At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- BI 1703880 (drug), Ezabenlimab (drug)
- How long the study runs
- Study runs about 71 months (dates as stated)
- About the drug or intervention
- BI 1703880 — drug: BI 1703880 · Ezabenlimab — drug: Ezabenlimab
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 66
- Started
- 2023-02-24
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for solid tumors
- • Phase1 - 66 participants
- • This study is open to adults with different types of advanced cancer
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with solid tumors
Where?
- • London - The Royal Marsden Hospital, Chelsea
- • Oxford - Churchill Hospital
- • Sutton - The Royal Marsden Hospital, Sutton
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This study is open to adults with different types of advanced cancer. People can take part if previous treatment was not successful, or no treatment exists. The purpose of this study is to find the highest dose of a medicine called BI 1703880 that people with advanced cancer can tolerate when taken together with ezabenlimab. BI 1703880 and ezabenlimab are medicines that may help the immune system fight cancer. In this study, BI 1703880 is given to people for the first time. Participants get BI 1703880 and ezabenlimab as infusions into a vein. During the first 6 weeks, they get BI 1703880 once a week. Later, they get BI 1703880 every 3 weeks. After the first 3 weeks, they get ezabenlimab in addition every 3 weeks. Participants can get BI 1703880 for up to 1 year and ezabenlimab for up to 2 years as long as they benefit from treatment and can tolerate it. During this time, they visit the study site regularly. At these visits, the doctors check participants' health and take note of any unwanted effects.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ at least one measurable lesion (according to Response Criteria in Solid Tumours (RECIST 1
What the study is looking for
- ✓Patient must have exhausted or refused established treatment options for the malignant disease, or is not eligible...
- ✓Has a lesion amenable to pre-treatment and on-treatment biopsy and patient consents to both biopsies.
- ✓Medically fit and willing to undergo all mandatory trial procedures.
- ✓activity scale (ECOG) performance status score of 0 or 1.
- ✓healthy organ or bone marrow health as demonstrated at screening by the following laboratory values:
Who cannot take part
- ✗Any investigational or antitumour treatment within 4 weeks or 5 half-life periods prior to the first treatment...
- ✗Prior STING agonist therapy.
- ✗Prior intolerability of a anti-programmed cell death protein 1 (PD-1) or anti-programmed cell death ligand 1 (PD-L1)...
- ✗History of allergy or hypersensitivity to study agent components.
- ✗Immunosuppressive therapies including, but not limited to, systemic corticosteroids at doses exceeding \>10 mg/day...
See the full criteria
Where Is This Study? (3 UK sites)
The Royal Marsden Hospital, Chelsea
London SW3 6JJ, United Kingdom
Churchill Hospital
Oxford OX3 7LE, United Kingdom
The Royal Marsden Hospital, Sutton
Sutton SM2 5PT, United Kingdom
How to Get in Touch
Boehringer Ingelheim
Sponsor contactCONTACT
