At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Time restricted eating (behavioural), Extended eating window (behavioural), Healthy diet (behavioural)
- How long the study runs
- Study runs about 57 months (dates as stated)
- About the drug or intervention
- Time restricted eating — behavioural: Participants assigned to the TRE group will have to consume all their daily meals and snacks during a 9-hour window for 12 weeks. · Extended eating window — behavioural: Participants assigned to the control group will have to consume all their daily meals and snacks during a 14-hour window for 12 weeks. · Healthy diet — behavioural: Participants will be provided nutrition education and counselling to follow a diet consistent with the existing guidelines for chronic disease prevention.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 25 Years to 75 Years
- Who
- All
- Number of participants
- 100
- Started
- 2023-11-01
- Last checked
- 2026-05
Plain English Summary
What is this study?
- • Testing a new treatment for obesity
- • NA - 100 participants
- • Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day
Who can take part?
- • Ages 25 Years to 75 Years
- • Diagnosed with obesity
Where?
- • Cambridge - Cambridge Clinical Research Center
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day. In rodents, TRE improves metabolic function without caloric restriction, potentially by activating nutrient sensing mechanisms and effects on circadian oscillations. However, an understanding of the effect of TRE on cardiometabolic health in people is not clear and few studies have evaluated this issue. Accordingly, the investigators propose to conduct a randomized controlled trial in people with obesity and prediabetes to determine the effect of 9 h TRE for 12 weeks, without a change in body weight, on key metabolic outcomes that are risk factors for cardiovascular disease (CVD): 1) multi-organ insulin sensitivity; 2) 24 h metabolic homeostasis and diurnal rhythm; and 3) adipose tissue and skeletal muscle biology. The proposed studies will elucidate the cardiometabolic implications of TRE in people with obesity and prediabetes.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 25 Years - 75 Years
- Who can join: All genders
What the study is looking for
- ✓must be able to grant voluntary agreement to take part and comply with the study instructions
- ✓aged 25-75 years
- ✓men and women
- ✓body mass index 27-45 kg/m2
- ✓self-reported habitual eating period ≥ 13 h per day
Who cannot take part
- ✗shift worker
- ✗fasting \>12 h/day more than once a week
- ✗\> once a week no food intake after \~1800 h
- ✗habitually waking up before \~0400 h and sleeping before \~2100 h
- ✗unstable weight (\>5% change the last 2 months)
See the full criteria
Where Is This Study? (1 UK site)
Cambridge Clinical Research Center
Cambridge CB2 0QQ, United Kingdom
How to Get in Touch
Maria Chondronikola
Sponsor contactCONTACT