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ACTIVE NOT RECRUITINGPhase1/Phase2

A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma

Sponsor: Janssen Research & Development, LLC

NCT ID: NCT05421663

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
JNJ-90014496 (biological)
How long the study runs
Study runs about 227 months (dates as stated)
About the drug or intervention
JNJ-90014496 — biological: JNJ-90014496, an autologous dual targeting chimeric antigen receptor (CAR) - T cell therapy targeting Cluster of differentiation (CD)20 and CD19.
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
18 Years and over
Who
All
Number of participants
166
Started
2022-08-12
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for lymphoma, non-hodgkin
  • • Phase1/Phase2 - 166 participants
  • • This is a Phase 1b/2, multicenter, open-label, study of JNJ-90014496, an autologous dual targeting chimeric antigen receptor (CAR) T-cell therapy targeting both cluster of differentiation (CD) CD20 and CD19, for the treatment of adult participants with relapsed or refractory (r/r) B-Cell non-Hodgkin lymphoma (B-NHL) or frontline high-risk diffuse large B-cell lymphoma (DLBCL)

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with lymphoma, non-hodgkin

Where?

  • • London - University College London Hospitals
  • • Manchester - The Christie NHS Foundation Trust Christie Hospital

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

This is a Phase 1b/2, multicenter, open-label, study of JNJ-90014496, an autologous dual targeting chimeric antigen receptor (CAR) T-cell therapy targeting both cluster of differentiation (CD) CD20 and CD19, for the treatment of adult participants with relapsed or refractory (r/r) B-Cell non-Hodgkin lymphoma (B-NHL) or frontline high-risk diffuse large B-cell lymphoma (DLBCL).

Lymphoma, Non-HodgkinLymphoma, B-CellLymphoma, Large B-Cell, Diffuse

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

Biomarkers mentioned

CD20CD20 positivePR

What the study is looking for

  • ✓Participant must be greater than or equal to (\>=) 18 years of age, at the time of signing agreement to take part
  • ✓Tumor must be confirmed by a biopsy cluster of differentiation (CD)19 and/or CD20 positive
  • ✓cancer that can be measured on scans as defined by Lugano 2014 classification
  • ✓activity scale (ECOG) performance status of 0 to 2

Who cannot take part

  • ✗History of causing symptoms deep vein thrombosis or lung embolism within six months of apheresis (line associated...
  • ✗History of a seizure disorder, dementia, cerebellar disease or neurodegenerative disorder
  • ✗Known history or prior diagnosis of optic neuritis or other immunologic or inflammatory disease affecting the...
  • ✗Current active liver or biliary disease (except for Gilbert's syndrome or not causing symptoms gallstones)
  • ✗Evidence of active viral or bacterial infection requiring systemic antimicrobial therapy, or uncontrolled systemic...
See the full criteria
Inclusion Criteria: * Participant must be greater than or equal to (\>=) 18 years of age, at the time of signing informed consent * Tumor must be histologically confirmed cluster of differentiation (CD)19 and/or CD20 positive * Must meet the indications for each subtype in Phase 1b as specified in protocol and Phase 2 participants must have following: Diagnosis of Large B-cell lymphoma (LBCL), Follicular large B-cell lymphoma (FLBCL), or transformation of indolent lymphoma; Received at least 2 prior lines of systemic therapy; Relapsed or refractory disease defined as 1 or more of the following: Stable disease or Progressive disease (PD) as best response to most recent anti-lymphoma therapy OR disease progression or recurrence after a partial response (PR) or complete response (CR) to most recent anti lymphoma therapy; cohort specific requirements as mentioned in protocol * Measurable disease as defined by Lugano 2014 classification * Eastern cooperative oncology group (ECOG) performance status of 0 to 2 Exclusion Criteria: * History of symptomatic deep vein thrombosis or pulmonary embolism within six months of apheresis (line associated deep vein thrombosis is allowed) * History of stroke, unstable angina, myocardial infarction, congestive heart failure New York Heart Association (NYHA) Class III or IV, severe cardiomyopathy or ventricular arrhythmia requiring medication or mechanical control within 6 months of apheresis * History of a seizure disorder, dementia, cerebellar disease or neurodegenerative disorder * Known history or prior diagnosis of optic neuritis or other immunologic or inflammatory disease affecting the central nervous system * Current active liver or biliary disease (except for Gilbert's syndrome or asymptomatic gallstones) * Evidence of active viral or bacterial infection requiring systemic antimicrobial therapy, or uncontrolled systemic fungal infection * Diagnosis of Human herpes virus (HHV) 8-positive DLBCL or T cell/histiocyte-rich large B-cell lymphoma or Burkitt and high-grade B-cell lymphoma with 11q aberrations (previously Burkitt-like lymphoma) or Richter's transformation or Lymphomatoid granulomatosis or Plasmablastic lymphoma or Waldenstrom's Macroglobulinemia * Any prior solid organ or allogeneic stem cell transplantation * Autologous stem cell transplant within 12 weeks of apheresis; Prior CAR-T cell therapy within 12 weeks of apheresis

Where Is This Study? (2 UK sites)

University College London Hospitals

London NW1 2BU, United Kingdom

Hospital R&D contact (matched)

Rajinder Sidhu - Associate Director, Research Governance and Operations

uclh.jro-communications@nhs.net020 3447 9825

The Christie NHS Foundation Trust Christie Hospital

Manchester M20 4BX, United Kingdom

Hospital R&D contact (matched)

Research and Innovation Office

the-christie.ri@nhs.net---
Data sourced from ClinicalTrials.gov · Last verified: 2026-09