At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Dobutamine stress CMR (diagnostic test), Cardiac biomarker sample (diagnostic test)
- How long the study runs
- Study runs about 17 months (dates as stated)
- About the drug or intervention
- Dobutamine stress CMR — diagnostic test: Dobutamine stress testing will be undertaken in keeping with local departmental clinical guidelines with a graded increase in dobutamine infusion up to a maximum of 10microgram/kg/min. · Cardiac biomarker sample — diagnostic test: blood samples will be collected pre-operatively, in recovery, on post-operative days 1 and 2, and at 4-8 weeks post-operatively
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Observing health over time
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 42
- Started
- 2023-07-21
- Last checked
- 2024-06
Plain English Summary
What is this study?
- • Testing a new treatment for lung cancer
- • Clinical study - 42 participants
- • Feasibility study investigating CMR dobutamine stress testing before and after lung resection
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with lung cancer
Where?
- • Belfast - Belfast Health and Social Care Trust
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Feasibility study investigating CMR dobutamine stress testing before and after lung resection
More detail
We hypothesise that following lung resection, 1. the subtle decrease in RV function and increase in afterload we have demonstrated at rest is associated with a marked impairment of RV function on exercise, termed impaired RV contractile reserve (RVCreserve), 2. impaired RVCreserve is associated with impaired functional capacity . In this study we aim to assess the feasibility of dobutamine stress cardiovascular magnetic resonance (CMR) scanning to assess RVCreserve pre- and post-operatively in patients undergoing lung resection. Additionally, we hypothesise that one lung ventilation (with and without lung resection) is associated with biomarker evidence of RV injury.We will perform peri-operative cardiac biomarkers to differentiate between the contribution of major surgery (gastrectomy, lung resection and oesophagectomy), one lung ventilation (lung resection and oesophagectomy) and lung resection on RV injury.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓1\) Provision of agreement to take part 2) Age \>16 years 3) Planned elective
- ✓lobectomy lung resection or
- ✓oesophagectomy surgery with one lung ventilation or
- ✓gastrectomy
Who cannot take part
- ✗Pregnancy
- ✗On-going participation in any investigational research which could undermine the scientific basis of the study
- ✗Atrial fibrillation at baseline
- ✗Any safety concern to
- ✗Lung resection specific
See the full criteria
Where Is This Study? (1 UK site)
Belfast Health and Social Care Trust
Belfast BT12 6BA, United Kingdom
How to Get in Touch
Adam Glass
Sponsor contactCONTACT
Jon Silversides
Sponsor contactCONTACT