At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Robotic Assisted Thoracic Surgery (procedure), Video Assisted Thoracic Surgery (procedure)
- How long the study runs
- Study runs about 53 months (dates as stated)
- About the drug or intervention
- Robotic Assisted Thoracic Surgery — procedure: Surgeons will pre-determine to perform a segmentectomy or lobectomy using RATS. · Video Assisted Thoracic Surgery — procedure: Surgeons will pre-determine to perform a segmentectomy or lobectomy using VATS.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Observing health over time
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 600
- Started
- 2023-07-15
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for lung cancer
- • Clinical study - 600 participants
- • To compare outcomes of minimally invasive surgical techniques for the treatment of early-stage non-small cell lung cancer
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with lung cancer
Where?
- • Bristol - University Hospitals Bristol and Weston NHS Foundation Trust
- • Coventry - University Hospitals Coventry and Warwickshire NHS Trust
- • London - Guy's and St Thomas' NHS Foundation Trust
- • London - St Bartholomew Hospital
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
To compare outcomes of minimally invasive surgical techniques for the treatment of early-stage non-small cell lung cancer.
More detail
Detection of lung cancer is occurring at increasingly earlier stages due to improved screening and the discovery of incidental nodules. Coinciding with this trend is recent data from two international randomized, control trials, RAVAL - (Robotic Lobectomy vs. Thoracoscopic Lobectomy for Early Stage Lung Cancer) and, JCOG0802 (The Japan Clinical Oncology Group) that show oncologic outcomes from segmentectomy are equivalent to lobectomy for cancers ≤2 cm. However, segmentectomy is a more complex technical operation that may not be easily feasible using video assisted thoracic surgery (VATS) but could be facilitated by robotic-assisted thoracic surgery (RATS), allowing improved vision, precision and controlled anatomic dissection. The LARCS study is designed to understand the perioperative outcomes of patients and identify the real-world selection process of either VATS and RATS segmentectomy and lobectomy for lung cancers ≤2 cm. It aims to generate evidence to support integration of patient-centered care using minimally invasive technology. In addition, health related quality of life captured in the study will also provide valuable insight into time to recovery, determining burden of the disease, and guide future treatment strategy.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓Patient diagnosed with clinical stage IA1-2 non-small cell lung cancer at time of procedure
- ✓Patient scheduled to undergo minimally invasive surgery for NSCLC with either da Vinci robotic assisted surgery or VATs
- ✓Aged ≥ 18 years
- ✓Must be willing and able to comply with study requirements
- ✓Must indicate their understanding of the study and willingness to participate by signing an appropriate informed...
Who cannot take part
- ✗Patients with clinical stage IA3, II, III, and IV lung cancer
- ✗Patient receiving a lobectomy/segmentectomy as an emergency procedure
- ✗Patients receiving a lobectomy/segmentectomy for that has spread cancer
- ✗Patients scheduled to receive a bilobectomy or sleeve-lobectomy
- ✗Mental incapacity to understand or consent to study procedures
See the full criteria
Where Is This Study? (4 UK sites)
University Hospitals Bristol and Weston NHS Foundation Trust
Bristol, United Kingdom
University Hospitals Coventry and Warwickshire NHS Trust
Coventry, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
London SE1 9RT, United Kingdom
St Bartholomew Hospital
London, United Kingdom
How to Get in Touch
Marie Allouis
Sponsor contactCONTACT
James Grainger
Sponsor contactCONTACT