At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Ramucirumab (drug), Cyclophosphamide (drug), Vinorelbine (drug), Gemcitabine (drug)
- How long the study runs
- Study runs about 88 months (dates as stated)
- About the drug or intervention
- Ramucirumab — drug: Administered IV · Cyclophosphamide — drug: Administered orally · Vinorelbine — drug: Administered IV · Gemcitabine — drug: Administered IV · Docetaxel — drug: Administered IV · Abemaciclib — drug: Administered orally · Irinotecan — drug: Administered IV · Temozolomide — drug: Administered orally
- Patient visit burden
- Not specified by the sponsor
In plain English
This is a 'master protocol' study, which means one main plan that covers several separate clinical trials of cancer drugs for children, teenagers and young adults. It is run by Eli Lilly and Company. Not stated which specific drugs or cancer types are being tested — ask the trial team.
Who can take part
- Have cancer that can be measured or assessed using standard checks (RECIST 1.1 — a standard way to measure tumours)
- Be well enough day-to-day, shown by a score of at least 50 on a performance scale (Lansky for under 16s, Karnofsky for 16 and over)
- Have stopped all previous cancer treatments or experimental drugs at least 7 days before, and have recovered from significant side effects
- Have blood, bone marrow and organs (such as liver and kidneys) working well enough
- If female and able to have children: have a negative pregnancy test (urine or blood) within 7 days before the first dose
- If able to have children (female or male): agree to use highly effective contraception during the trial and for at least 3 months after the last dose
Who may not be able to
- Have a severe or uncontrolled illness, mental health problem or social situation that could cause safety risks or make it hard to follow the study plan
- Have an infection that needs treatment
- Have had a bone marrow transplant from a donor, or a solid organ transplant
- Have had, or plan to have, certain invasive procedures
- Are pregnant or breastfeeding
What taking part involves
- • Taking a study drug — the specific drugs are not stated; ask the trial team
- • Extra criteria may apply depending on which part (addendum) of the study you join
Time commitment: Not stated — ask the trial team about how many visits, how long the trial lasts and what taking part involves.
Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.
- Type of study
- Testing a treatment
- Ages
- 1 Year to 39 Years
- Who
- All
- Number of participants
- 105
- Started
- 2020-01-22
- Last checked
- 2026-08
Plain English Summary
What is this study?
- • Testing a new treatment for neoplasms
- • Phase2 - 105 participants
- • The main purpose of the master is to help the research sites and sponsor carry out several clinical trials more efficiently by providing a common research protocol
Who can take part?
- • Ages 1 Year to 39 Years
- • Diagnosed with neoplasms
Where?
- • London - University College Hospital - London
- • London - Royal Marsden Hospital
- • London - Royal Marsden Hospital
- • Manchester - Royal Manchester Children's Hospital
- • +1 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The main purpose of the master is to help the research sites and sponsor carry out several clinical trials more efficiently by providing a common research protocol. Individual clinical trials under this master protocol define drug/disease-specific research goals and activities to test them. New studies will be added as new drugs emerge against different cancers. Participation in the trial will depend on how long the benefit lasts.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 1 Year - 39 Years
- Who can join: All genders
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ a negative urine or serum pregnancy test within 7 days
What the study is looking for
- ✓Participants must meet all of the inclusion criteria below. Additional criteria are specified in the protocol...
- ✓Have either measurable or evaluable disease using standard techniques by the Response Evaluation Criteria in Solid...
- ✓The participant has a Lansky (\<16 years of age) or Karnofsky (≥16 years of age) performance score of at least 50.
- ✓The participant has adequate blood and organ health.
- ✓Female participants of childbearing potential must have a negative urine or serum pregnancy test within 7 days prior...
See the full criteria
Where Is This Study? (5 UK sites)
University College Hospital - London
London NW1 2PG, United Kingdom
Royal Marsden Hospital
London SW3 6JJ, United Kingdom
Royal Marsden Hospital
London SW3 6JJ, United Kingdom
Royal Manchester Children's Hospital
Manchester M13 9WL, United Kingdom
The Christie NHS Foundation Trust
Manchester M20 4BX, United Kingdom
How to Get in Touch
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Sponsor contactCONTACT
Physicians interested in becoming principal investigators please contact
Sponsor contactCONTACT
