At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- There are no interventions as the study is purely observational. (other)
- How long the study runs
- Study runs about 81 months (dates as stated)
- About the drug or intervention
- There are no interventions as the study is purely observational. — other: There are no interventions as the study is purely observational.
- Patient visit burden
- Not specified by the sponsor
In plain English
This registry collects information from people who have had spontaneous coronary artery dissection (SCAD) — a tear in the wall of one of the heart's blood vessels. It is run by the European Society of Cardiology.
Who can take part
- Adults aged 18 or over
- Have given informed consent (agreed to take part)
- Diagnosed with SCAD in the past 10 years, with heart scan images available
Who may not be able to
- People who cannot or do not want to give consent
- People whose coronary artery tear was caused by a medical procedure or by atherosclerosis (fatty build-up in the arteries)
What taking part involves
- • Not stated — ask the trial team
Time commitment: Not stated — ask the trial team
Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.
- Type of study
- Observing health over time
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 1,500
- Started
- 2021-01-30
- Last checked
- 2024-10
Plain English Summary
What is this study?
- • Testing a new treatment for spontaneous coronary artery dissection
- • Clinical study - 1,500 participants
- • Spontaneous coronary artery dissection (SCAD) is an increasingly recognised cause of non-atherosclerotic acute coronary syndromes (ACS), predominantly afflicting young women without conventional atherosclerotic risk factors
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with spontaneous coronary artery dissection
Where?
- • Ashford - William Harvey Hospital
- • Bodelwyddan - Glan Clwyd Hospital
- • Bournemouth - Bournemouth Hospital
- • Bristol - Bristol Heart Institute
- • +3 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Spontaneous coronary artery dissection (SCAD) is an increasingly recognised cause of non-atherosclerotic acute coronary syndromes (ACS), predominantly afflicting young women without conventional atherosclerotic risk factors. Knowledge of SCAD has advanced considerably in the last few years as a result of data from a number of local and national registries 1-6. Like all rarer diseases however, a better understanding of SCAD will require international collaboration. At present, there is no European or International SCAD registry despite increasing recognition that there are key differences in the diagnosis, interventional and medical management of SCAD compared with conventional atherosclerotic ACS. The ESC-ACCA Study Group on Spontaneous Coronary Artery Dissection supported by the European Observational Research Programme will now build the first pan-European SCAD registry to advance our understanding of current management of this condition, inform guidelines, educate clinical colleagues and advance research.
More detail
Observational, multicentre, international retrospective and prospective cohort study. Since this is an observational study, a formal sample size is not necessary. At least 500 prospectively recruited patients and 500 historical cases will be enrolled. Patient data will be collected at the following time-points: * First SCAD event visit (retrospectively on chart review) * First follow-up: at time of enrolment * Yearly follow-up: up to 1, 2, 3, 4 and 5 years post enrolment or until study completion Approximately 30 countries and 120 sites will participate in this registry.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓Patient having signed an agreement to take part
- ✓Patient aged 18 years and over
- ✓SCAD clinical diagnosis within the past 10 years and available coronary angiographic imagery
Who cannot take part
- ✗Patient unwilling or unable to consent
- ✗Patients with iatrogenic or atherosclerotic coronary dissection
See the full criteria
Where Is This Study? (7 UK sites)
William Harvey Hospital
Ashford, United Kingdom
Glan Clwyd Hospital
Bodelwyddan, United Kingdom
Bournemouth Hospital
Bournemouth, United Kingdom
Bristol Heart Institute
Bristol, United Kingdom
University Hospitals
Leicester, United Kingdom
Royal Brompton & Chelsea & Westminster Hospital
London, United Kingdom
Royal Free Hospital
London, United Kingdom
How to Get in Touch
Adham GHARIEB, PharmD
Sponsor contactCONTACT
Gabrielle BONNEVILLE
Sponsor contactCONTACT