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Looking for participantsPhase1/Phase2

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

Sponsor: Bristol-Myers Squibb

NCT ID: NCT06618287

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
BMS-986507 (drug), Osimertinib (drug), Pembrolizumab (drug), Nivolumab (drug)
How long the study runs
Study runs about 72 months (dates as stated)
About the drug or intervention
BMS-986507 — drug: Specified dose on specified days · Osimertinib — drug: Specified dose on specified days · Pembrolizumab — drug: Specified dose on specified days · Nivolumab — drug: Specified dose on specified days · Pumitamig — drug: Specified dose on specified days
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
18 Years and over
Who
All
Number of participants
416
Started
2025-02-04
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for lung cancer
  • • Phase1/Phase2 - 416 participants
  • • The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with lung cancer

Where?

  • • London - Royal Free Hospital
  • • Glasgow - Local Institution - 0021
  • • Birmingham - University Hospitals Birmingham NHS Foundation Trust
  • • Newcastle upon Tyne - Local Institution - 0001

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.

Lung CancerBreast Cancer

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

Biomarkers mentioned

EGFRERHER2

Treatment history

Treatments you must have had:

  • ✓ at least one measurable lesion per response evaluation criteria in solid tumors
  • ✓ an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
  • ✓ a life expectancy of at least 3 months at the time of the first dose
  • ✓ pathologically confirmed locally advanced or metastatic NSCLC

What the study is looking for

  • ✓Inclusion Criteria
  • ✓Participants must have at least one measurable lesion per response evaluation criteria in solid tumors.
  • ✓Participants must have an activity scale (ECOG) Performance Status of 0 or 1.
  • ✓Participants must have a expected to live at least 3 $2 at the time of the first dose.
  • ✓Group B: Participants must have pathologically confirmed that has grown locally or that has spread NSCLC.
See the full criteria
Inclusion Criteria * Participants must have at least one measurable lesion per response evaluation criteria in solid tumors. * Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. * Participants must have a life expectancy of at least 3 months at the time of the first dose. * Group A: Participants must have pathologically confirmed locally advanced or metastatic NSCLC with an EGFR exon 19 deletion or L858R mutation in exon 21, either alone or in combination with other EGFR mutations, which may include T790M in exon 20. Participants with other EGFR mutations (including but not limited to, exon 21 L861Q, exon 18 G719X, and exon 20 S768I mutations, etc.) will also be allowed * Group B: Participants must have pathologically confirmed locally advanced or metastatic NSCLC. * Group C: Participants must have pathologically confirmed locally-advanced, recurrent inoperable, or metastatic TNBC or ER-low, HER2-negative BC. * Group D: Participants must have pathologically confirmed locally-advanced, recurrent inoperable, or metastatic TNBC per ASCO/CAP criteria, based on the most recently analyzed biopsy or another pathology specimen. * Group E: Participants must have pathologically confirmed locally advanced or metastatic NSCLC, not amenable to treatment in curative intent. Exclusion Criteria * Participants must not have any mixed Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC) histology. * Participants with known mutations in EGFR will be excluded (Group A,B and E). * Participants must not have a history of serious recurrent infections. * Participants must not have a history of severe heart disease. * Other protocol-defined Inclusion/Exclusion criteria apply.

Where Is This Study? (4 UK sites)

Royal Free Hospital

London NW32QG, United Kingdom

Recruiting
Site contact (verified)
Alexa Childs, Site 0030442077040500

Local Institution - 0021

Glasgow G12 0YN, United Kingdom

NOT_YET_RECRUITING

University Hospitals Birmingham NHS Foundation Trust

Birmingham B15 2GW, United Kingdom

Recruiting
Site contact (verified)
Gary Middleton, Site 0020441214158237

Local Institution - 0001

Newcastle upon Tyne NE7 7DN, United Kingdom

NOT_YET_RECRUITING

How to Get in Touch

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

Sponsor contact

CONTACT

855-907-3286 Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #.

Sponsor contact

CONTACT

Data sourced from ClinicalTrials.gov · Last verified: 2026-09