At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Not specified by the sponsor
- How long the study runs
- Study runs about 36 months (dates as stated)
- About the drug or intervention
- Not specified by the sponsor
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Observing health over time
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 10,000
- Started
- 2023-09-25
- Last checked
- 2024-12
Plain English Summary
What is this study?
- • Testing a new treatment for opioid use
- • Clinical study - 10,000 participants
- • The aim of this study is to document the perioperative opioid use and its safety in the UK and countries in Europe and to describe its association with surgical complications, persistent pain and quality of life
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with opioid use
Where?
- • Aberdeen - NHS Grampian
- • London - University College London Hospitals NHS Foundation Trust
- • Nottingham - Kings Mill Hospital, Sherwood Forest Hospitals NHS Foundation Trust
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The aim of this study is to document the perioperative opioid use and its safety in the UK and countries in Europe and to describe its association with surgical complications, persistent pain and quality of life. In an international, prospective, observational cohort study, data about the perioperative pain management will be collected in all eligible hospitalised adult patients who undergo surgery in a designated "study week" in as many hospitals as possible in Europe. Baseline data will be collected, and participants followed up at one week, and at three and twelve months post-operatively. The primary outcome will be opioid use at three months after surgery. Secondary outcomes will include opioid use during the preoperative month (preoperative use), during surgery and up to one week after surgery (or discharge, whichever is earlier), and up to the end of the postoperative year. Additional secondary outcomes are the incidence of preoperative pain, persistent pain with/without the presence of neuropathic components, quality of life and surgical complications. The potential association between opioid use and pain outcomes will be investigated. This study could help to develop strategies to improve quality of care, through pain management, for patients undergoing surgery.
More detail
PANDOS is an international, prospective, observational cohort study. In a one week period (the designated "study week"), data will be collected in all eligible hospitalised adult patients who undergo surgery in as many hospitals as possible in the UK and Europe. Participants will be followed up for 12 months
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓Able to understand and has capacity to give written agreement to take part
Who cannot take part
- ✗American Society of Anaesthesiologists (ASA) grade V or VI
- ✗Refusal to participate.
- ✗Lack of comprehension of validated questionnaires or inability to complete the follow-up for any reason.
- ✗Lack of capacity to give written agreement to take part
See the full criteria
Where Is This Study? (3 UK sites)
NHS Grampian
Aberdeen, United Kingdom
University College London Hospitals NHS Foundation Trust
London, United Kingdom
Rajinder Sidhu - Associate Director, Research Governance and Operations
uclh.jro-communications@nhs.net020 3447 9825Kings Mill Hospital, Sherwood Forest Hospitals NHS Foundation Trust
Nottingham, United Kingdom
How to Get in Touch
Patrice Forget
Sponsor contactCONTACT
Holly R Keir, PhD
Sponsor contactCONTACT