First in Human Study for the Assessment of Safety and Initial Performance of the EAS1 System

Inclusion Criteria: * Adult male and female subjects (age ≥18 years at the date of informed consent signature) * Subject is capable and willing to provide an informed consent * Subjects with a known diagnosis of lung cancer at cT1a-T1c, cN0 stages * At least one pulmonary tumor (primary or metastasis) ≤ 30 mm in maximal diameter, as confirmed by the latest standard of care imaging (CT/MRI), performed preferably up to 30 days prior to screening * Subjects who are scheduled or deemed eligible by a thoracic surgeon for lung tumor resection * Subject is able and willing to comply with the study procedures and visits * There is ≥ 5mm of nodule-free lung parenchyma between target nodule and pleura or fissure, as confirmed by the latest standard of care imaging (CT/MRI), performed preferably up to 30 days prior to screening * ECOG 0-1 * Stable doses of concomitant medications for at least four (4) weeks prior to enrollment Exclusion Criteria: * An inability to provide informed consent * Subjects with contraindication for tumor resection * Subjects with life expectancy \<12 months * Target nodule is abutting main stem bronchus, main pulmonary vasculature, esophagus and/or trachea * Subjects with Forced Expiratory Volume (FEV1) \<50% * Total Lung Capacity (TLC)\< 80% of expected for age * Diffusing Capacity (DCO) \< 60% of expected * Oxygen saturation in free air of \<88%, or requiring more than 2 l/min oxygen to achieve saturation of 92% * PCO2 of ≥ 45mm/Hg * Subjects in exacerbations group E (high risk; ≥2 exacerbations per year or ≥1 requiring hospitalization and any level of symptoms) * Severe emphysema, Bullous Emphysema or chronic obstructive pulmonary disease (COPD) (GOLD III/IV) * Active and/or prolonged lung or bronchi infection, required an antibiotic treatment up to 21 days prior to screening and for more than 10 days of treatment * Known history or current evidence of a significant bronchiectasis * Evidence of lung Bullae the occupies more than one third of the lung intended for ablation * Previous surgery in the lung intended for ablation; thoracic major surgery at the side intended for ablation * Anticoagulation treatment that cannot be discontinued prior to the ablation, or a bleeding diathesis or platelets \<100 )K/µl) * Pregnant or breastfeeding female subjects or female subjects who plan pregnancy during participation in the study * Highly hypoxemic patients, according to investigator's discretion * Subjects with implanted metal or electronic thoracic devices objects (such as pacemaker) that cannot be removed prior to procedure * Subjects with contraindication for bronchoscopy * Participation in any other interventional clinical trial with medication, medical device and/or supplements within 30 days prior to informed consent signature * Any subject who, at the discretion of the investigator, may be jeopardized by study participation