How do I find clinical trials in the UK?

Use TrialConnect to search by condition, location, or eligibility. We index over 29,000 UK clinical trials from ClinicalTrials.gov, updated daily. Enter your condition and we show matching trials near you.

Are there paid clinical trials in the UK?

Yes. Healthy volunteers can earn £500–£3,000 for Phase 1 and bioequivalence studies. TrialConnect lists paid research studies at UK research units in London, Leeds, Nottingham, and more.

What conditions have clinical trials available?

TrialConnect covers 41 conditions including breast cancer, lung cancer, diabetes, heart failure, COPD, multiple sclerosis, Parkinson's disease, Crohn's disease, and many more.

Is TrialConnect free?

Yes. TrialConnect is completely free for patients. We are not affiliated with the NHS or NIHR. Data is sourced from ClinicalTrials.gov.

Am I eligible for a clinical trial?

Each trial has specific eligibility criteria including age, condition, medical history, and current treatments. TrialConnect shows you trials that may match your situation, but only the trial team can confirm eligibility.

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis

View on ClinicalTrials.gov ↗

At a glance

What the study gets you: Access to the study treatment being tested
Type of study: Interventional (receives a drug or procedure)
Time in hospital: Mix of remote tasks and in-person visits
Drug or intervention: Volixibat (drug), Placebo (drug)
How long the study runs: Study runs about 87 months (dates as stated)
About the drug or intervention: Volixibat — drug: Oral capsules, administered twice daily. · Placebo — drug: Capsules matched to study drug without the active pharmaceutical ingredient
Patient visit burden: Not specified by the sponsor

Type of study: Testing a treatment
Ages: 18 Years and over
Who: All
Number of participants: 333
Started: 2021-09-22
Last checked: 2026-08

Plain English Summary

What is this study?

• Testing a new treatment for primary biliary cholangitis
• Phase2 - 333 participants
• The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with Primary Biliary Cholangitis (PBC), and to assess the possible impact on the disease progression of PBC

Who can take part?

• Ages 18 Years and over
• Diagnosed with primary biliary cholangitis

Where?

• Southampton - University Hospital Southampton NHS Foundation Trust
• Birmingham - University Hospitals Birmingham NHS Foundation Trust of Trust Headquarters
• Belfast - Belfast Health & Social Care Trust (BHSCT) Royal Victoria Hospital
• London - Royal Free Hospital NHS Foundation Trust
• +3 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with Primary Biliary Cholangitis (PBC), and to assess the possible impact on the disease progression of PBC.

Primary Biliary CholangitisPBC

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search

Age· Tell us your age for better matching

Gender· Tell us your sex for better matching

Still need:

• Tell us your age for better matching
• Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

Age: 18 Years and over
Who can join: All genders

What the study is looking for

✓Provide signed agreement to take part at the screening visit as well as comply with all study visits and requirements...
✓Male or female, age ≥18 years at the screening visit
✓Confirmed diagnosis of PBC in line with the AASLD guidelines
✓UDCA, anti-pruritic medication and PPAR agonist use will be allowed if meeting additional criteria
✓Qualified pruritus associated with PBC as assessed by Adult ItchRO

Who cannot take part

✗Pruritus associated with an etiology other than PBC
✗Evidence or clinical suspicion of decompensated cirrhosis or a history of decompensation events
✗Current causing symptoms cholelithiasis or inflammatory gallbladder disease
✗History of small bowel surgery/resection impacting the terminal ileum that may disrupt the enterohepatic circulation.
✗Evidence, history, or suspicion of other liver diseases; PBC patients with AIH are not excluded

See the full criteria

Inclusion Criteria: * Provide signed informed consent at the screening visit as well as comply with all study visits and requirements through the end of the study * Male or female, age ≥18 years at the screening visit * Confirmed diagnosis of PBC in line with the AASLD guidelines * UDCA, anti-pruritic medication and PPAR agonist use will be allowed if meeting additional criteria * Qualified pruritus associated with PBC as assessed by Adult ItchRO Exclusion Criteria: * Pruritus associated with an etiology other than PBC * Evidence or clinical suspicion of decompensated cirrhosis or a history of decompensation events * Current symptomatic cholelithiasis or inflammatory gallbladder disease * History of small bowel surgery/resection impacting the terminal ileum that may disrupt the enterohepatic circulation. * Evidence, history, or suspicion of other liver diseases; PBC patients with AIH are not excluded * History of Liver transplantation