At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Full-mouth periodontal examination using computerised Florida probe (other)
- How long the study runs
- Study runs about 109 months (dates as stated)
- About the drug or intervention
- Full-mouth periodontal examination using computerised Florida probe — other: It is an observational study to investigate the prevalence of periodontitis in cases and controls.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Observing health over time
- Ages
- 20 Years to 90 Years
- Who
- All
- Number of participants
- 320
- Started
- 2018-02-16
- Last checked
- 2026-05
Plain English Summary
What is this study?
- • Testing a new treatment for myocardial infarction, acute
- • Clinical study - 320 participants
- • Heart attack remains a major cause of death in adult population worldwide and especially within Scotland
Who can take part?
- • Ages 20 Years to 90 Years
- • Diagnosed with myocardial infarction, acute
Where?
- • Aberdeen - Dr Karolin Hijazi
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Heart attack remains a major cause of death in adult population worldwide and especially within Scotland. A large portion of the general population has an increased risk of suffering from a heart attack because of their genetic make-up, disease profile and lifestyle choices. Literature suggests that apart from these known risk factors, long-standing inflammation (reaction of tissues to infection or injury) elsewhere in the body may be responsible for heart attacks. It has been suggested that gum disease may be one such condition. If left untreated, gum disease may expose the entire body to a long-term inflammatory burden where inflammatory molecules can disseminate from the gums into the bloodstream and affect various body structures. This study explores the influence of gum disease on the risk of heart attack by comparing the gum health of participants who recently had a heart attack to the gum health of participants with no history of heart problems after accounting for other risk factors. Findings will provide critical information for the design of our forthcoming study to establish the effect of treatment of gum disease on the risk of heart attack, and its cost-effectiveness. Ultimately this research will tackle another risk factor for heart attacks and thus inform enhancement of public health prevention strategies.
More detail
Coronary artery disease (CAD) is a multifactorial condition leading to most cases of myocardial infarction and results from interaction of genetic, lifestyle and environmental factors. However, as many as 50% of CAD patients lack classical risk factors of CAD suggesting the presence of other contributory mechanisms. Inflammation plays a central role in the initiation and growth of the plaques which form in the arteries (atherosclerosis) and lead to CAD3. As such periodontal disease, an inflammatory process leading to progressive destruction of tooth-supporting structures, has been associated with CAD. In vivo pre-clinical studies have shown that bacteria associated with periodontal disease can exacerbate atherosclerosis 7. Numerous clinical studies have explored the association between periodontal disease and CAD at different follow-up times following episodes of myocardial infarction 8-9. However, there are no reports investigating this association during the acute phase of myocardial infarction. In addition the need for rigorous matching of all known CAD risk factors in case control studies has so far been overseen. RATIONALE FOR STUDY: This case-control study aims to compare the health of tooth supporting structures (periodontium) in patients hospitalised for acute myocardial infarction to a control group of patients rigorously matched for known CAD risk factors, age and gender.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 20 Years - 90 Years
- Who can join: All genders
What the study is looking for
- ✓cases: Patients aged 20-90 admitted with acute myocardial infarction
See the full criteria
Where Is This Study? (1 UK site)
Dr Karolin Hijazi
Aberdeen AB25 2ZR, United Kingdom