At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Teclistamab (drug), Lenalidomide (drug)
- How long the study runs
- Study runs about 115 months (dates as stated)
- About the drug or intervention
- Teclistamab — drug: Teclistamab will be administered via a subcutaneous injection (SC) · Lenalidomide — drug: Lenalidomide will be administered orally
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 1,594
- Started
- 2022-09-08
- Last checked
- 2026-10
Plain English Summary
What is this study?
- • Testing a new treatment for multiple myeloma
- • Phase3 - 1,594 participants
- • This is a multicenter, randomized, open-label, Phase 3 study in participants with newly diagnosed multiple myeloma to evaluate the benefits of teclistamab in combination with lenalidomide and teclistamab alone versus lenalidomide alone as maintenance therapy after autologous stem cell transplant
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with multiple myeloma
Where?
- • London - Hammersmith Hospital - Imperial College NHS Healthcare Trust
- • London - University College London (UCL)
- • Sutton - The Royal Marsden Hospital
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This is a multicenter, randomized, open-label, Phase 3 study in participants with newly diagnosed multiple myeloma to evaluate the benefits of teclistamab in combination with lenalidomide and teclistamab alone versus lenalidomide alone as maintenance therapy after autologous stem cell transplant.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
What the study is looking for
- ✓Must have a new diagnosis of multiple myeloma according to IMWG criteria and have received induction +/- consolidation.
- ✓Must not be intolerant to the starting dose of lenalidomide.
- ✓Must not have received any maintenance therapy.
- ✓Have an ECOG performance status score of 0, 1, or 2 at screening and immediately prior to the start of...
- ✓Have clinical laboratory values within prespecified range.
Who cannot take part
- ✗Received any prior BCMA-directed therapy.
- ✗Any previous therapy with an immune cell redirecting agent or gene modified adoptive cell therapy (eg, chimeric...
- ✗Discontinued treatment due to any AE related to lenalidomide as determined by the investigator.
- ✗Progressed on multiple myeloma therapy at any time prior to screening.
- ✗Received a cumulative dose of corticosteroids equivalent to ≥140 mg of prednisone within the 14 days prior to first...
See the full criteria
Where Is This Study? (3 UK sites)
Hammersmith Hospital - Imperial College NHS Healthcare Trust
London, United Kingdom
University College London (UCL)
London, United Kingdom
Rajinder Sidhu - Associate Director, Research Governance and Operations
uclh.jro-communications@nhs.net020 3447 9825The Royal Marsden Hospital
Sutton, United Kingdom
How to Get in Touch
Christine Witty
Sponsor contactCONTACT
Sabrin Tahri
Sponsor contactCONTACT
