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PD Frontline (Part of RAPSODI GD) Remote Assessment of People With Parkinson's

View on ClinicalTrials.gov ↗

At a glance

What the study gets you: Health checks and monitoring — no treatment given
Type of study: Observational (no treatment given)
Time in hospital: Mix of remote tasks and in-person visits
Drug or intervention: Not specified by the sponsor
How long the study runs: Study runs about 246 months (dates as stated)
About the drug or intervention: Not specified by the sponsor
Patient visit burden: Not specified by the sponsor

Type of study: Observing health over time
Ages: 18 Years to 90 Years
Who: All
Number of participants: 4,800
Started: 2020-02-15
Last checked: 2023-11

Plain English Summary

What is this study?

• Testing a new treatment for parkinson disease
• Clinical study - 4,800 participants
• PD Frontline (part of RAPSODI GD) is an online study observational study with the goal of bringing People with Parkinson's to the frontline of research by getting them trial ready

Who can take part?

• Ages 18 Years to 90 Years
• Diagnosed with parkinson disease

Where?

• London - University College London (UCL)

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

PD Frontline (part of RAPSODI GD) is an online study observational study with the goal of bringing People with Parkinson's to the frontline of research by getting them trial ready. To do this, participants are offered genetic sequencing for the GBA and LRRK2 gene with an at-home saliva collection kit.

More detail

PD Frontline is an online one-time questionnaire based study with the purpose of identifying potential candidates for gene targeted trials and observational studies. Once the questionnaire is completed, the participant is sent a saliva collection kit in the post to provide a sample for genetic testing. The genes tested for are GBA1, the most common risk factor gene for Parkinson's, and LRRK2. Once tested, the participant is informed of their results and kept up-to-date with any studies or trials for which they may be eligible.

Parkinson Disease

How this trial compares with your answers

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What we know so far

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

Age: 18 Years - 90 Years
Who can join: All genders

Biomarkers mentioned

GBA positive

What the study is looking for

✓Formal diagnosis of Parkinson Disease

Who cannot take part

✗Confirmation that the individual carries a GBA variant (GBA positive). These individuals will be referred to...
✗History of Parkinsonism (progressive supranuclear palsy, multiple system atrophy, traumatic, manganese toxicity,...
✗Individuals with another neurological disorder including: dementia, movement disorders, and motor neurone disease.

See the full criteria

Inclusion Criteria: * Formal diagnosis of Parkinson Disease Exclusion Criteria: * Confirmation that the individual carries a GBA variant (GBA positive). These individuals will be referred to sister-study, RAPSODI. * History of Parkinsonism (progressive supranuclear palsy, multiple system atrophy, traumatic, manganese toxicity, postencephalitic, vascular PD; drug induced PD; corticobasal degeneration) * Individuals with another neurological disorder including: dementia, movement disorders, and motor neurone disease. * Individuals on drugs known to be associated with parkinsonism, including neuroleptic agents (Amisulpride, Chlorpromazine Hydrochloride, Flupenthixol, Fluphenazine Hydrochloride, Haloperidol, Methotrimeprazine, Levomepromazine, Olanzapine, Oxypertine, Pericyazine, Perphenazine, Pimozide, Pipotiazine, Prochlorperazine, Promazine Hydrochloride, Reserpine, Risperidone, Sulpiride, Thioridazine, Trifluoperazine, Zuclopenthixol acetate, Zotepine), plus Bupropion, , Lithium, Methyldopa, Metoclopramide and Sodium Valproate).

Where Is This Study? (1 UK site)

University College London (UCL)

London NW3 2PF, United Kingdom

Recruiting

Site contact (verified)

Tony SchapiraPrincipal Investigator

Orla Mitchell020 801 68413 pdfrontline@ucl.ac.uk

How to Get in Touch

Orla Mitchell

Sponsor contact

CONTACT

020 801 68413 pdfrontline@ucl.ac.uk

Data sourced from ClinicalTrials.gov · Last verified: 2023-11