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Early Discharge Pathway Registry

View on ClinicalTrials.gov ↗

At a glance

What the study gets you: Health checks and monitoring — no treatment given
Type of study: Observational (no treatment given)
Time in hospital: In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention: Not specified by the sponsor
How long the study runs: Study runs about 37 months (dates as stated)
About the drug or intervention: Not specified by the sponsor
Patient visit burden: Not specified by the sponsor

Type of study: Observing health over time
Ages: 16 Years and over
Who: All
Number of participants: 20,000
Started: 2023-11-11
Last checked: 2026-02

Plain English Summary

What is this study?

• Testing a new treatment for myocardial infarction
• Clinical study - 20,000 participants
• Despite the year-on-year decrease, coronary artery disease (CAD) still remains one of the leading causes of mortality worldwide

Who can take part?

• Ages 16 Years and over
• Diagnosed with myocardial infarction

Where?

• London - Barts Health NHS Trust
• London - Dr. Daniel Jones

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

Despite the year-on-year decrease, coronary artery disease (CAD) still remains one of the leading causes of mortality worldwide. With advances in technology and our understanding of cardiac disease, we can now treat CAD using minimally invasive interventional techniques. This has revolutionised treatment for and improved the lives of many patients with CAD. Although trials have assessed various therapeutic strategies in various populations, real-world evidence of intervention and medical treatment among patients with CAD is increasingly recognised as an important part of providing safety and efficacy data and improving the care we provide. Regional heart attack services have improved clinical outcomes following ST-segment elevation myocardial infarction (STEMI) by facilitating early reperfusion by primary percutaneous coronary intervention (PCI). Early discharge after primary PCI is welcomed by patients and increases the efficiency of health care. This data will add to that literature by assessing the characteristics and outcomes of patients with CAD, concentrating on those who are discharged via the early discharge pathway. It will also identify and characterise predictors of outcomes, and improve risk stratification and diagnostic evaluation.

More detail

The proposed study includes one of the largest coronary interventional programmes in the UK at Europe's largest cardiac centre (BHC). This has allowed us to accumulate a large number of patients in just over 4 years. All patients admitted with acute coronary syndrome and discharged via the early discharge pathway are included in this study using a clinical database. The database is password-protected and includes demographic, clinical and outcome data. The database includes patients with simple to complex CAD. We will use this database to test several hypotheses including but not limited to investigating characteristics of patients treated, complications of interventional treatment and outcomes of patients. This research will add substantially to the literature by providing real-world data from a leading coronary centre. In this registry, we will assess the safety and feasibility of the EHD pathway for patients who were discharged after primary PCI from a high-volume heart attack centre in London. The impact of this study will have local, regional and global consequences with an emphasis on investigating poorly studied areas (e.g. decompensated aortic stenosis) and providing evidence to improve their management and stimulate further research.

Myocardial InfarctionST Elevation Myocardial InfarctionNon-ST Elevation Myocardial Infarction

How this trial compares with your answers

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What we know so far

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Still need:

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

Age: 16 Years and over
Who can join: All genders

What the study is looking for

✓Both male and female patients ≥16 years of age will be included
✓All patients will have been admitted to BHC with acute coronary syndrome.

Who cannot take part

✗Patients \<16 years will not be included in this study.

See the full criteria

Inclusion Criteria: Informed consent will not be sought for, as patients are automatically included onto a database that we will use for research purposes. No children will be included in this study. Vulnerable adults or those unable to give consent will be included in the study as well if they are referred to the Interventional Cardiology team. Both male and female patients ≥16 years of age will be included All patients will have been admitted to BHC with acute coronary syndrome. Exclusion Criteria: Patients \<16 years will not be included in this study.