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ACTIVE NOT RECRUITINGPhase3

A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

Sponsor: Bristol-Myers Squibb

NCT ID: NCT05827016

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Iberdomide (drug), Lenalidomide (drug)
How long the study runs
Study runs about 151 months (dates as stated)
About the drug or intervention
Iberdomide — drug: Specified dose on specified days · Lenalidomide — drug: Specified dose on specified days
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
18 Years and over
Who
All
Number of participants
1,230
Started
2023-06-22
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for multiple myeloma
  • • Phase3 - 1,230 participants
  • • The purpose of this study is to compare the effectiveness of iberdomide maintenance to lenalidomide maintenance therapy after autologous stem cell transplantation (ASCT) in participants with newly diagnosed multiple myeloma (NDMM)

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with multiple myeloma

Where?

  • • Aberdeen - Local Institution - 0173
  • • Windsor - Local Institution - 0161
  • • Derby - Local Institution - 0156
  • • Bournemouth - Local Institution - 0162
  • • +5 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this study is to compare the effectiveness of iberdomide maintenance to lenalidomide maintenance therapy after autologous stem cell transplantation (ASCT) in participants with newly diagnosed multiple myeloma (NDMM).

Multiple Myeloma

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

Biomarkers mentioned

CD38PR

What the study is looking for

  • ✓Inclusion Criteria
  • ✓Confirmed diagnosis of causing symptoms multiple myeloma (MM).
  • ✓activity scale performance status (ECOG) score of 0, 1, or 2.
  • ✓Exclusion Criteria
  • ✓Progressive disease or clinical relapse (as defined by IMWG response criteria) following ASCT with or without...
See the full criteria
Inclusion Criteria * Confirmed diagnosis of symptomatic multiple myeloma (MM). * Eastern Cooperative Oncology Group performance status (ECOG) score of 0, 1, or 2. * Received 3 to 6 cycles of an induction therapy that includes a proteasome inhibitor (PI) and immunomodulatory (IMiD) \[eg, bortezomib thalidomide and dexamethasone (VTd), lenalidomide, bortezomib and dexamethasone (RVd)\] with or without a CD38 monoclonal antibody, daratumumab + bortezomib/thalidomide/dexamethasone \[D-VTd\] and daratumumab + bortezomib/ lenalidomide/dexamethasone \[D-VRd\]), or VCd / daratumumab + bortezomib/cyclophosphamide/dexamethasone \[D-VCd\], and followed by a single or tandem autologous stem cell transplantation (ASCT). Post-stem cell transplant consolidation is permitted. * Participants within 12 months (single transplant) or 15 months (tandem transplant) from initiation of induction therapy who achieved at least a partial response (PR) after autologous stem cell transplantation (ASCT) with or without consolidation, according to International Myeloma Working Group (IMWG 2016) criteria. Exclusion Criteria * Progressive disease or clinical relapse (as defined by IMWG response criteria) following ASCT with or without consolidation or is not responsive to primary therapy. * Smoldering myeloma, solitary plasmacytoma or nonsecretory myeloma. * Known central nervous system/meningeal involvement of MM. * Prior history of malignancies, other than MM, unless the participant has been free of the disease for ≥ 5 years. * Other protocol-defined Inclusion/Exclusion criteria apply.

Where Is This Study? (9 UK sites)

Local Institution - 0173

Aberdeen AB25 2ZN, United Kingdom

Local Institution - 0161

Windsor SL4 3HD, United Kingdom

Local Institution - 0156

Derby DE22 3NE, United Kingdom

Local Institution - 0162

Bournemouth BH7 7DW, United Kingdom

Local Institution - 0284

Portsmouth PO6 3LY, United Kingdom

Local Institution - 0154

Stoke-on-Trent ST4 6QG, United Kingdom

Local Institution - 0160

Edinburgh EH4 2XU, United Kingdom

Local Institution - 0025

London W1G 6AF, United Kingdom

Local Institution - 0029

Oxford OX4 6LB, United Kingdom

Data sourced from ClinicalTrials.gov · Last verified: 2026-09