At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Not specified by the sponsor
- How long the study runs
- Study runs about 167 months (dates as stated)
- About the drug or intervention
- Not specified by the sponsor
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Observing health over time
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 394
- Started
- 2014-01-31
- Last checked
- 2026-07
Plain English Summary
What is this study?
- • Testing a new treatment for bariatric surgery candidate
- • Clinical study - 394 participants
- • Our primary aim is to investigate the prevalence and severity of Periodonotal Disease (PD) in a population of obese patients
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with bariatric surgery candidate
Where?
- • London - Barts Health NHS Trust Dental Hospital
- • London - Centre for Oral Clinical Research (COCR)
- • London - St Bartholomew's Hospital, Barts Health NHS Trust
- • Luton - Luton and Dunstable University Hospital
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Our primary aim is to investigate the prevalence and severity of Periodonotal Disease (PD) in a population of obese patients. Our secondary objectives are to: Investigate inflammatory biomarkers that have been associated with PD in the saliva of obese patients. Investigate the association of FTO gene (Obesity) polymorphisms with the prevalence of PD in this population. Investigate and describe the subgingival microbial flora in obese patients with PD from subgingival dental plaque samples as well as the salivary samples.
More detail
Overall design and plan of the study This is a cross-sectional association study. The study population will be recruited among individuals attending the UCLH Centre for Weight Loss, Metabolic \& Endocrine Surgery (UCLH bariatric clinic) and have given written informed consent to the study. Experimental Design All individuals who consent to this study will receive as part of their routine care a medical examination, where a series of parameters are recorded (including age, gender, smoking status, Bio-impedance for full body composition, ethnicity, and body mass index). These data will be copied for this study. A blood sample will also be collected for genetic analysis unless the patients have DNA already collected and it has been verified that the results are available. In that case no venepuncture will be needed. All subjects will receive a basic periodontal examination (BPE). For individuals with signs of destructive periodontitis (BPE scores 3-4) full mouth plaque and gingival bleeding scores will also be calculated. In addition to that also a comprehensive full mouth periodontal probing depths assessment will be performed.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Treatment history
Treatments you must have had:
- ✓ a BMI of higher or equal to 30 kg/ m2
- ✓ voluntarily given written informed consent
What the study is looking for
- ✓Each subject must meet all of the following inclusion criteria to be enrolled in the study:
- ✓Subject must be over 18 years of age.
- ✓Subject must have a BMI of higher or equal to 30 kg/ m2
- ✓Subject must have voluntarily given written agreement to take part.
Who cannot take part
- ✗Subjects meeting any of the following exclusion criteria are not to be enrolled in the study:
- ✗Subject is currently involved in other research involving the use of antibiotics or novel or unknown medications.
- ✗Self-reported pregnancy.
- ✗Subject is on chronic treatment (i.e., two weeks or more) with specific medications known to affect periodontal...
- ✗Subject knowingly has HIV or Viral Hepatitis.
See the full criteria
Where Is This Study? (4 UK sites)
Barts Health NHS Trust Dental Hospital
London E1 1BB, United Kingdom
Centre for Oral Clinical Research (COCR)
London E1 2AD, United Kingdom
St Bartholomew's Hospital, Barts Health NHS Trust
London, United Kingdom
Luton and Dunstable University Hospital
Luton, United Kingdom
Dr. Mohammad Wasil. Assistant Director of RD&I
research.bedford@bedsft.nhs.ukContact:How to Get in Touch
Vandana Luthra, Dr.
Sponsor contactCONTACT