At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Finerenone (drug), Placebo (drug)
- How long the study runs
- Study runs about 47 months (dates as stated)
- About the drug or intervention
- Finerenone — drug: Oral finerenone · Placebo — drug: Matching oral placebo
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 5,200
- Started
- 2024-01-17
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for heart failure
- • Phase3 - 5,200 participants
- • Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with heart failure
Where?
- • Brighton - Brighton, East Sussex Investigative Site 39021
- • Southampton - Southampton, Hampshire Investigative Site 39006
- • Ashford - Ashford, Kent Investigative Site 39020
- • Liverpool - Liverpool, Liverpool Investigative Site 39024
- • +14 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.
More detail
This is an international, randomized, double-blind, placebo-controlled, event-driven trial of finerenone for the treatment of hospitalized heart failure patients with mildly reduced or preserved ejection fraction.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
What the study is looking for
- ✓Provide written agreement to take part
- ✓Age ≥18 years or legal age of majority if \>18 years in the participant's country of residence
- ✓Current hospitalization or recently discharged (during or within 30 days of discharge) with the primary diagnosis of...
- ✓Heart failure signs and symptoms at the time of hospital admission
- ✓Imaging evidence of mildly reduced or preserved left ventricular ejection fraction (EF) (40% or higher)
Who cannot take part
- ✗Current or planned long-term treatment with a mineralocorticoid receptor antagonist (MRA)
- ✗Documented prior history of severe hyperkalemia in the setting of MRA use
- ✗Estimated glomerular filtration rate (eGFR) \<25 mL/min/1.73m² or potassium \>5.0 mmol/L at screening
- ✗Acute myocardial infarction due to plaque rupture, coronary revascularization, valve replacement/repair, or...
- ✗Hemodynamically significant (severe) uncorrected primary heart valvular disease
See the full criteria
Where Is This Study? (18 UK sites)
Brighton, East Sussex Investigative Site 39021
Brighton BN2 1ES, United Kingdom
Southampton, Hampshire Investigative Site 39006
Southampton SO16 6YD, United Kingdom
Ashford, Kent Investigative Site 39020
Ashford TN02 0LZ, United Kingdom
Liverpool, Liverpool Investigative Site 39024
Liverpool L9 7AL, United Kingdom
Chester, North West England Investigative Site 39022
Chester CH2 1UL, United Kingdom
Ashington, Northumberland Investigative Site 39017
Ashington NE63 9JJ, United Kingdom
Dudley, West Midlands Investigative Site 39018
Dudley DY1 2HQ, United Kingdom
Cardiff, Investigative Site 39015
Cardiff CF14 4XW, United Kingdom
Darlington Investigative Site 39025
Darlington DL3 6HX, United Kingdom
Durham Investigative Site 39026
Durham DH1 5TW, United Kingdom
Glasgow Investigative Site 39001
Glasgow G4 0SF, United Kingdom
Leeds, Investigative Site 39023
Leeds LS1 3EX, United Kingdom
London, Investigative Site 39016
London SE5 9RS, United Kingdom
London, Investigative Site 39002
London SW17 0QT, United Kingdom
Manchester Investigative Site 39003
Manchester M13 9WL, United Kingdom
Plymouth, Investigative Site 39014
Plymouth PL6 8DH, United Kingdom
Portadown, Investigative Site 39005
Portadown BT63 5QQ, United Kingdom
Swindon Investigative Site 39004
Swindon SN3 6BB, United Kingdom
How to Get in Touch
Marc Bonaca
Sponsor contactCONTACT
