At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Assessment of 24 hour blood pressure and arterial stiffness (diagnostic test)
- How long the study runs
- Study runs about 81 months (dates as stated)
- About the drug or intervention
- Assessment of 24 hour blood pressure and arterial stiffness — diagnostic test: Assessment of 24 hour blood pressure and arterial stiffness using Mobil-o-graph device
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Observing health over time
- Ages
- 18 Years to 90 Years
- Who
- All
- Number of participants
- 120
- Started
- 2020-03-17
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for cardiovascular risk factor
- • Clinical study - 120 participants
- • In health, blood pressure (BP) falls at night by \>10% compared with day-time values
Who can take part?
- • Ages 18 Years to 90 Years
- • Diagnosed with cardiovascular risk factor
Where?
- • Edinburgh - Royal Infirmary of Edinburgh
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
In health, blood pressure (BP) falls at night by \>10% compared with day-time values. This natural dipping pattern is important as without it there is an increased risk of cardiovascular disease (CVD). Recent evidence suggests that chronotherapy (taking anti-hypertensive medication at bedtime instead of in the morning) may enhance nocturnal BP dipping and reduce the risk of CVD events. There is therefore an urgent need to characterise diurnal BP patterns in patients who may be at risk of reduced nocturnal dipping in order to maximise protective therapy in all those who would benefit. Similarly, it has previously been demonstrated that increased arterial stiffness is associated with increased CVD risk, however little is known about whether loss of diurnal variations in arterial stiffness confer addition risk. Kidney disease is independently associated with increased CVD events, but the exact makeup of this risk is not clear. Within this heterogenous cohort several very distinct groups exist including those with acute kidney injury (AKI), chronic kidney disease (CKD), inflammatory conditions like small vessel vasculitis (SVV), and those who have either donated or received a kidney transplant. Diurnal BP and arterial stiffness patterns within these patient groups are not well characterised. The investigators will recruit patients at increased risk of CVD from the Royal Infirmary of Edinburgh Renal and Vasculitis Clinics. Participants will undergo 24-hour ambulatory BP and arterial stiffness measurement in conjunction with day- and night-time blood and urine sampling on two separate occasions. This study aims to characterise diurnal patterns of BP and arterial stiffness in patients at increased risk of CVD and compare findings with healthy controls. In doing so, the investigators aim to allow more targeted CVD risk reduction strategies and improve long-term patient outcomes.
How this trial compares with your answers
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What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years - 90 Years
- Who can join: All genders
What the study is looking for
- ✓CKD as defined by the Kidney Disease Outcome Quality Initiative (K/DOQI) classification
- ✓AKI as defined by the Kidney Disease Improving Global Outcomes (KDIGO) classification
- ✓Small vessel vasculitis
- ✓Kidney transplant recipient
- ✓Kidney donor We will also recruit a healthy control group from the community.
Who cannot take part
- ✗Age \<18 years and \>90 years
- ✗Lack of ability to provide agreement to take part
See the full criteria
Where Is This Study? (1 UK site)
Royal Infirmary of Edinburgh
Edinburgh EH164SA, United Kingdom
How to Get in Touch
Neeraj Dhaun, MBChB PhD
Sponsor contactCONTACT