At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Physiology-guided NCL PCI (procedure), Angiography-guided NCL PCI (procedure)
- How long the study runs
- Study runs about 60 months (dates as stated)
- About the drug or intervention
- Physiology-guided NCL PCI — procedure: For RFR, PCI will be performed as per local practice for all lesions with RFR ≤0.89. · Angiography-guided NCL PCI — procedure: PCI will be performed as per local practice
- Patient visit burden
- Not specified by the sponsor
In plain English
This study looks at people who have had a heart attack (acute myocardial infarction) caused by a blocked heart artery, and who also have other narrowed heart arteries. It compares two ways of deciding which of these other narrowings need treatment with a procedure called PCI (percutaneous coronary intervention, which uses a small balloon and usually a stent to open the artery).
Who can take part
- You had a STEMI or type 1 NSTEMI heart attack and had the artery that caused it successfully opened with PCI within the past 72 hours
- You have at least one more narrowed heart artery that could be treated with PCI, is narrowed by at least 50%, and is at least 2.5 mm wide
- Your doctors plan to fully treat all the remaining narrowed arteries for this heart attack
Who may not be able to
- You have had, or are planning to have, heart bypass surgery (CABG)
- Doctors cannot clearly identify which artery caused your heart attack
- You had PCI on a different narrowed artery within 45 days before joining the study
- Your doctors plan to treat all the other narrowed areas with medicines only, not PCI
- One of the other narrowed areas is very severe (more than 90% narrowed) or blood flow through it is reduced
- Your only other narrowed artery is completely blocked long-term (a chronic total occlusion) — though you can join if you have this plus other treatable narrowings
- The only other narrowed artery is in the same artery as the one that caused your heart attack
- Your heart attack was caused by something other than the usual fatty-plaque process (for example a tear in the artery or a blockage from a clot elsewhere)
- You have another illness that means you are expected to live less than 2 years
- Any other medical, travel, or personal reason that would make taking part or 5 years of check-ups impractical
What taking part involves
- • The study compares two ways of deciding how to treat the other narrowed heart arteries, but the exact procedures are not described in the registry data — ask the trial team
Time commitment: Not stated — ask the trial team (the data mentions 5 years of follow-up, but visit details are not given).
Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 5,100
- Started
- 2023-06-22
- Last checked
- 2025-06
Plain English Summary
What is this study?
- • Testing a new treatment for acute myocardial infarction
- • NA - 5,100 participants
- • COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI)
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with acute myocardial infarction
Where?
- • Ashford - East Kent Hospitals University NHS Foundation Trust
- • Blackpool - Blackpool Teaching Hospitals
- • Dundee - Ninewells Hospital
- • Harefield - Harefield Hospital
- • +15 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI). COMPLETE-2 OCT is a large scale, prospective, multi-centre, observational, imaging study of patients with STEMI or NSTEMI and multivessel CAD in a subset of eligible COMPLETE-2 patients.
More detail
COMPLETE-2 STUDY OBJECTIVES 1. To determine whether a strategy of physiology-guided complete revascularization is non-inferior to a strategy of angiography-guided complete revascularization on the efficacy composite outcome of cardiovascular (CV) death, new myocardial infarction (MI) or ischemia-driven revascularization (IDR). 2. To determine whether a physiology-guided complete revascularization strategy is superior to an angiography-guided complete revascularization strategy in reducing the safety composite outcome of clinically significant bleeding, stroke, stent thrombosis or contrast-associated acute kidney injury.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓Patients presenting with STEMI or type 1 NSTEMI and within 72 hours of successful culprit-lesion PCI
- ✓Residual coronary artery disease defined as at least 1 additional non-infarct-related coronary artery stenosis that...
- ✓Amenable to successful treatment with PCI
- ✓At least 50% diameter stenosis by visual estimation
- ✓At least 2.5 mm in diameter
Who cannot take part
- ✗Planned or prior coronary artery bypass graft (CABG) surgery
- ✗Inability to clearly identify a culprit lesion for STEMI or NSTEMI based on angiographic appearance and/or ECG...
- ✗Prior PCI of a non-culprit lesion in a different vessel from the culprit lesion within 45 days of randomization
- ✗Planned medical treatment of all qualifying non-culprit lesions (i.e., no PCI)
- ✗Presence of severe non-culprit-lesion stenosis with reduced epicardial flow (TIMI flow ≤ 2) or \>90% visual diameter...
See the full criteria
Where Is This Study? (19 UK sites)
East Kent Hospitals University NHS Foundation Trust
Ashford, United Kingdom
Blackpool Teaching Hospitals
Blackpool, United Kingdom
Ninewells Hospital
Dundee, United Kingdom
Harefield Hospital
Harefield, United Kingdom
Kettering General Hospital
Kettering, United Kingdom
University Hospitals of Leicester
Leicester, United Kingdom
Liverpool Heart and Chest Hospital
Liverpool, United Kingdom
Barts Health NHS Trust
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
Royal Free London NHS Foundation Trust
London, United Kingdom
Manchester University NHS Foundation Trust
Manchester, United Kingdom
The James Cook University Hospital
Middlesbrough, United Kingdom
Freeman Hospital
Newcastle upon Tyne, United Kingdom
Royal Berkshire Foundation NHS Trust
Reading, United Kingdom
Sheffield Teaching Hospitals
Sheffield, United Kingdom
East and North Hertfordshire NHS Trust
Stevenage, United Kingdom
Royal Cornwall Hospitals NHS Trust
Truro, United Kingdom
The Royal Wolverhampton NHS Trust
Wolverhampton, United Kingdom
Worcestershire Acute Hospitals NHS Trust
Worcester, United Kingdom
How to Get in Touch
COMPLETE-2 Project Office
Sponsor contactCONTACT