At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Detection of obstructive coronary disease (diagnostic test)
- How long the study runs
- Study runs about 99 months (dates as stated)
- About the drug or intervention
- Detection of obstructive coronary disease — diagnostic test: Detection of obstructive coronary disease
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 2,000
- Started
- 2023-09-18
- Last checked
- 2025-10
Plain English Summary
What is this study?
- • Testing a new treatment for chronic coronary syndrome
- • NA - 2,000 participants
- • Diseases of the heart and circulation are known as cardiovascular diseases, and they cause over 160,000 deaths each year
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with chronic coronary syndrome
Where?
- • Harrow - London North West University Healthcare NHS Trust
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Diseases of the heart and circulation are known as cardiovascular diseases, and they cause over 160,000 deaths each year. Coronary heart disease (CHD) is the most common cardiovascular disease. This is due to a build-up of fatty material, known as atherosclerosis, in the blood vessels supplying blood to the heart muscle. This can cause chest pain or if blocked, can cause a heart attack. Two of the main non-invasive tests to look for coronary heart disease are Computed Tomography Coronary Angiography (CTCA) and Stress Echocardiography (Ultrasound scan). CTCA shows the arteries and allows small amounts of disease to be seen that may not yet be causing any symptoms. However, if there's lots of disease and calcification, it becomes difficult to tell how severe it is, which means several tests may be needed. Stress Echocardiography shows if enough blood is reaching the heart muscle, so can show if there is severe disease that needs treatment. However, it can't see the arteries so doesn't showt small disease that may benefit from tablet treatment. There is not yet an effective non-invasive combined test that can give all this information in one go. Studies have shown that if there's atherosclerosis in another artery, a person is very likely to have coronary atherosclerosis as well. Carotid atherosclerosis, in the neck arteries, can be seen with ultrasound similar to stress echocardiography. So, by combining these two tests the investigators want to see if it is possible to see severe as well as small areas of disease in one test, to provide better treatment. The study will enrol 2,000 participants, who need investigation for CHD, equally randomised to CTCA or stress echocardiography with carotid ultrasound. We will follow these participants for 5 years and observe for any adverse outcomes and ask them to complete a questionnaire.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ a further imaging investigation, either SE or CTCA, to evaluate a suspected diagnosis of CAD
What the study is looking for
- ✓Age \> 18 years old
- ✓Patients referred to RACPC and judged by the reviewer to require a further imaging investigation, either SE or CTCA,...
- ✓Have a PTP score ≥ 5%, as calculated using ESC guidelines OR
- ✓i) Constricting symptoms in the front of the chest or in the neck, jaw, shoulder or arm ii) Precipitated by physical...
- ✓Able to give agreement to take part to participate in the study and its follow up
Who cannot take part
- ✗Patients with diagnosed ACS that require urgent or emergency treatment or hospitalisation for inpatient investigations.
- ✗Known history of obstructive CAD (Previous MI, PCI or CABG) or previous invasive angiography with evidence of ≥ 50%...
- ✗Patients who have undergone invasive or non-invasive, functional or anatomical (Including CAC score) testing for...
- ✗Documented allergy to iodinated contrast or documented allergy to both ultrasound contrasts used at LNWH Trust;...
- ✗Contraindications to undergoing CTCA, including but not limited to;
See the full criteria
Where Is This Study? (1 UK site)
London North West University Healthcare NHS Trust
Harrow HA1 3UJ, United Kingdom
How to Get in Touch
Emma Howard
Sponsor contactCONTACT