At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Amivantamab (drug), Lazertinib (drug), Carboplatin (drug), Pemetrexed (drug)
- How long the study runs
- Study runs about 69 months (dates as stated)
- About the drug or intervention
- Amivantamab — drug: Amivantamab will be administered subcutaneously by manual injection. · Lazertinib — drug: Lazertinib will be administered as an oral tablet. · Carboplatin — drug: Carboplatin will be administrated by IV infusion. · Pemetrexed — drug: Pemetrexed will be administered by IV infusion. · Direct Oral Anticoagulant (DOAC) — drug: DOAC will be administered orally. · Low Molecular Weight Heparin (LMWH) — drug: LMWH will be administered subcutaneously.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 520
- Started
- 2022-11-11
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for carcinoma, non-small-cell lung
- • Phase2 - 520 participants
- • The purpose of this study is to assess the anti-tumor activity and safety of amivantamab which will be administered as a co-formulation with recombinant human hyaluronidase PH20 (rHuPH20) (subcutaneous co-formulation \[SC-CF\]) in combination treatment (all cohorts except Cohort 4) and to characterize the safety of amivantamab SC-CF (Cohort 4)
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with carcinoma, non-small-cell lung
Where?
- • Cheltenham - Cheltenham General Hospital
- • Devon - Torbay Hospital-Devon
- • Edinburgh - Edinburgh Cancer Centre Western General
- • Leicester - Leicester Royal Infirmary
- • +3 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The purpose of this study is to assess the anti-tumor activity and safety of amivantamab which will be administered as a co-formulation with recombinant human hyaluronidase PH20 (rHuPH20) (subcutaneous co-formulation \[SC-CF\]) in combination treatment (all cohorts except Cohort 4) and to characterize the safety of amivantamab SC-CF (Cohort 4).
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ first-
- ✓ eastern cooperative oncology group (ECOG) status of 0 or 1
What the study is looking for
- ✓Have adequate organ (kidney, liver, blood, coagulation and heart) functions
- ✓Participant must have activity scale (ECOG) status of 0 or 1
Who cannot take part
- ✗Participant has a medical history of interstitial lung disease (ILD), including drug induced ILD or radiation...
- ✗Participant has a history of hypersensitivity to any excipients of the investigational products to be used in their...
- ✗Other clinically active liver disease of infectious origin
See the full criteria
Where Is This Study? (7 UK sites)
Cheltenham General Hospital
Cheltenham GL53 7AN, United Kingdom
Torbay Hospital-Devon
Devon TQ2 7AA, United Kingdom
Edinburgh Cancer Centre Western General
Edinburgh EH4 2XU, United Kingdom
Leicester Royal Infirmary
Leicester LE1 5WW, United Kingdom
Carolyn Maloney
uhl-tr.researchandinnovationadminmailbox@nhs.net0116 258 8351University College London Hospitals
London NW1 2PG, United Kingdom
Rajinder Sidhu - Associate Director, Research Governance and Operations
uclh.jro-communications@nhs.net020 3447 9825Nottingham City Hospital
Nottingham NG5 1PB, United Kingdom
Queen Alexandra Hospital
Portsmouth PO6 3LY, United Kingdom
How to Get in Touch
Study Contact
Sponsor contactCONTACT
