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Looking for participantsPhase2

A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer

Sponsor: Eli Lilly and Company

NCT ID: NCT05999994

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Ramucirumab (drug), Cyclophosphamide (drug), Vinorelbine (drug), Gemcitabine (drug)
How long the study runs
Study runs about 88 months (dates as stated)
About the drug or intervention
Ramucirumab — drug: Administered IV · Cyclophosphamide — drug: Administered orally · Vinorelbine — drug: Administered IV · Gemcitabine — drug: Administered IV · Docetaxel — drug: Administered IV · Abemaciclib — drug: Administered orally · Irinotecan — drug: Administered IV · Temozolomide — drug: Administered orally
Patient visit burden
Not specified by the sponsor

In plain English

This is a 'master protocol' study, which means one main plan that covers several separate clinical trials of cancer drugs for children, teenagers and young adults. It is run by Eli Lilly and Company. Not stated which specific drugs or cancer types are being tested — ask the trial team.

Who can take part

  • Have cancer that can be measured or assessed using standard checks (RECIST 1.1 — a standard way to measure tumours)
  • Be well enough day-to-day, shown by a score of at least 50 on a performance scale (Lansky for under 16s, Karnofsky for 16 and over)
  • Have stopped all previous cancer treatments or experimental drugs at least 7 days before, and have recovered from significant side effects
  • Have blood, bone marrow and organs (such as liver and kidneys) working well enough
  • If female and able to have children: have a negative pregnancy test (urine or blood) within 7 days before the first dose
  • If able to have children (female or male): agree to use highly effective contraception during the trial and for at least 3 months after the last dose

Who may not be able to

  • Have a severe or uncontrolled illness, mental health problem or social situation that could cause safety risks or make it hard to follow the study plan
  • Have an infection that needs treatment
  • Have had a bone marrow transplant from a donor, or a solid organ transplant
  • Have had, or plan to have, certain invasive procedures
  • Are pregnant or breastfeeding

What taking part involves

  • • Taking a study drug — the specific drugs are not stated; ask the trial team
  • • Extra criteria may apply depending on which part (addendum) of the study you join

Time commitment: Not stated — ask the trial team about how many visits, how long the trial lasts and what taking part involves.

Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.

Type of study
Testing a treatment
Ages
1 Year to 39 Years
Who
All
Number of participants
105
Started
2020-01-22
Last checked
2026-08

Plain English Summary

What is this study?

  • • Testing a new treatment for neoplasms
  • • Phase2 - 105 participants
  • • The main purpose of the master is to help the research sites and sponsor carry out several clinical trials more efficiently by providing a common research protocol

Who can take part?

  • • Ages 1 Year to 39 Years
  • • Diagnosed with neoplasms

Where?

  • • London - University College Hospital - London
  • • London - Royal Marsden Hospital
  • • London - Royal Marsden Hospital
  • • Manchester - Royal Manchester Children's Hospital
  • • +1 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The main purpose of the master is to help the research sites and sponsor carry out several clinical trials more efficiently by providing a common research protocol. Individual clinical trials under this master protocol define drug/disease-specific research goals and activities to test them. New studies will be added as new drugs emerge against different cancers. Participation in the trial will depend on how long the benefit lasts.

NeoplasmsChildAdolescent

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 1 Year - 39 Years
  • Who can join: All genders

Biomarkers mentioned

have a negative

Treatment history

Treatments you must have had:

  • ✓ a negative urine or serum pregnancy test within 7 days

What the study is looking for

  • ✓Participants must meet all of the inclusion criteria below. Additional criteria are specified in the protocol...
  • ✓Have either measurable or evaluable disease using standard techniques by the Response Evaluation Criteria in Solid...
  • ✓The participant has a Lansky (\<16 years of age) or Karnofsky (≥16 years of age) performance score of at least 50.
  • ✓The participant has adequate blood and organ health.
  • ✓Female participants of childbearing potential must have a negative urine or serum pregnancy test within 7 days prior...
See the full criteria
Inclusion Criteria: Participants must meet all of the inclusion criteria below. Additional criteria are specified in the protocol amendment (individual addenda) to which the participant will enroll. * Have either measurable or evaluable disease using standard techniques by the Response Evaluation Criteria in Solid Tumors, Version 1.1 (RECIST 1.1). * The participant has a Lansky (\<16 years of age) or Karnofsky (≥16 years of age) performance score of at least 50. * Participants must have discontinued all previous treatments for cancer or investigational agents greater than or equal to (≥)7 days after the last dose and must have recovered from clinically significant side effects. * The participant has adequate hematologic and organ function. * Female participants of childbearing potential must have a negative urine or serum pregnancy test within 7 days prior to first dose. * Both female and male participants of childbearing potential must agree to use highly effective contraceptive precautions during the trial and for at least 3 months following the last dose of study drug. Participants will be ineligible if they meet any of the exclusion criteria below. Additional criteria are specified in the protocol amendment to which the participant will enroll. * Participants with severe and/or uncontrolled concurrent medical disease or psychiatric illness/social situation that, in the opinion of the investigator, could cause unacceptable safety risks or compromise compliance with the protocol. * Participants who have active infections requiring therapy. * Participants who have had allogeneic bone marrow or solid organ transplant. * Participants who have had, or are planning to have, certain invasive procedures. * Female participants who are pregnant or breastfeeding.

Where Is This Study? (5 UK sites)

University College Hospital - London

London NW1 2PG, United Kingdom

Recruiting
Site contact (verified)
Sandra StraussPrincipal Investigator

Royal Marsden Hospital

London SW3 6JJ, United Kingdom

Recruiting
Site contact (verified)
Julia ChisholmPrincipal Investigator

Royal Marsden Hospital

London SW3 6JJ, United Kingdom

Recruiting
Site contact (verified)
ROBIN JONESPrincipal Investigator

Royal Manchester Children's Hospital

Manchester M13 9WL, United Kingdom

Recruiting
Site contact (verified)
Bernadette BrennanPrincipal Investigator

The Christie NHS Foundation Trust

Manchester M20 4BX, United Kingdom

Recruiting
Site contact (verified)
Martin McCabePrincipal Investigator

How to Get in Touch

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

Sponsor contact

CONTACT

1-317-615-4559 LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact

Sponsor contact

CONTACT

clinical_inquiry_hub@lilly.com
Data sourced from ClinicalTrials.gov · Last verified: 2026-08