At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- mezigdomide (drug), Pomalidomide (drug), Bortezomib (drug), Dexamethasone (drug)
- How long the study runs
- Study runs about 134 months (dates as stated)
- About the drug or intervention
- mezigdomide — drug: Specified dose on specified days · Pomalidomide — drug: Specified dose on specified days · Bortezomib — drug: Specified dose on specified days · Dexamethasone — drug: Specified dose on specified days
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 810
- Started
- 2022-09-20
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for relapsed or refractory multiple myeloma
- • Phase3 - 810 participants
- • The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with relapsed or refractory multiple myeloma
Where?
- • Cambridge - Addenbrooke's Hospital
- • Truro - The Royal Cornwall Hospital
- • Airdrie - Lanarkshire NHS Trust - Monklands Hospital
- • London - King's College Hospital
- • +5 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Treatment history
Treatments you must have had:
- ✓ of a b
- ✓ mezigdomide
What the study is looking for
- ✓Inclusion Criteria
- ✓\- Participant has documented diagnosis of MM and cancer that can be measured on scans, defined as any of the following:.
- ✓i) M-protein ≥ 0.5 grams per deciliter (g/dL) by serum protein electrophoresis (sPEP) or.
- ✓ii) M-protein ≥ 200 milligrams (mg) per 24-hour urine collection by urine protein electrophoresis (uPEP).
- ✓iii) For participants without cancer that can be measured on scans in sPEP or uPEP: serum free light chain (sFLC) levels \> 100 mg/L...
See the full criteria
Where Is This Study? (9 UK sites)
Addenbrooke's Hospital
Cambridge CB2 0QQ, United Kingdom
The Royal Cornwall Hospital
Truro TR1 3LJ, United Kingdom
Lanarkshire NHS Trust - Monklands Hospital
Airdrie ML6 OJS, United Kingdom
King's College Hospital
London SE5 9RS, United Kingdom
Leicester Royal Infirmary
Leicester LE1 5WW, United Kingdom
Hammersmith Hospital
London W12 0HS, United Kingdom
Barnet Hospital
Barnet EN5 3DJ, United Kingdom
Freeman Hospital
Newcastle upon Tyne NE7 7DN, United Kingdom
Royal Stoke University Hospital
Stoke-on-Trent ST4 6QG, United Kingdom
How to Get in Touch
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
Sponsor contactCONTACT
First line of the email MUST contain NCT # and Site #.
Sponsor contactCONTACT
