At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- BMS-986458 (drug), Rituximab (drug), Glofitamab/Obinutuzumab (drug), Mosunetuzumab (drug)
- How long the study runs
- Study runs about 58 months (dates as stated)
- About the drug or intervention
- BMS-986458 — drug: Specified dose on specified days. · Rituximab — drug: Specified dose on specified days. · Glofitamab/Obinutuzumab — drug: Specified dose on specified days · Mosunetuzumab — drug: Specified dose on specified days · Epcoritamab — drug: Specified dose on specified days · Golcadomide — drug: Specified dose on specified days
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 460
- Started
- 2023-12-29
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for relapsed/refractory non-hodgkin lymphoma
- • Phase1/Phase2 - 460 participants
- • The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with relapsed/refractory non-hodgkin lymphoma
Where?
- • Southampton - Local Institution - 0071
- • Manchester - Local Institution - 0081
- • Edinburgh - Local Institution - 0072
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓Participants ≥ 18 years of age with frontline or R/R NHL.
- ✓Participants must accept and follow pregnancy prevention plan.
Who cannot take part
- ✗Participants must not have an activity scale (ECOG) performance status ≥ 2.
- ✗Participants with an inability to comply with listed restrictions, precautions and prohibited treatments.
- ✗Participants must not have known or suspected central nervous system involvement.
- ✗Other protocol-defined Inclusion/Exclusion criteria apply.
See the full criteria
Where Is This Study? (3 UK sites)
Local Institution - 0071
Southampton SO16 0YD, United Kingdom
Local Institution - 0081
Manchester M20 4BX, United Kingdom
Local Institution - 0072
Edinburgh EH4 2XU, United Kingdom
How to Get in Touch
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
Sponsor contactCONTACT
First line of the email MUST contain NCT # and Site #.
Sponsor contactCONTACT
