At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- JNJ-79635322 (drug)
- How long the study runs
- Study runs about 96 months (dates as stated)
- About the drug or intervention
- JNJ-79635322 — drug: JNJ-79635322 will be administered as SC injection.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 180
- Started
- 2022-11-22
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for relapsed or refractory multiple myeloma
- • Phase1 - 180 participants
- • The primary purpose of this study is to identify the recommended phase 2 dose (RP2D\[s\]) and schedule(s) to be safe for JNJ-79635322 in Part 1 (dose escalation), and to characterize the safety and tolerability of JNJ-79635322 at the RP2D(s) selected and in disease subgroups in Part 2 (dose expansion)
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with relapsed or refractory multiple myeloma
Where?
- • London - University College Hospital
- • Sutton - Royal Marsden Hospital
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The primary purpose of this study is to identify the recommended phase 2 dose (RP2D\[s\]) and schedule(s) to be safe for JNJ-79635322 in Part 1 (dose escalation), and to characterize the safety and tolerability of JNJ-79635322 at the RP2D(s) selected and in disease subgroups in Part 2 (dose expansion).
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ an Eastern Cooperative Oncology Group (ECOG) status of 0 or 1
- ✓ to have measurable disease)
- ✓ of therapy
What the study is looking for
- ✓For participants with relapsed or refractory multiple myeloma:
- ✓Have a documented initial diagnosis of multiple myeloma according to International Myeloma Working Group (IMWG)...
- ✓Must have an activity scale (ECOG) status of 0 or 1
- ✓For participants with previously treated AL amyloidosis:
- ✓Initial histopathological diagnosis of amyloidosis
Who cannot take part
- ✗For participants with relapsed or refractory multiple myeloma:
- ✗Central Nervous System (CNS) involvement or clinical signs of meningeal involvement of multiple myeloma. If either...
- ✗Active plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome (polyneuropathy, organomegaly,...
- ✗Received a cumulative dose of corticosteroids equivalent to greater than (\>) 140 mg of prednisone within the 14-day...
- ✗Prior allogeneic transplant within 6 months before the start of study treatment administration or autologous...
See the full criteria
Where Is This Study? (2 UK sites)
University College Hospital
London W1T 7HA, United Kingdom
Rajinder Sidhu - Associate Director, Research Governance and Operations
uclh.jro-communications@nhs.net020 3447 9825Royal Marsden Hospital
Sutton SM2 5PT, United Kingdom
How to Get in Touch
Study Contact
Sponsor contactCONTACT
