At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Classical conditioning task (behavioural)
- How long the study runs
- Study runs about 27 months (dates as stated)
- About the drug or intervention
- Classical conditioning task — behavioural: To evaluate the neurophysiological and physiological response to a classical conditioning task, which is comparable to findings that have been made in the mdx dystrophic mouse (deficient in Dp427).
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Observing health over time
- Ages
- 7 Years to 17 Years
- Who
- Male
- Number of participants
- 100
- Started
- 2022-09-13
- Last checked
- 2024-08
Plain English Summary
What is this study?
- • Testing a new treatment for dmd
- • Clinical study - 100 participants
- • Study aims to develop and to evaluate the neurophysiological and physiological response to a classical conditioning task
Who can take part?
- • Ages 7 Years to 17 Years
- • Diagnosed with dmd
- • Male only
Where?
- • London - UCL GOS Institute of Child Health
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Study aims to develop and to evaluate the neurophysiological and physiological response to a classical conditioning task.To better understand how Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD) impacts mental health and how to assess it. Participants invited to complete questionnaires about behaviour, cognitive function and social interactions, complete computer tasks and have an optional MRI brain scan,
More detail
The investigation aims to develop and to evaluate the neurophysiological and physiological response to a classical conditioning task, which is comparable to findings that have been made in the mdx dystrophic mouse (deficient in Dp427). The investigators will assess correlations between the specific DMD/BMD genotype and susceptibility to conditioning, as well as the relationship between conditioning and behavioural/emotional characteristics of the syndrome. At the end of the study, the objective is to deliver a comprehensive test battery that is suitable for use in a trial of AON delivery to improve brain function.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 7 Years - 17 Years
- Who can join: Male only
What the study is looking for
- ✓DMD patients:
- ✓Age range 7-17 years
- ✓A genetically proven diagnosis of DMD.
- ✓A genetic mutation that abrogates expression of Dp427 alone (assigned in DMD Group 1: Dp427-/Dp140+) or both Dp427...
- ✓Ability to consent/assent
Who cannot take part
- ✗DMD \& BMD patients:
- ✗Significant visual or hearing impairment
- ✗Specific phobias or sensory sensitivities to stimuli similar to the ones used in this study
- ✗Current participation in a clinical trial investigating a new drug involved in dystrophin modulation.
- ✗Control participants:
See the full criteria
Where Is This Study? (1 UK site)
UCL GOS Institute of Child Health
London WC1N 1EH, United Kingdom
How to Get in Touch
Anna Kolesnik, Dr
Sponsor contactCONTACT
Natasha Aslam, MSc
Sponsor contactCONTACT
