At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Not specified by the sponsor
- How long the study runs
- Study runs about 72 months (dates as stated)
- About the drug or intervention
- Not specified by the sponsor
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Observing health over time
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 200
- Started
- 2022-04-06
- Last checked
- 2025-09
Plain English Summary
What is this study?
- • Testing a new treatment for oncology
- • Clinical study - 200 participants
- • A prospective observational cohort study of patients undergoing CPI therapy in which translational research is the fundamental aspect of the study
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with oncology
Where?
- • Chelsea - Royal Marsden NHS Foundation Trust
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
A prospective observational cohort study of patients undergoing CPI therapy in which translational research is the fundamental aspect of the study.
More detail
The study aims to enroll and obtain samples of investigational interest from 200 patients over a 36-month recruitment period. Blood and/ or stool samples will be taken at baseline, in context of irAE development / during CPI treatment and during follow-up. Skin samples may also be taken upon development of organspeciifc irAEs. Further assessments at baseline or during the course of or following treatment will be conducted in accordance with standard institutional practice and will be clinically driven. Clinical data, samples and results from archival, current or prospective diagnostic or therapeutic procedures will be used for research purposes within EXACT. IrAE clinical monitoring will be conducted in accordance with standard institutional practice and will be clinically driven.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓Written agreement to take part
- ✓Age 18 years or older
- ✓Confirmed diagnosis of any form of solid cancer with a clinical indication and appropriate treatment plan to...
Who cannot take part
- ✗Medical or psychological condition that would preclude agreement to take part
- ✗Planned participation in a drug trial receiving investigational agents
- ✗Subjects who have previously commenced immune checkpoint inhibitor therapy prior to study entry.
- ✗Subjects unable to comply with the study or sample schedule.
See the full criteria
Where Is This Study? (1 UK site)
Royal Marsden NHS Foundation Trust
Chelsea SW3 6JJ, United Kingdom
How to Get in Touch
Laura Boddy
Sponsor contactCONTACT
Arjun Modi
Sponsor contactCONTACT