At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Cyclophosphamide (drug), Fludarabine (drug), KITE-363 (biological), KITE-753 (biological)
- How long the study runs
- Study runs about 100 months (dates as stated)
- About the drug or intervention
- Cyclophosphamide — drug: Lymphodepleting chemotherapy administered intravenously · Fludarabine — drug: Lymphodepleting chemotherapy administered intravenously · KITE-363 — biological: A single infusion of CAR-transduced autologous T cells administered intravenously · KITE-753 — biological: A single infusion of CAR-transduced autologous T cells administered intravenously
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 247
- Started
- 2021-10-27
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for relapsed and/or refractory b-cell lymphoma
- • Phase1/Phase2 - 247 participants
- • The goal of this clinical study is to learn more about the safety and effectiveness of the study drugs, KITE-363 and KITE-753, in participants with relapsed and/or refractory B-cell lymphoma
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with relapsed and/or refractory b-cell lymphoma
Where?
- • London - King's College Hospital
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The goal of this clinical study is to learn more about the safety and effectiveness of the study drugs, KITE-363 and KITE-753, in participants with relapsed and/or refractory B-cell lymphoma.
More detail
Eligible study participants who have received IP administration with either KITE-363 or KITE-753 will transition to a separate Long-term Follow-up study (Study KT-US-982-5968) to complete the remainder of the 15-year follow-up assessments.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓for Phase 1a/b and Phase 2
- ✓Relapsed and/or refractory B-cell lymphoma (R/R BCL).
- ✓At least 1 measurable lesion.
- ✓Adequate organ and bone marrow (BM) function.
Who cannot take part
- ✗for Phase 1a/b and Phase 2
- ✗\- History of chimeric antigen receptor (CAR) therapy or other genetically modified T cell therapy.
- ✗History of allogeneic stem cell transplant (allo-SCT).
- ✗Auto-SCT within 6 weeks before the planned KITE-363 or KITE-753 infusion.
- ✗Presence of fungal, bacterial, viral, or other infection that is uncontrolled or requires intravenous (IV)...
See the full criteria
Where Is This Study? (1 UK site)
King's College Hospital
London SE5 9RS, United Kingdom
How to Get in Touch
Medical Information
Sponsor contactCONTACT
