At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- DBS on/off (other)
- How long the study runs
- Study runs about 26 months (dates as stated)
- About the drug or intervention
- DBS on/off — other: DBS will be turned on and off for experimental periods to compare the effect of DBS on behaviour.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 20
- Started
- 2024-06-01
- Last checked
- 2025-03
Plain English Summary
What is this study?
- • Testing a new treatment for parkinson disease
- • NA - 20 participants
- • The goal of this experimental study with is to understand the underlying mechanisms behind the increase in impulsivity seen in some patients that undergo deep brain stimulation of the subthalamic nucleus for Parkinson's Disease
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with parkinson disease
Where?
- • Oxford - John Radcliffe Hospital
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The goal of this experimental study with is to understand the underlying mechanisms behind the increase in impulsivity seen in some patients that undergo deep brain stimulation of the subthalamic nucleus for Parkinson's Disease. The main questions it aims to answer are: What are the distributed network effects of deep brain stimulation to the subthalamic nucleus? How does this correlate with increased impulsivity? Can alternative stimulation settings be used to minimize these? Participants will complete decision-making tasks whilst their deep brain stimulation devices are turned on and off with simultaneous magnetoencephalography recordings (a type of non-invasive brain scan that measures brain activity in real-time)
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Treatment history
Treatments you must have had:
- ✓ implanted STN electrodes for DBS in addition to their dopamine replacement therapy
What the study is looking for
- ✓Participant is willing and able to give agreement to take part for participation in the study.
- ✓Male or Female, aged 18 years or above.
- ✓Diagnosed with Parkinson's disease who have required implanted STN electrodes for DBS in addition to their dopamine...
- ✓Diagnosed with or without (control group) impulse control disorders since the diagnosis of Parkinson's Disease.
- ✓Participant willing and able to sit in the MEG scanner and follow instructions.
Who cannot take part
- ✗Patients with extreme language barrier that cannot understand the purpose or instructions of the study despite the...
- ✗Other implanted medical devices that may cause artefacts during MEG recordings.
- ✗Participants with a history of co-morbid neurological disorders.
- ✗Participant enrolled onto another clinical trial related to a neurological disorder (including Parkinson's disease)...
- ✗Participants who are unable to sit still in a MEG scanner for the duration of this experiment e.g. patients with...
See the full criteria
Where Is This Study? (1 UK site)
John Radcliffe Hospital
Oxford OX39DU, United Kingdom
How to Get in Touch
John Eraifej, BSc MBChB MRCS
Sponsor contactCONTACT