At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- RO7566802 (drug), Atezolizumab (drug)
- How long the study runs
- Study runs about 40 months (dates as stated)
- About the drug or intervention
- RO7566802 — drug: RO7566802 solution for infusion will be administered as specified in each treatment arm. · Atezolizumab — drug: Atezolizumab solution for infusion will be administered as specified in each treatment arm.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 65
- Started
- 2023-11-27
- Last checked
- 2026-07
Plain English Summary
What is this study?
- • Testing a new treatment for locally advanced solid tumors
- • Phase1 - 65 participants
- • This is a first-in-human Phase I, open-label, dose-escalation and expansion study designed to evaluate the safety, tolerability, pharmacokinetics, immunogenicity, pharmacodynamic, and preliminary anti-tumor activity of RO7566802 as a single agent and in combination with atezolizumab in participants with locally advanced, recurrent, or metastatic incurable solid tumor malignancies
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with locally advanced solid tumors
Where?
- • Cambridge - Addenbrooke's Hospital
- • Leicester - Leicester Royal Infirmary
- • London - St Bartholomew's Hospital
- • London - Sarah Cannon Research Institute
- • +2 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This is a first-in-human Phase I, open-label, dose-escalation and expansion study designed to evaluate the safety, tolerability, pharmacokinetics, immunogenicity, pharmacodynamic, and preliminary anti-tumor activity of RO7566802 as a single agent and in combination with atezolizumab in participants with locally advanced, recurrent, or metastatic incurable solid tumor malignancies. Participants will be enrolled in 2 stages: dose escalation and expansion.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓activity scale (ECOG) Performance Status of 0-1
- ✓Life expectancy \>=3 months, in the investigator's judgment
- ✓Adequate blood and end-organ health
- ✓cancer that can be measured on scans v1.1
- ✓Tumor specimen availability, for certain cohorts
Who cannot take part
- ✗Any anti-cancer therapy, whether investigational or approved, including drug treatment, hormonal therapy, or...
- ✗Active hepatitis B or C
- ✗Active tuberculosis
- ✗Positive test for human immunodeficiency virus (HIV) infection
- ✗Administration of a live, attenuated vaccine (e.g., Flumist) within 4 weeks prior to RO7566802 infusion
See the full criteria
Where Is This Study? (6 UK sites)
Addenbrooke's Hospital
Cambridge CB2 0QQ, United Kingdom
Leicester Royal Infirmary
Leicester LE1 5WW, United Kingdom
Carolyn Maloney
uhl-tr.researchandinnovationadminmailbox@nhs.net0116 258 8351St Bartholomew's Hospital
London EC1A 7BE, United Kingdom
Sarah Cannon Research Institute
London W1G 6AD, United Kingdom
Churchill Hospital
Oxford OX3 7LJ, United Kingdom
The Royal Marsden hospital
Sutton SM2 5PT, United Kingdom
