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Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy

View on ClinicalTrials.gov ↗

At a glance

What the study gets you: Access to the study treatment being tested
Type of study: Interventional (receives a drug or procedure)
Time in hospital: In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention: Blood collection for genetic analysis (genetic)
How long the study runs: Study runs about 117 months (dates as stated)
About the drug or intervention: Blood collection for genetic analysis — genetic: Blood collection for genetic analysis
Patient visit burden: Not specified by the sponsor

Type of study: Testing a treatment
Ages: Not specified
Who: All
Number of participants: 700
Started: 2019-03-12
Last checked: 2026-04

Plain English Summary

What is this study?

• Testing a new treatment for takotsubo cardiomyopathy
• NA - 700 participants
• Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences

Who can take part?

• Adults
• Diagnosed with takotsubo cardiomyopathy

Where?

• Aberdeen - Cardiac Research Office, Aberdeen Royal Infirmary
• Aberdeen - Cardiovascular Research Facility

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. In the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. This could also have implications for their families.

More detail

Acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. Despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. The researchers propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. The investigators will also archive DNA for identification of future candidate genetic variants. Ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward.

Takotsubo Cardiomyopathy

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What we know so far

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Still need:

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

Age: Not specified
Who can join: All genders

What the study is looking for

✓All patients who have been diagnosed with Takotsubo cardiomyopathy in Scotland between 2010 to date.
✓Familial cases elsewhere in the world who would be willing to participate.

Who cannot take part

✗Unwillingness to participate

See the full criteria

Inclusion Criteria: * All patients who have been diagnosed with Takotsubo cardiomyopathy in Scotland between 2010 to date. * Familial cases elsewhere in the world who would be willing to participate. Exclusion Criteria: * Unwillingness to participate