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Looking for participantsPhase3

A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

NCT ID: NCT06615479

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
BMS-986393 (drug), Cyclophosphamide (drug), Fludarabine (drug), Daratumumab (drug)
How long the study runs
Study runs about 87 months (dates as stated)
About the drug or intervention
BMS-986393 — drug: Specified dose on specified days · Cyclophosphamide — drug: Specified dose on specified days · Fludarabine — drug: Specified dose on specified days · Daratumumab — drug: Specified dose on specified days · Pomalidomide — drug: Specified dose on specified days · Dexamethasone — drug: Specified dose on specified days · Carfilzomib — drug: Specified dose on specified days
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
18 Years and over
Who
All
Number of participants
440
Started
2025-03-12
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for relapsed or refractory multiple myeloma (rrmm)
  • • Phase3 - 440 participants
  • • The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with relapsed or refractory multiple myeloma (rrmm)

Where?

  • • Cambridge - Addenbrooke's Hospital
  • • London - University College London Hospital
  • • Oxford - Churchill Hospital
  • • Manchester - The Christie NHS Foundation Trust
  • • +2 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma.

Relapsed or Refractory Multiple Myeloma (RRMM)

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

Biomarkers mentioned

CD38

Treatment history

Treatments you must have had:

  • ✓ relapsed or refractory multiple myeloma (RRMM)
  • ✓ a documented diagnosis of MM as per International Myeloma Working Group Criteria
  • ✓ measurable disease during screening
  • ✓ adequate organ function

What the study is looking for

  • ✓Inclusion Criteria
  • ✓Participants must have relapsed or refractory multiple myeloma (RRMM).
  • ✓Participants must have a documented diagnosis of MM as per International Myeloma Working Group Criteria.
  • ✓Participants must have cancer that can be measured on scans during screening.
  • ✓Participants must have healthy organ.
See the full criteria
Inclusion Criteria * Participants must have relapsed or refractory multiple myeloma (RRMM). * Participants must have received at least 1 but no greater than 3 prior multiple myeloma (MM) regimens which may include a proteasome inhibitor (PI), an immunomodulatory drug (IMiD), and an anti-CD38 monoclonal antibody and have prior exposure to lenalidomide. * Participants must have a documented diagnosis of MM as per International Myeloma Working Group Criteria. * Participants must have measurable disease during screening. * Participants must have adequate organ function. * Participants must have an Eastern Cooperative Oncology group performance status 0 or 1. Exclusion Criteria * Participants must not have known active or history of central nervous system (CNS) involvement of Multiple Myeloma (MM). * Participants must not have solitary plasmacytomas or non-secretory myeloma without other evidence of measurable disease. * Participants must not need urgent treatment due to rapidly progressing MM. * Other protocol-defined Inclusion/Exclusion criteria apply.

Where Is This Study? (6 UK sites)

Addenbrooke's Hospital

Cambridge CB2 2QQ, United Kingdom

Recruiting
Site contact (verified)
Faisal Basheer, Site 018201223596275

University College London Hospital

London NW1 2PG, United Kingdom

Recruiting
Site contact (verified)
Rakesh Popat, Site 0155020 3456 7890

Churchill Hospital

Oxford OX3 7LE, United Kingdom

Recruiting
Site contact (verified)
Jaimal Kothari, Site 01570300 304 7777

The Christie NHS Foundation Trust

Manchester M20 4BX, United Kingdom

Recruiting
Site contact (verified)
Ahmed Abdulgawad, Site 0174+441614463054

Freeman Hospital

Newcastle upon Tyne NE7 7DN, United Kingdom

Recruiting
Site contact (verified)
Thomas Creasey, Site 015401912336161

Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield S10 2JF, United Kingdom

Recruiting
Site contact (verified)
Elisa Roldan Galvan, Site 020607977969791

How to Get in Touch

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

Sponsor contact

CONTACT

855-907-3286 Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #.

Sponsor contact

CONTACT

Data sourced from ClinicalTrials.gov · Last verified: 2026-09