At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Not specified by the sponsor
- How long the study runs
- Study runs about 50 months (dates as stated)
- About the drug or intervention
- Not specified by the sponsor
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Observing health over time
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 12
- Started
- 2022-10-29
- Last checked
- 2026-05
Plain English Summary
What is this study?
- • Testing a new treatment for iron-deficiency
- • Clinical study - 12 participants
- • The aim of this study is to track where the iron goes in different tissues in the hours, days and weeks after an intravenous iron infusion
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with iron-deficiency
Where?
- • Oxford - Oxford Centre for Clinical Magnetic Resonance Research (OCMR)
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The aim of this study is to track where the iron goes in different tissues in the hours, days and weeks after an intravenous iron infusion. We will track iron in tissues using MRI relaxometry parameters R1/R2/R2\* which are well established as accurate indicators of tissue iron content.
More detail
This is a prospective, observational, study exploring the kinetics of tissue iron uptake following intravenous iron infusion (Ferinject), received as part of standard clinical care in a group of iron-deficient patients. Participants will be recruited through the Iron Deficiency Management Service, part of the Oxford University Hospitals NHS Foundation Trust (OUHFT) . Participants will receive their intravenous iron infusion (Ferinject) as part of their standard clinical care by an NHS clinician. They will undergo all the study MRI scans and additional study procedures at the Oxford Centre for Clinical Magnetic Resonance Research (OCMR), which is based at the John Radcliffe Hospital and is part of the Division of Cardiovascular Medicine within the Radcliffe Department of Medicine at the University of Oxford. Each participant will undergo 4 MRI scans; baseline, 3hours, 14 days and 42 days post intravenous iron infusion. Blood samples will also be collected at those timepoints for assessment of relevant heamatological and iron parameters.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓Participant is willing and able to give agreement to take part for participation in the study.
- ✓Aged 18 years or above.
- ✓Anaemia (haemoglobin less than 120g/L for women and less than 130g/L for men) and/or confirmed iron deficiency...
- ✓Scheduled to receive intravenous iron for correction of iron deficiency.
Who cannot take part
- ✗Any MRI incompatible implants (e.g. heart, neuro, ocular implants, surgical clips, aneurysm clips, shrapnel/bullets)
- ✗Pregnant or lactating participant
- ✗Acute decompensated heart failure
- ✗Unstable clinical status
- ✗Any other medical conditions which would influence the reliability of the study results determined by the investigators.
See the full criteria
Where Is This Study? (1 UK site)
Oxford Centre for Clinical Magnetic Resonance Research (OCMR)
Oxford OX3 9DU, United Kingdom