At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- BMS-986507 (drug), Osimertinib (drug), Pembrolizumab (drug), Nivolumab (drug)
- How long the study runs
- Study runs about 72 months (dates as stated)
- About the drug or intervention
- BMS-986507 — drug: Specified dose on specified days · Osimertinib — drug: Specified dose on specified days · Pembrolizumab — drug: Specified dose on specified days · Nivolumab — drug: Specified dose on specified days · Pumitamig — drug: Specified dose on specified days
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 416
- Started
- 2025-02-04
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for lung cancer
- • Phase1/Phase2 - 416 participants
- • The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with lung cancer
Where?
- • London - Royal Free Hospital
- • Glasgow - Local Institution - 0021
- • Birmingham - University Hospitals Birmingham NHS Foundation Trust
- • Newcastle upon Tyne - Local Institution - 0001
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ at least one measurable lesion per response evaluation criteria in solid tumors
- ✓ an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
- ✓ a life expectancy of at least 3 months at the time of the first dose
- ✓ pathologically confirmed locally advanced or metastatic NSCLC
What the study is looking for
- ✓Inclusion Criteria
- ✓Participants must have at least one measurable lesion per response evaluation criteria in solid tumors.
- ✓Participants must have an activity scale (ECOG) Performance Status of 0 or 1.
- ✓Participants must have a expected to live at least 3 $2 at the time of the first dose.
- ✓Group B: Participants must have pathologically confirmed that has grown locally or that has spread NSCLC.
See the full criteria
Where Is This Study? (4 UK sites)
Royal Free Hospital
London NW32QG, United Kingdom
Local Institution - 0021
Glasgow G12 0YN, United Kingdom
University Hospitals Birmingham NHS Foundation Trust
Birmingham B15 2GW, United Kingdom
Local Institution - 0001
Newcastle upon Tyne NE7 7DN, United Kingdom
How to Get in Touch
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
Sponsor contactCONTACT
First line of the email MUST contain NCT # and Site #.
Sponsor contactCONTACT
