At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Elranatamab (drug), Elotuzumab (drug), Pomalidomide (drug), Dexamethasone (drug)
- How long the study runs
- Study runs about 46 months (dates as stated)
- About the drug or intervention
- Elranatamab — drug: Elranatamab will be administered subcutaneously · Elotuzumab — drug: Elotuzumab will be administered intravenously · Pomalidomide — drug: Pomalidomide will be administered orally · Dexamethasone — drug: Dexamethasone will be administered orally · Bortezomib — drug: Bortezomib will be administered subcutaneously or intravenously · Carfilzomib — drug: Carfilzomib will be administered intravenously
- Patient visit burden
- Not specified by the sponsor
In plain English
This study, run by Pfizer, is testing a medicine called elranatamab in people whose multiple myeloma (a blood cancer) has come back after other treatments. Everyone in the study must already have had treatment with an anti-CD38 antibody and lenalidomide, and their disease must have got worse or not responded to their last treatment.
Who can take part
- Diagnosed with multiple myeloma and have had 1 to 4 previous courses of treatment, including an anti-CD38 antibody and lenalidomide
- Disease has got worse, or the last treatment did not work, based on standard measures
- Disease can be measured with blood or urine tests
- Blood and other laboratory test results within the range set by the study
- Able to carry out day-to-day activities at least some of the time (performance status of 2 or better on a scale used by doctors)
- Not pregnant or breastfeeding, and willing to use contraception
Who may not be able to
- Smouldering myeloma (myeloma not yet causing problems)
- Plasma cell leukaemia
- Amyloidosis
- POEMS syndrome (a rare blood disorder affecting nerves, organs, hormones and skin)
- Myeloma that has spread to the brain or spinal cord
- A stem cell transplant in the last 12 weeks, or active graft versus host disease
- An active infection that is not under control
- Another cancer in the last 3 years (with some exceptions, such as treated skin cancers)
- Previous treatment aimed at BCMA (a protein on myeloma cells) or treatment that redirects immune cells called CD3
- Not able to receive the treatment the doctor would normally choose
- A live vaccine in the last 4 weeks
- Another experimental drug or vaccine in the last 30 days
What taking part involves
- • Taking the study medicine elranatamab — not stated how it is given or how often, ask the trial team
Time commitment: Not stated — ask the trial team about how long the study lasts, how many visits are needed, and what tests or checks taking part would involve.
Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 492
- Started
- 2024-02-08
- Last checked
- 2026-08
Plain English Summary
What is this study?
- • Testing a new treatment for multiple myeloma
- • Phase3 - 492 participants
- • The purpose of this study is to learn about the study medicine called elranatamab
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with multiple myeloma
Where?
- • Milton Keynes - Milton Keynes Hospital
- • Bodelwyddan - Glan Clwyd Hospital
- • Bournemouth - Royal Bournemouth Hospital
- • Poole - Poole Hospital
- • +14 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer). This study is seeking participants who: * Are 18 years of age or older and have MM. * Have received treatments before for MM. * Have MM that has returned or not responded to their most recent treatment. Half of the participants will receive elranatamab. The other half of participants will receive a combination therapy selected by the study doctor. The selected combination therapy will include 2 to 3 different medicines commonly used to treat MM. Elranatamab will be given as a shot under the skin at the study clinic about once a week. This may change to a smaller number of shots later in the study. The medicines in the combination therapy will be taken by mouth (at home or at the study clinic) AND will be given either as: * a shot under the skin at the study clinic * through a needle in the vein at the study clinic The number of times these medicines will be taken depends on what combination therapy the study doctor selects. Participants may continue to receive elranatamab or a combination therapy until their MM is no longer responding. The study team will see how each participant is doing with the study treatment during regular visits at the study clinic. The study team will continue to follow-up with participants after study treatment with telephone contacts (or visits). The study will compare the experiences of people receiving elranatamab to those people receiving a combination therapy. This will help learn about the safety and how effective elranatamab is.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
What the study is looking for
- ✓Documented evidence of progressive disease or failure to achieve a response to last line of therapy per IMWG criteria.
- ✓Have clinical laboratory values within the specified range.
- ✓ECOG (activity scale) performance status ≤2.
- ✓Not pregnant or breastfeeding and willing to use contraception.
Who cannot take part
- ✗Smoldering multiple myeloma.
- ✗Plasma cell leukemia.
- ✗Amyloidosis.
- ✗Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin abnormalities (POEMS) syndrome.
- ✗Known central nervous system (CNS) involvement or clinical signs of myelomatous meningeal involvement.
See the full criteria
Where Is This Study? (18 UK sites)
Milton Keynes Hospital
Milton Keynes MK6 5LD, United Kingdom
Glan Clwyd Hospital
Bodelwyddan LL18 5UJ, United Kingdom
Royal Bournemouth Hospital
Bournemouth BH7 7DW, United Kingdom
Research Development & Support
clinicalresearch@bournemouth.ac.uk01202 961200Poole Hospital
Poole BH15 2JB, United Kingdom
Eastbourne District General Hospital
Eastbourne BN21 2UD, United Kingdom
Jo-Anne Taylor
esh-tr.researchanddevelopment@nhs.net0300 13 14 500 ext 771439Worthing Hospital
Worthing BN11 2DH, United Kingdom
Queen Elizabeth Hospital Birmingham
Birmingham B15 2TH, United Kingdom
Barts Health NHS Trust
London E1 1BB, United Kingdom
Betsi Cadwaladr University Health Board
Bangor LL57 2PW, United Kingdom
Maidstone Hospital
Maidstone ME16 9QQ, United Kingdom
Denise Day / Julie Knowles
mtw-tr.researchgovernance@nhs.net01622 225627St Bartholomew's Hospital
London EC1A 7BE, United Kingdom
Guy's & St Thomas' NHS Foundation Trust
London SE1 9RT, United Kingdom
King's College Hospital
London SE5 9RL, United Kingdom
Churchill Hospital
Oxford OX3 7LE, United Kingdom
Royal Stoke University Hospital
Stoke-on-Trent ST4 6QG, United Kingdom
Royal Marsden Hospital (Sutton)
London SM2 5PT, United Kingdom
Kent and Canterbury Hospital
Canterbury CT1 3NG, United Kingdom
Caroline Cowley, Research & Innovation/Clinical Trials Unit Manager
ekhuft.researchandinnovation@nhs.net01227 783169New Cross Hospital
Wolverhampton WV10 0QP, United Kingdom
How to Get in Touch
Pfizer CT.gov Call Center
Sponsor contactCONTACT
