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Capturing MultiORgan Effects of COVID-19

View on ClinicalTrials.gov ↗

At a glance

What the study gets you: Health checks and monitoring — no treatment given
Type of study: Observational (no treatment given)
Time in hospital: In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention: Magnetic Resonance Imaging (diagnostic test)
How long the study runs: Study runs about 72 months (dates as stated)
About the drug or intervention: Magnetic Resonance Imaging — diagnostic test: We will undertake multi-organ MRI to assess the health of vital organs including the brain, heart, lung, kidneys and liver.
Patient visit burden: Not specified by the sponsor

Type of study: Observing health over time
Ages: 18 Years to 100 Years
Who: All
Number of participants: 750
Started: 2020-05-13
Last checked: 2025-01

Plain English Summary

What is this study?

• Testing a new treatment for coronavirus infection
• Clinical study - 750 participants
• The C-MORE study is prospective observational holistic longitudinal study which will characterise the prevalence of multi-organ injury among COVID-19 survivors post hospital discharge and assess its effects on quality of life, exercise tolerance and mental health

Who can take part?

• Ages 18 Years to 100 Years
• Diagnosed with coronavirus infection

Where?

• Oxford - University of Oxford

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The C-MORE study is prospective observational holistic longitudinal study which will characterise the prevalence of multi-organ injury among COVID-19 survivors post hospital discharge and assess its effects on quality of life, exercise tolerance and mental health.

More detail

Since the outbreak of Coronavirus disease (COVID-19), hundreds of thousands of lives have been lost and millions significantly affected. Although primarily a respiratory viral illness, emerging data suggests that multiorgan involvement is common in those with moderate-severe infections. Whether or not persistent multiorgan damage will be seen in COVID-19 survivors is unknown. C-MORE is an observational study that aims to investigate the long-term effects of COVID-19 on the lungs, heart, brain, liver and kidneys using advanced state-of-the art magnetic resonance imaging (MRI) technology. The study will assess 616 patients with laboratory-confirmed COVID-19 from leading UK centres and undertake multi-organ magnetic resonance imaging at 3, 6, and 12 months following the onset of COVID-19 symptoms. In addition, assessments of breathing, exercise capacity, cognition and mental health will be carried out. The study will describe the prevalence of persistent multi-organ injury in COVID-19 patients and assess how this relates to comorbid conditions, severity of acute respiratory illness, immunological response, genetic factors, quality of life and mental health.

Coronavirus InfectionMulti-Organ Disorder

How this trial compares with your answers

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What we know so far

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

Age: 18 Years - 100 Years
Who can join: All genders

Biomarkers mentioned

eGFR

What the study is looking for

✓Participant is willing and able to give agreement to take part for participation in the study.
✓Male or Female, aged 18 years or above.
✓Diagnosis of COVID-19 infection confirmed by detection of viral nucleic acid on reverse-transcription Polymerase...
✓Controls: Participants with no serological evidence of previous infection, or active/previous symptoms suggestive of...

Who cannot take part

✗safety concern to MRI e.g. pregnancy, pacemaker, ferromagnetic implant, shrapnel injury, severe claustrophobia,...
✗Any other significant disease or disorder which, in the opinion of the investigator, might influence the...
✗Any signs of active COVID-19 infection on day of visit.
✗Significantly impaired kidney function (eGFR\<30 ml/min)

See the full criteria

Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 years or above. * Diagnosis of COVID-19 infection confirmed by detection of viral nucleic acid on reverse-transcription Polymerase Chain Reaction (RT-PCR). * Infection should be of moderate to severe intensity (i.e, patients with clinical signs of pneumonia such as respiratory rate \> 30 breaths/min; or severe respiratory distress; or SpO2 \< 90% (on room air) and admission for \>48 hours. * Controls: Participants with no serological evidence of previous infection, or active/previous symptoms suggestive of COVID-19, and who may or may not have comorbidities. Exclusion Criteria: * Contraindication to MRI e.g. pregnancy, pacemaker, ferromagnetic implant, shrapnel injury, severe claustrophobia, inability to lie flat. * Any other significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study. * Any signs of active COVID-19 infection on day of visit. * Significantly impaired renal function (eGFR\<30 ml/min)

Where Is This Study? (1 UK site)

University of Oxford

Oxford OX3 9DU, United Kingdom

Recruiting

Site contact (verified)

Stefan Neubauer, MD, FMedSCiPrincipal Investigator

Betty Raman, MBBS, FRACP, DPhil0186534580 betty.raman@cardiov.ox.ac.uk

Mark Cassar, MBBS0186534580

How to Get in Touch

Betty Raman, MBBS, DPhil, FRACP

Sponsor contact

CONTACT

01865234580 betty.raman@cardiov.ox.ac.uk

Data sourced from ClinicalTrials.gov · Last verified: 2025-01