At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- JNJ-90014496 (biological)
- How long the study runs
- Study runs about 227 months (dates as stated)
- About the drug or intervention
- JNJ-90014496 — biological: JNJ-90014496, an autologous dual targeting chimeric antigen receptor (CAR) - T cell therapy targeting Cluster of differentiation (CD)20 and CD19.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 166
- Started
- 2022-08-12
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for lymphoma, non-hodgkin
- • Phase1/Phase2 - 166 participants
- • This is a Phase 1b/2, multicenter, open-label, study of JNJ-90014496, an autologous dual targeting chimeric antigen receptor (CAR) T-cell therapy targeting both cluster of differentiation (CD) CD20 and CD19, for the treatment of adult participants with relapsed or refractory (r/r) B-Cell non-Hodgkin lymphoma (B-NHL) or frontline high-risk diffuse large B-cell lymphoma (DLBCL)
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with lymphoma, non-hodgkin
Where?
- • London - University College London Hospitals
- • Manchester - The Christie NHS Foundation Trust Christie Hospital
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This is a Phase 1b/2, multicenter, open-label, study of JNJ-90014496, an autologous dual targeting chimeric antigen receptor (CAR) T-cell therapy targeting both cluster of differentiation (CD) CD20 and CD19, for the treatment of adult participants with relapsed or refractory (r/r) B-Cell non-Hodgkin lymphoma (B-NHL) or frontline high-risk diffuse large B-cell lymphoma (DLBCL).
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
What the study is looking for
- ✓Participant must be greater than or equal to (\>=) 18 years of age, at the time of signing agreement to take part
- ✓Tumor must be confirmed by a biopsy cluster of differentiation (CD)19 and/or CD20 positive
- ✓cancer that can be measured on scans as defined by Lugano 2014 classification
- ✓activity scale (ECOG) performance status of 0 to 2
Who cannot take part
- ✗History of causing symptoms deep vein thrombosis or lung embolism within six months of apheresis (line associated...
- ✗History of a seizure disorder, dementia, cerebellar disease or neurodegenerative disorder
- ✗Known history or prior diagnosis of optic neuritis or other immunologic or inflammatory disease affecting the...
- ✗Current active liver or biliary disease (except for Gilbert's syndrome or not causing symptoms gallstones)
- ✗Evidence of active viral or bacterial infection requiring systemic antimicrobial therapy, or uncontrolled systemic...
See the full criteria
Where Is This Study? (2 UK sites)
University College London Hospitals
London NW1 2BU, United Kingdom
Rajinder Sidhu - Associate Director, Research Governance and Operations
uclh.jro-communications@nhs.net020 3447 9825The Christie NHS Foundation Trust Christie Hospital
Manchester M20 4BX, United Kingdom
