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Looking for participantsPhase1/Phase2

A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas

Sponsor: Bristol-Myers Squibb

NCT ID: NCT06090539

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
BMS-986458 (drug), Rituximab (drug), Glofitamab/Obinutuzumab (drug), Mosunetuzumab (drug)
How long the study runs
Study runs about 58 months (dates as stated)
About the drug or intervention
BMS-986458 — drug: Specified dose on specified days. · Rituximab — drug: Specified dose on specified days. · Glofitamab/Obinutuzumab — drug: Specified dose on specified days · Mosunetuzumab — drug: Specified dose on specified days · Epcoritamab — drug: Specified dose on specified days · Golcadomide — drug: Specified dose on specified days
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
18 Years and over
Who
All
Number of participants
460
Started
2023-12-29
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for relapsed/refractory non-hodgkin lymphoma
  • • Phase1/Phase2 - 460 participants
  • • The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with relapsed/refractory non-hodgkin lymphoma

Where?

  • • Southampton - Local Institution - 0071
  • • Manchester - Local Institution - 0081
  • • Edinburgh - Local Institution - 0072

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma.

Relapsed/Refractory Non-Hodgkin Lymphoma

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

What the study is looking for

  • ✓Participants ≥ 18 years of age with frontline or R/R NHL.
  • ✓Participants must accept and follow pregnancy prevention plan.

Who cannot take part

  • ✗Participants must not have an activity scale (ECOG) performance status ≥ 2.
  • ✗Participants with an inability to comply with listed restrictions, precautions and prohibited treatments.
  • ✗Participants must not have known or suspected central nervous system involvement.
  • ✗Other protocol-defined Inclusion/Exclusion criteria apply.
See the full criteria
Inclusion Criteria: * Participants ≥ 18 years of age with frontline or R/R NHL. * Participant must have measurable disease (defined by at least one FDG-avid lesion for FDG-avid disease and one bi-dimensionally measurable disease on cross sectional imaging by computed tomography or magnetic resonance imaging with at least one lesion \> 1.5 cm in the transverse diameter). * Participants must accept and follow pregnancy prevention plan. Exclusion Criteria: * Participants must not have an Eastern Cooperative Oncology Group (ECOG) performance status ≥ 2. * Participants with an inability to comply with listed restrictions, precautions and prohibited treatments. * Participants must not have prior CAR-T, or radiotherapy ≤ 4 weeks, systemic anticancer treatment ≤ 5 half-lives or 4 weeks, allogeneic SCT ≤ 6 months (only applicable to BMS-986458 single agent or rituximab combination cohorts), or autologous SCT ≤ 3 months prior to study intervention initiation. * In BMS-986458 + T-cell engager combination cohorts: Participants must not have prior alloSCT or solid organ transplantation, history of confirmed progressive multifocal leukoencephalopathy (PML); known or suspected history of hemophagocytic lymphohistiocytosis (HLH); known or suspected chronic active Epstein-Barr (EBV) infection. * Participants must not have any condition, including significant acute or chronic medical illness, active or uncontrolled infection, or the presence of laboratory abnormalities, that places participants at unacceptable risk if participating in this study. * Participants must not have known or suspected central nervous system involvement. * Other protocol-defined Inclusion/Exclusion criteria apply.

Where Is This Study? (3 UK sites)

Local Institution - 0071

Southampton SO16 0YD, United Kingdom

NOT_YET_RECRUITING

Local Institution - 0081

Manchester M20 4BX, United Kingdom

NOT_YET_RECRUITING

Local Institution - 0072

Edinburgh EH4 2XU, United Kingdom

NOT_YET_RECRUITING

How to Get in Touch

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

Sponsor contact

CONTACT

855-907-3286 Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #.

Sponsor contact

CONTACT

Data sourced from ClinicalTrials.gov · Last verified: 2026-09