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UK Imaging Diabetes Study Seeing Diabetes Clearly

Sponsor: Perspectum

NCT ID: NCT05057403

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Health checks and monitoring — no treatment given
Type of study
Observational (no treatment given)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
MRI (other)
How long the study runs
Study runs about 145 months (dates as stated)
About the drug or intervention
MRI — other: MRI is not part of Pathway for patient with type two diabetes.
Patient visit burden
Not specified by the sponsor
Type of study
Observing health over time
Ages
18 Years and over
Who
All
Number of participants
1,000
Started
2022-05-30
Last checked
2025-11

Plain English Summary

What is this study?

  • • Testing a new treatment for type2 diabetes
  • • Clinical study - 1,000 participants
  • • Prospective, observational cohort study to cross-sectionally assess the health of multiple organs, using multiparametric abdominal magnetic resonance imaging (MRI) scan, and understand if resulting MRI metrics can predict future clinical events over a period of 5 years, in adult patients with type 2 diabetes lacking history of cardiovascular disease

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with type2 diabetes

Where?

  • • Didcot - Woodlands Medical Centre
  • • Eynsham - Eynsham Medical Centre
  • • Farringdon - White Horse Medical Practice
  • • Witney - Windrush Medical Practice
  • • +8 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

Prospective, observational cohort study to cross-sectionally assess the health of multiple organs, using multiparametric abdominal magnetic resonance imaging (MRI) scan, and understand if resulting MRI metrics can predict future clinical events over a period of 5 years, in adult patients with type 2 diabetes lacking history of cardiovascular disease.

More detail

This will be a multi-site study adopting a prospective, observational cohort study design. There will be no intervention to the standard of care. Study participants will be enrolled in this study for a total of 5 years, with only 1 month of active participation. Participants will be required to attend a screening visit and 2 study visits. The screening visit will involve a medical review and receiving informed consent based on the participant information leaflet already communicated to the patient, pre-screening. The first study visit- baseline (visit 1) - will involve anthropometric measurements and taking a blood and urine sample in order to perform standard of care measurements for type 2 diabetes at baseline and relevant circulating biomarkers. The second study visit will involve having a multi-organ, multiparametric MRI scan. Both visits will be within 28 days of the screening visit and carried out at local study sites. MRI metrics of organ health, clinical outcome measurements, blood samples and urine samples will be collected to assess the natural history of diabetes disease progression. Participants will be asked to give consent for access to their medical records held at NHS England and, if available, at their local GP surgery or hospital. Medical records access will include Hospital admissions (Hospital Episode Statistics), and mortality data collected by the Office for National Statistics and provided by NHS England to meet the primary objective. This data will be collected at 1, 3 and 5 years after baseline assessment.

Type2 Diabetes

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What we know so far

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

What the study is looking for

  • ✓Male or female at least 18 years of age and diagnosed with type 2 diabetes, with or without diabetic retinopathy.
  • ✓Participant willing and able to give agreement to take part for participation in the study.

Who cannot take part

  • ✗In 12 months prior to consent, evidence of existing cardiovascular event defined as at least one of:
  • ✗myocardial infarction
  • ✗ischaemic stroke
  • ✗hospital admission/discharge for unstable angina
  • ✗heart surgery
See the full criteria
Inclusion Criteria: * Male or female at least 18 years of age and diagnosed with type 2 diabetes, with or without diabetic retinopathy. * Participant willing and able to give informed consent for participation in the study. Exclusion Criteria: In 12 months prior to consent, evidence of existing cardiovascular event defined as at least one of: * myocardial infarction * ischaemic stroke * hospital admission/discharge for unstable angina * heart surgery * unstable angina * transient ischemic attack * The participant may not enter the study if they have any contraindication to magnetic resonance imaging (standard MR exclusion criteria including pregnancy, extensive tattoos, pacemaker, shrapnel injury, severe claustrophobia). * Patients with known autoimmune hepatitis, viral hepatitis, Wilson's disease or known significant structural renal tract abnormality. * Patients with known alcohol dependency. * Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the participant's ability to participate in the study

Where Is This Study? (12 UK sites)

Woodlands Medical Centre

Didcot OX11 0BB, United Kingdom

Recruiting
Site contact (verified)

Eynsham Medical Centre

Eynsham OX29 4QB, United Kingdom

Recruiting
Site contact (verified)

White Horse Medical Practice

Farringdon SN7 7YU, United Kingdom

Recruiting
Site contact (verified)

Windrush Medical Practice

Witney OX26 6JS, United Kingdom

Recruiting
Site contact (verified)

The House Partnership

Redhill RH1 1EB, United Kingdom

Recruiting
Site contact (verified)

Swansea Bay University Health Board

Baglan SA12 7BR, United Kingdom

NOT_YET_RECRUITING
Site contact (verified)

University Hospitals of Liverpool Group

Liverpool L9 7AL, United Kingdom

Recruiting
Site contact (verified)

Moorfields Eye Hospital NHS Foundation Trust

London, United Kingdom

ENROLLING_BY_INVITATION
Hospital R&D contact (matched)

Research Portfolio Managers- Daniela Narvaez, Anika Kadchha, Abi Chandrakumar, Xin Liu

moorfields.resadmin@nhs.net0207 566 2036

The Manor Group

Oxford OX3 9BP, United Kingdom

Recruiting
Site contact (verified)

Hedena Health

Oxford OX3 9JA, United Kingdom

Recruiting
Site contact (verified)

St Bartholomew and Hollow Way Medical Practice

Oxford OX4 1XB, United Kingdom

Recruiting
Site contact (verified)

Oxford Community Diagnostic centre

Oxford OX42LL, United Kingdom

Recruiting
Site contact (verified)

How to Get in Touch

Soubera Rymall, MSc

Sponsor contact

CONTACT

00447919272482 soubera.rymell@perspectum.com
Data sourced from ClinicalTrials.gov · Last verified: 2025-11