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Looking for participantsPhase3

MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

Sponsor: Pfizer

NCT ID: NCT06152575

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Elranatamab (drug), Elotuzumab (drug), Pomalidomide (drug), Dexamethasone (drug)
How long the study runs
Study runs about 46 months (dates as stated)
About the drug or intervention
Elranatamab — drug: Elranatamab will be administered subcutaneously · Elotuzumab — drug: Elotuzumab will be administered intravenously · Pomalidomide — drug: Pomalidomide will be administered orally · Dexamethasone — drug: Dexamethasone will be administered orally · Bortezomib — drug: Bortezomib will be administered subcutaneously or intravenously · Carfilzomib — drug: Carfilzomib will be administered intravenously
Patient visit burden
Not specified by the sponsor

In plain English

This study, run by Pfizer, is testing a medicine called elranatamab in people whose multiple myeloma (a blood cancer) has come back after other treatments. Everyone in the study must already have had treatment with an anti-CD38 antibody and lenalidomide, and their disease must have got worse or not responded to their last treatment.

Who can take part

  • Diagnosed with multiple myeloma and have had 1 to 4 previous courses of treatment, including an anti-CD38 antibody and lenalidomide
  • Disease has got worse, or the last treatment did not work, based on standard measures
  • Disease can be measured with blood or urine tests
  • Blood and other laboratory test results within the range set by the study
  • Able to carry out day-to-day activities at least some of the time (performance status of 2 or better on a scale used by doctors)
  • Not pregnant or breastfeeding, and willing to use contraception

Who may not be able to

  • Smouldering myeloma (myeloma not yet causing problems)
  • Plasma cell leukaemia
  • Amyloidosis
  • POEMS syndrome (a rare blood disorder affecting nerves, organs, hormones and skin)
  • Myeloma that has spread to the brain or spinal cord
  • A stem cell transplant in the last 12 weeks, or active graft versus host disease
  • An active infection that is not under control
  • Another cancer in the last 3 years (with some exceptions, such as treated skin cancers)
  • Previous treatment aimed at BCMA (a protein on myeloma cells) or treatment that redirects immune cells called CD3
  • Not able to receive the treatment the doctor would normally choose
  • A live vaccine in the last 4 weeks
  • Another experimental drug or vaccine in the last 30 days

What taking part involves

  • • Taking the study medicine elranatamab — not stated how it is given or how often, ask the trial team

Time commitment: Not stated — ask the trial team about how long the study lasts, how many visits are needed, and what tests or checks taking part would involve.

Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.

Type of study
Testing a treatment
Ages
18 Years and over
Who
All
Number of participants
492
Started
2024-02-08
Last checked
2026-08

Plain English Summary

What is this study?

  • • Testing a new treatment for multiple myeloma
  • • Phase3 - 492 participants
  • • The purpose of this study is to learn about the study medicine called elranatamab

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with multiple myeloma

Where?

  • • Milton Keynes - Milton Keynes Hospital
  • • Bodelwyddan - Glan Clwyd Hospital
  • • Bournemouth - Royal Bournemouth Hospital
  • • Poole - Poole Hospital
  • • +14 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer). This study is seeking participants who: * Are 18 years of age or older and have MM. * Have received treatments before for MM. * Have MM that has returned or not responded to their most recent treatment. Half of the participants will receive elranatamab. The other half of participants will receive a combination therapy selected by the study doctor. The selected combination therapy will include 2 to 3 different medicines commonly used to treat MM. Elranatamab will be given as a shot under the skin at the study clinic about once a week. This may change to a smaller number of shots later in the study. The medicines in the combination therapy will be taken by mouth (at home or at the study clinic) AND will be given either as: * a shot under the skin at the study clinic * through a needle in the vein at the study clinic The number of times these medicines will be taken depends on what combination therapy the study doctor selects. Participants may continue to receive elranatamab or a combination therapy until their MM is no longer responding. The study team will see how each participant is doing with the study treatment during regular visits at the study clinic. The study team will continue to follow-up with participants after study treatment with telephone contacts (or visits). The study will compare the experiences of people receiving elranatamab to those people receiving a combination therapy. This will help learn about the safety and how effective elranatamab is.

Multiple Myeloma

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

Biomarkers mentioned

CD38CD3

What the study is looking for

  • ✓Documented evidence of progressive disease or failure to achieve a response to last line of therapy per IMWG criteria.
  • ✓Have clinical laboratory values within the specified range.
  • ✓ECOG (activity scale) performance status ≤2.
  • ✓Not pregnant or breastfeeding and willing to use contraception.

Who cannot take part

  • ✗Smoldering multiple myeloma.
  • ✗Plasma cell leukemia.
  • ✗Amyloidosis.
  • ✗Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin abnormalities (POEMS) syndrome.
  • ✗Known central nervous system (CNS) involvement or clinical signs of myelomatous meningeal involvement.
See the full criteria
Inclusion Criteria: * Prior diagnosis of multiple myeloma as defined by International Myeloma Working Group (IMWG) criteria and previously received 1 to 4 prior lines of therapy including prior anti-cluster of differentiation 38 (CD38) antibody and prior lenalidomide. * Documented evidence of progressive disease or failure to achieve a response to last line of therapy per IMWG criteria. * Measurable disease defined as at least 1 of the following: (a) Serum M-protein ≥0.5 g/dL; (b) Urinary M-protein excretion ≥200 mg/24 hours; (c) Serum involved immunoglobulin FLC ≥10 mg/dL AND abnormal serum immunoglobulin kappa to lambda FLC ratio (\<0.26 or \>1.65). * Have clinical laboratory values within the specified range. * ECOG (Eastern Cooperative Oncology Group) performance status ≤2. * Not pregnant or breastfeeding and willing to use contraception. Exclusion Criteria: * Smoldering multiple myeloma. * Plasma cell leukemia. * Amyloidosis. * Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin abnormalities (POEMS) syndrome. * Known central nervous system (CNS) involvement or clinical signs of myelomatous meningeal involvement. * Stem cell transplant within 12 weeks prior to enrolment, or active graft versus host disease. * Any active, uncontrolled bacterial, fungal, or viral infection. * Any other active malignancy within 3 years prior to enrolment (exceptions include, adequately treated basal cell or squamous cell skin cancer, carcinoma in situ) * Previous treatment with a B cell maturation antigen (BCMA)-directed therapy or CD3-redirecting therapy. * Unable to receive investigator's choice therapy. * Live attenuated vaccine within 4 weeks of the first dose of study intervention. * Administration with an investigational product (e.g. drug or vaccine) within 30 days preceding the first dose of study intervention used in this study.

Where Is This Study? (18 UK sites)

Milton Keynes Hospital

Milton Keynes MK6 5LD, United Kingdom

Recruiting
Hospital R&D contact (matched)

Antoanela Colda

Antoanela.colda@mkuh.nhs.uk01908 995119 / 01908 996651

Glan Clwyd Hospital

Bodelwyddan LL18 5UJ, United Kingdom

Recruiting

Royal Bournemouth Hospital

Bournemouth BH7 7DW, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research Development & Support

clinicalresearch@bournemouth.ac.uk01202 961200

Poole Hospital

Poole BH15 2JB, United Kingdom

Recruiting

Eastbourne District General Hospital

Eastbourne BN21 2UD, United Kingdom

Recruiting
Hospital R&D contact (matched)

Jo-Anne Taylor

esh-tr.researchanddevelopment@nhs.net0300 13 14 500 ext 771439

Worthing Hospital

Worthing BN11 2DH, United Kingdom

Recruiting
Hospital R&D contact (matched)

Scott Harfield

uhsussex.research@nhs.net01273 696955 ext. 67497

Queen Elizabeth Hospital Birmingham

Birmingham B15 2TH, United Kingdom

Recruiting
Hospital R&D contact (matched)

Sarah Pountain Head of Research Governance

R&D@uhb.nhs.uk0121 371 4185

Barts Health NHS Trust

London E1 1BB, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr Mays Jawad

research.governance@qmul.ac.uk020 7882 6826

Betsi Cadwaladr University Health Board

Bangor LL57 2PW, United Kingdom

Recruiting
Hospital R&D contact (matched)

Lona Tudor Jones

BCU.research&development@wales.nhs.uk01352 718382

Maidstone Hospital

Maidstone ME16 9QQ, United Kingdom

Recruiting
Hospital R&D contact (matched)

Denise Day / Julie Knowles

mtw-tr.researchgovernance@nhs.net01622 225627

St Bartholomew's Hospital

London EC1A 7BE, United Kingdom

Recruiting

Guy's & St Thomas' NHS Foundation Trust

London SE1 9RT, United Kingdom

Recruiting
Hospital R&D contact (matched)

Main Email: gstt.RandD@nhs.net

gstt.RandD@nhs.net---

King's College Hospital

London SE5 9RL, United Kingdom

Recruiting
Hospital R&D contact (matched)

Jasmine Palmer

kch-tr.research@nhs.net0203 299 1980

Churchill Hospital

Oxford OX3 7LE, United Kingdom

Recruiting

Royal Stoke University Hospital

Stoke-on-Trent ST4 6QG, United Kingdom

Recruiting
Hospital R&D contact (matched)

Sarah Jones

studysetup@uhnm.nhs.uk01782 675385

Royal Marsden Hospital (Sutton)

London SM2 5PT, United Kingdom

Recruiting
Hospital R&D contact (matched)

Mark Brandon-Grove

research.development@rmh.nhs.uk020 3186 5416

Kent and Canterbury Hospital

Canterbury CT1 3NG, United Kingdom

Recruiting
Hospital R&D contact (matched)

Caroline Cowley, Research & Innovation/Clinical Trials Unit Manager

ekhuft.researchandinnovation@nhs.net01227 783169

New Cross Hospital

Wolverhampton WV10 0QP, United Kingdom

Recruiting
Hospital R&D contact (matched)

Sarah Glover

rwh-tr.rdpmteam@nhs.net01902 695065

How to Get in Touch

Pfizer CT.gov Call Center

Sponsor contact

CONTACT

1-800-718-1021 ClinicalTrials.gov_Inquiries@pfizer.com
Data sourced from ClinicalTrials.gov · Last verified: 2026-08