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Diagnosing Variable Primary Aldosteronism.

Sponsor: Queen Mary University of London

NCT ID: NCT05765786

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Health checks and monitoring — no treatment given
Type of study
Observational (no treatment given)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Not specified by the sponsor
How long the study runs
Study runs about 53 months (dates as stated)
About the drug or intervention
Not specified by the sponsor
Patient visit burden
Not specified by the sponsor
Type of study
Observing health over time
Ages
18 Years and over
Who
All
Number of participants
100
Started
2023-02-24
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for primary aldosteronism
  • • Clinical study - 100 participants
  • • The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with primary aldosteronism

Where?

  • • London - Queen Mary University of London

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.

More detail

The main questions it aims to answer are: * Can we diagnose more people if we used 24 hour urine measurements? * In those with high amounts of aldosterone in their urine, is there a variable pattern to their aldosterone production? Participants will have a 24 hour urine measurement. They will also have multiple blood tests throughout the day to study the variability in aldosterone secretion.

Primary AldosteronismHigh Blood Pressure

How this trial compares with your answers

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What we know so far

Condition· Matched your search
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Still need:

  • • Tell us your age for better matching
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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

Biomarkers mentioned

met

What the study is looking for

  • ✓Patients who have been diagnosed with PA and had previous aldosterone samples \<277 pmol/L, a level which would...
  • ✓Patients with aldosterone results done at different times that indicate variability in production.
  • ✓Willing to consent and participate in the study.

Who cannot take part

  • ✗Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks.
  • ✗People on end of life treatment.
See the full criteria
Inclusion Criteria: * People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity \<0.5 nmol/h/L or renin mass \<5 ng/L), plasma sodium \> 140mmol/L or plasma potassium \< 4mmol/L. * Patients who have been diagnosed with PA and had previous aldosterone samples \<277 pmol/L, a level which would normally not qualify for confirmatory testing. * Patients with aldosterone results done at different times that indicate variability in production. * Willing to consent and participate in the study. Exclusion Criteria: * Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks. * People on end of life treatment.

Where Is This Study? (1 UK site)

Queen Mary University of London

London, United Kingdom

Recruiting
Site contact (verified)

How to Get in Touch

Yun Ni Lee

Sponsor contact

CONTACT

+442078827275 y.n.lee@qmul.ac.uk

Tumi Kaminskas

Sponsor contact

CONTACT

+442078827275 research.governance@qmul.ac.uk
Data sourced from ClinicalTrials.gov · Last verified: 2026-09