At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Talquetamab (drug), Pomalidomide (drug), Teclistamab (drug), Elotuzumab (drug)
- How long the study runs
- Study runs about 59 months (dates as stated)
- About the drug or intervention
- Talquetamab — drug: Talquetamab will be administered as a SC injection. · Pomalidomide — drug: Pomalidomide will be administered orally. · Teclistamab — drug: Teclistamab will be administered as a SC injection. · Elotuzumab — drug: Elotuzumab will be administered intravenously. · Dexamethasone — drug: Dexamethasone will be administered either orally or intravenously. · Bortezomib — drug: Bortezomib will be administered as a SC injection.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 838
- Started
- 2024-01-22
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for multiple myeloma
- • Phase3 - 838 participants
- • The purpose of this study is to compare the effectiveness of either talquetamab plus pomalidomide (Tal-P) or talquetamab plus teclistamab (Tal-Tec) with elotuzumab, pomalidomide, and dexamethasone (EPd) or pomalidomide, bortezomib, and dexamethasone (PVd)
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with multiple myeloma
Where?
- • Blackpool - Blackpool Victoria Hospital
- • Cardiff - University Hospital of Wales
- • Dundee - Ninewells Hospital
- • Leeds - St James University Hospital
- • +4 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The purpose of this study is to compare the effectiveness of either talquetamab plus pomalidomide (Tal-P) or talquetamab plus teclistamab (Tal-Tec) with elotuzumab, pomalidomide, and dexamethasone (EPd) or pomalidomide, bortezomib, and dexamethasone (PVd).
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Treatment history
Treatments you must have had:
- ✓ or less than
What the study is looking for
- ✓Documented evidence of PD or failure to achieve a minimal response to the last line of therapy based on...
- ✓Have an activity scale (ECOG) performance status score of 0, 1, or 2 at screening and...
- ✓A participant must agree not to be pregnant, breastfeeding, or planning to become pregnant while enrolled in this...
Who cannot take part
- ✗Contraindications or life-threatening allergies, hypersensitivity, or intolerance to any the study treatment or its excipients
- ✗Stroke, transient ischemic attack, or seizure within 6 months prior to signing agreement to take part form (ICF)
- ✗A maximum cumulative dose of corticosteroids of \>=140 mg of prednisone or equivalent within 14-day period before...
See the full criteria
Where Is This Study? (8 UK sites)
Blackpool Victoria Hospital
Blackpool FY3 8NR, United Kingdom
University Hospital of Wales
Cardiff CF14 4HY, United Kingdom
Ninewells Hospital
Dundee DD1 9SY, United Kingdom
St James University Hospital
Leeds LS9 7TF, United Kingdom
Kings College Hospital
London SE5 9RS, United Kingdom
Nottingham City Hospital
Nottingham NG5 1PB, United Kingdom
University Hospitals Plymouth NHS Trust
Plymouth PL6 8DH, United Kingdom
Queen Alexandra Hospital
Portsmouth PO6 3LY, United Kingdom
