Harfield

uhsussex.research@nhs.net01273 696955 ext. 67497

Southmead Hospital - North Bristol NHS Trust

Bristol BS10 5NB, United Kingdom

Recruiting
Hospital R&D contact (matched)

Helen Lewis-White

Research@nbt.nhs.uk0117 41 49330

Burnley General Hospital- East Lancashire Hospitals NHS Trust

Burnley BB10 2PQ, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research and Development

research@elht.nhs.uk01254 732756

Addenbrooke's Hospital - Cambridge University Hospitals NHS Foundation Trust

Cambridge CB2 0QQ, United Kingdom

Recruiting
Hospital R&D contact (matched)

Stephen Kelleher

cuh.research@nhs.net01223 348490

Cheltenham General Hospital - Gloucestershire General Hospitals NHS Foundation Trust

Cheltenham GL53 7AN, United Kingdom

Recruiting
Hospital R&D contact (matched)

R&I Professional Services

ghn-tr.glos.riprofessionalservices@nhs.net033 422 5467

Countess of Chester Hospital - Countess of Chester Hospital NHS Trust

Chester CH2 1HJ, United Kingdom

Recruiting
Hospital R&D contact (matched)

Jude Prince

coch.rd-facilitator@nhs.net01244 365243

Leighton Hospital - Mid Cheshire NHS Foundation Trust

Crewe CW1 4QJ, United Kingdom

Recruiting
Hospital R&D contact (matched)

Charis Emmett

charis.emmett@mcht.nhs.uk01270 278095

Darlington Memorial Hospital - County Durham and Darlington NHS Foundation Trust

Darlington DL3 6HX, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research and Development Team cdda-tr.Research@nhs.net

nencadmin@nihr.ac.uk01325 743366

Royal Derby Hospital- University Hospitals of Derby and Burton NHS Foundation Trust

Derby DE22 3NE, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr Teresa Grieve

uhdb.researchgov@nhs.net01332 724639 / 01332 724638

Doncaster Royal Infirmary - Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust

Doncaster DN2 5LT, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr Jane Fearnside - Head of Research

dbth.clinicalresearch@nhs.net01302 644069

Russell's Hall Hospital - The Dudley Group NHS Foundation Trust

Dudley DY1 2HQ, United Kingdom

Recruiting
Hospital R&D contact (matched)

Claire Phillips

dgft.research.rhh@nhs.net01384 456111

Dumfries and Galloway Royal Infirmary - NHS Dumfries and Galloway

Dumfries DG2 8RX, United Kingdom

Recruiting
Hospital R&D contact (matched)

Colleen Bowthorpe

colleen.bowthorpe@nhs.scot01387 241815

Queen Margert Hospital - NHS Fife

Dunfermline KY12 0SU, United Kingdom

ACTIVE_NOT_RECRUITING
Hospital R&D contact (matched)

Frances Quirk

fife.fiferesearchapprovals@nhs.scot01383 623623 x 20955

University Hospital Hairmyres - NHS Lanarkshire

East Kilbride G75 8RG, United Kingdom

Recruiting

Western General Hospital -NHS Lothian

Edinburgh EH4 2XU, United Kingdom

Recruiting

Royal Devon & Exeter Hospital - Royal Devon and Exeter NHS Foundation Trust

Exeter EX2 5DW, United Kingdom

Recruiting
Hospital R&D contact (matched)

Samantha Smart

rduh.research-eastern@nhs.net01392 406075

Queen Elizabeth Hospital - Gateshead Health NHS Foundation Trust

Gateshead NE9 6SX, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research and Development Team ghnt.researchanddevelopment@nhs.net

ghnt.researchanddevelopment@nhs.net0191 4820000

Beatson West of Scotland Cancer Centre - Greater Glasgow Health Board

Glasgow G12 0YN, United Kingdom

Recruiting
Hospital R&D contact (matched)

Jennifer McLean

jennifer.mclean@health.scot.nhs.uk0131 537 4718

Royal Surrey County Hospital - Royal Surrey NHS Foundation Trust

Guildford GU2 7XX, United Kingdom

Recruiting
Hospital R&D contact (matched)

Stephen Barnett

rsc-tr.ResearchAndDevelopment@nhs.net01483 688600

Harrogate District Hospital - Harrogate and District NHS Foundation Trust

Harrogate HG2 7SX, United Kingdom

Recruiting
Hospital R&D contact (matched)

Michelle Platton

hdft.research@nhs.net01423 555692

Hereford County Hospital- Wye Valley NHS Trust

Hereford HR1 2ER, United Kingdom

Recruiting
Hospital R&D contact (matched)

Kym Teale, Research Manager

clinical.trials@wvt.nhs.uk01432 355444 Ext 5279

Wycombe Hospital - Buckinghamshire Healthcare NHS Trust

High Wycombe HP11 2TT, United Kingdom

Recruiting
Hospital R&D contact (matched)

Nicola Bowers (Head of Research)

nicolabowers@nhs.net07956645035

Huddersfield Royal Infirmary- Calderdale and Huddersfield NHS Foundation Trust

Huddersfield HD3 3EA, United Kingdom

Recruiting
Hospital R&D contact (matched)

Tracy Wood/Lesley Thomis

R&D@cht.nhs.uk01484 343396

Castle Hill Hospital - Hull University Teaching Hospitals NHS Trust

Hull HU16 5JQ, United Kingdom

Recruiting
Hospital R&D contact (matched)

James Illingworth

hyp-tr.development.research@nhs.net01482 461883 or 461903

Ipswich Hospital - East Suffolk and North Essex NHS Foundation Trust

Ipswich IP4 5PD, United Kingdom

Recruiting
Hospital R&D contact (matched)

Frances Farnworth

R&D@esneft.nhs.uk01473 704787

West Middlesex University Hospital - Chelsea and Westminster Hospital NHS Foundation Trust

Isleworth TW7 6AF, United Kingdom

Recruiting
Hospital R&D contact (matched)

Damon Foster

damon.foster2@nhs.net020 3316 6887

Royal Lancaster Infirmary - University Hospitals of Morecambe Bay NHS Foundation Trust

Lancaster LA1 4RP, United Kingdom

Recruiting
Hospital R&D contact (matched)

Nichola Verstraelen

Research.Development@mbht.nhs.uk01524 516484

Forth Valley Royal Hospital - NHS Forth Valley

Larbert FK5 4WR, United Kingdom

Recruiting
Hospital R&D contact (matched)

Emma McDonough

fv.randd-depart@nhs.scot---

St James's University Hospital - Leeds Teaching Hospitals NHS Trust

Leeds LS9 7TF, United Kingdom

Recruiting
Hospital R&D contact (matched)

R&I Team

leedsth-tr.researchfacilitation@nhs.net0113 2060469

Glenfield Hospital - University Hospitals of Leicester NHS Trust

Leicester LE3 9QP, United Kingdom

Recruiting
Hospital R&D contact (matched)

Carolyn Maloney

uhl-tr.researchandinnovationadminmailbox@nhs.net0116 258 8351

Lincoln County Hospital - United Lincolnshire Hospitals NHS Trust

Lincoln LN2 5QY, United Kingdom

ACTIVE_NOT_RECRUITING
Hospital R&D contact (matched)

Ms Hannah Finch

hannah.finch9@nhs.net01522 573941 ext 582059-

Prince Phillip Hospital -Hywel Dda University Health Board

Llanelli SA14 8QF, United Kingdom

Recruiting
Hospital R&D contact (matched)

Chris Tattersall

Hdd.Research-Development@wales.nhs.uk01437 773813

North Middlesex University Hospital - North Middlesex University Hospital NHS Trust

London N18 1QX, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr Deborah McCartney

deborah.mccartney2@nhs.net+44(0)208 887 2307

The Whittington Hospital - Whittington Health NHS Trust

London N19 5NF, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research Support Team

whh-tr.researchsupport@nhs.net0207 288 3585

UCL Hospital - University College London Hospitals NHS Foundation Trust

London NW1 2BU, United Kingdom

ACTIVE_NOT_RECRUITING
Hospital R&D contact (matched)

Rajinder Sidhu - Associate Director, Research Governance and Operations

uclh.jro-communications@nhs.net020 3447 9825

Royal Free Hospital - Royal Free London NHS Foundation Trust

London NW3 2QG, United Kingdom

Recruiting
Hospital R&D contact (matched)

Natasha Ajraam

rf-tr.randd@nhs.net020 375 82150

Kings College Hospital - King's College Hospital NHS Foundation Trust

London SE5 9RS, United Kingdom

Recruiting
Hospital R&D contact (matched)

Jasmine Palmer

kch-tr.research@nhs.net0203 299 1980

The Royal Marsden NHS Foundation Trust

London SM2 5PT, United Kingdom

Recruiting
Hospital R&D contact (matched)

Mark Brandon-Grove

research.development@rmh.nhs.uk020 3186 5416

Charing Cross Hospital -Imperial College Healthcare NHS Trust

London W6 8RF, United Kingdom

Recruiting
Hospital R&D contact (matched)

Donna Copeland

donna.copeland@nhs.net---

Luton and Dunstable Hospital -Bedfordshire Hospitals NHS Foundation Trust

Luton LU4 0DZ, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr. Mohammad Wasil. Assistant Director of RD&I

research.bedford@bedsft.nhs.ukContact:

Wythenshawe Hospital - Manchester University Hospital NHS Foundation Trust

Manchester M23 9LT, United Kingdom

Recruiting
Hospital R&D contact (matched)

Elizabeth Mainwaring

R&D.applications@mft.nhs.uk0161 276 3340

North Manchester General -Manchester University NHS Foundation Trust

Manchester M8 5RB, United Kingdom

Recruiting
Hospital R&D contact (matched)

Elizabeth Mainwaring

R&D.applications@mft.nhs.uk0161 276 3340

Borders General Hospital -NHS Borders

Melrose TD6 9BS, United Kingdom

Recruiting
Hospital R&D contact (matched)

Olga Balazikova

research@sabp.nhs.uk01372 216 584

Clatterbridge Cancer Centre - The Clatterbridge Cancer Centre NHS Foundation Trust

Metropolitan Borough of Wirral CH63 4JY, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr Maria Maguire

maria.maguire2@nhs.net0151 556 5321

Clatterbridge Hospital - Wirral University Teaching Hospital NHS Foundation Trust

Metropolitan Borough of Wirral CH63 4JY, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr Carol Kingdon

wih-tr.ResearchDepartment@nhs.net0151 604 7315

The James Cook University Hospital - South Tees Hospitals NHS Foundation Trust

Middlesbrough TS4 3BW, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research and Development

stees.dtvra@nhs.net01642 854089

Milton Keynes Hospital - Milton Keynes University Hospital NHS Trust

Milton Keynes MK6 5LD, United Kingdom

Recruiting
Hospital R&D contact (matched)

Antoanela Colda

Antoanela.colda@mkuh.nhs.uk01908 995119 / 01908 996651

Royal Victoria Infirmary- Newcastle Upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne NE1 4LP, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research and Development

nuth.genericqueries@nhs.net0191 282 4926

North Tyneside General Hospital - Northumbria Healthcare NHS Foundation Trust

North Shields NE29 8NH, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research and Development

researchanddevelopment@nhct.nhs.uk0191 2934087

Churchill Hospital - Oxford University Hospitals NHS Foundation Trust

Oxford OX3 7LE, United Kingdom

Recruiting
Hospital R&D contact (matched)

Shahista Hussain

ouhtma@ouh.nhs.uk---

Royal Alexandra Hospital - NHS Greater Glasgow and Clyde

Paisley PA2 9PN, United Kingdom

Recruiting
Hospital R&D contact (matched)

Radek Penar

radoslaw.penar@nhs.scotn/a

Derriford Hospital - University Hospitals Plymouth NHS Trust

Plymouth PL6 8DH, United Kingdom

Recruiting
Hospital R&D contact (matched)

R&D Manager

plh-tr.RD-office@nhs.net01752 431776

Queen Alexandra Hospital - Portsmouth Hospitals University NHS Trust

Portsmouth PO6 3LY, United Kingdom

Recruiting
Hospital R&D contact (matched)

Joe Shoebridge

research.office@porthosp.nhs.uk023 9228 6236

St Helen's Hospital - St Helens and Knowsley Teaching Hospitals NHS Trust

Prescot L35 5DR, United Kingdom

Recruiting

Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust

Preston PR2 9HT, United Kingdom

Recruiting
Hospital R&D contact (matched)

Paul Brown

Research.Access@lthtr.nhs.uk01772 522031

East Surrey Hospital - Surrey & Sussex Healthcare NHS Trust

Redhill RH1 5RH, United Kingdom

Recruiting
Hospital R&D contact (matched)

Scott Harfield

uhsussex.research@nhs.net01273 696955 ext. 67497

Rotherham General Hospital - The Rotherham NHS Foundation Trust

Rotherham S60 2UD, United Kingdom

Recruiting
Hospital R&D contact (matched)

Rachel Walker

rgh-tr.researchanddevelopment@nhs.net01709 426066

Weston Park Hospital - Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield S10 2SJ, United Kingdom

Recruiting
Hospital R&D contact (matched)

Alessia Dunn

STH.ResearchAdministration@nhs.net0114 2712550

St Alban's Hospital - West Hertfordshire Hospitals NHS Trust

St Albans AL3 5PN, United Kingdom

Recruiting
Hospital R&D contact (matched)

Fiona Smith

wherts-tr.RDapplications@nhs.net01923 217854

Lister Hospital - East and North Hertfordshire NHS Foundation Trust

Stevenage SG1 4AB, United Kingdom

Recruiting
Hospital R&D contact (matched)

Rishma Bhatti, Head of Research (Mount Vernon Cancer Centre)

mvccresearch.enh-tr@nhs.net0203 826 2068 / 2069

University Hospital North Tees - North Tees and Hartlepool NHS Foundation Trust

Stockton-on-Tees TS19 8PE, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research and Development

nth-tr.ntandh.researchdevelopment@nhs.net01642 624090

Royal Stoke University Hospital - University Hospitals of North Midlands NHS Trust

Stoke-on-Trent ST4 6QG, United Kingdom

Recruiting
Hospital R&D contact (matched)

Sarah Jones

studysetup@uhnm.nhs.uk01782 675385

Singleton hospital - Swansea Bay University Health Board

Swansea SA2 8QA, United Kingdom

Recruiting
Hospital R&D contact (matched)

Jemma Rogers

Jemma.Rogers@wales.nhs.uk01792 530890

Musgrove park Hospital -Somerset NHS Foundation Trust

Taunton TA1 5DA, United Kingdom

Recruiting
Hospital R&D contact (matched)

Karen Tanner

Research@somersetft.nhs.uk01935 384559

Croydon University Hospital - Croydon Health Services NHS Trust

Thornton Heath CR7 7YE, United Kingdom

Recruiting
Hospital R&D contact (matched)

Non Portfolio - Michael Chang Portfolio - South West Cluster Office

ch-tr.research@nhs.net0208 401 3610

Royal Cornwall Hospital - Royal Cornwall Hospitals NHS Trust

Truro TR1 3LJ, United Kingdom

Recruiting
Hospital R&D contact (matched)

Abi Weeks

rch-tr.CornwallResearch@nhs.net01872 25 6424

Hillingdon Hospital - The Hillingdon Hospitals NHS Foundation Trust

Uxbridge UB8 3NN, United Kingdom

Recruiting
Hospital R&D contact (matched)

Geraldine Landers

thh.research.hillingdon@nhs.net01895 279021/ Ext 3021

Pinderfields Hospital - Mid Yorkshire Hospitals NHS Trust

Wakefield WF1 4DG, United Kingdom

Recruiting
Hospital R&D contact (matched)

Judith Holliday

Midyorks.My.Research@nhs.net01924 543772

Southend Hospital and Broomfield Hospital -Mid and South Essex NHS Foundation Trust

Westcliff-on-Sea SS0 0RY, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr Sam Hayton

mse.researchenquiries@nhs.net---

Royal Albert Edward Infirmary - Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust

Wigan WN1 2NN, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research Governance Office

ResearchAdmin@wwl.nhs.uk0300 707 6465

King Edward VII Hospital - Frimley Health NHS Foundation Trust

Windsor SL4 3DP, United Kingdom

Recruiting

New Cross Hospital - The Royal Wolverhampton NHS Trust

Wolverhampton WV10 0QP, United Kingdom

Recruiting
Hospital R&D contact (matched)

Sarah Glover

rwh-tr.rdpmteam@nhs.net01902 695065

Worcestershire Royal Hospital - Worcestershire Acute Hospitals NHS Trust

Worcester WR5 1JR, United Kingdom

Recruiting
Hospital R&D contact (matched)

Hannah Wood, Research Manager

wah-tr.researchandinnovation@nhs.net---

Yeovil District Hospital -Yeovil District Hospital NHS Trust

Yeovil BA21 4AT, United Kingdom

Recruiting

York Hospital - York and Scarborough Teaching Hospitals NHS Foundation Trust

York YO31 8HE, United Kingdom

Recruiting
Hospital R&D contact (matched)

Lydia Harris

yhs-tr.research.governance@nhs.net01904 726606

How to Get in Touch

Amit Goyal, MS, MD, FRCS

Sponsor contact

CONTACT

+44 1332785538 amit.goyal@nhs.net
Data sourced from ClinicalTrials.gov · Last verified: 2026-03