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A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

View on ClinicalTrials.gov ↗

At a glance

What the study gets you: Access to the study treatment being tested
Type of study: Interventional (receives a drug or procedure)
Time in hospital: In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention: JNJ-81201887 (drug), Sham Procedure (other)
How long the study runs: Study runs about 70 months (dates as stated)
About the drug or intervention: JNJ-81201887 — drug: No study intervention will be administered as part of this LTE study. · Sham Procedure — other: No study intervention will be administered as part of this LTE study.
Patient visit burden: Not specified by the sponsor

Type of study: Testing a treatment
Ages: 60 Years and over
Who: All
Number of participants: 274
Started: 2024-09-19
Last checked: 2026-09

Plain English Summary

What is this study?

• Testing a new treatment for geographic atrophy
• Phase2/Phase3 - 274 participants
• The purpose of this study is to assess the long-term safety and tolerability after an intravitreal injection (a shot of medicine into the eye) of JNJ-81201887 administered in parent clinical studies

Who can take part?

• Ages 60 Years and over
• Diagnosed with geographic atrophy

Where?

• Bristol - Bristol Eye Hospital
• Headington - Oxford Eye Hospital
• London - The Retina Clinic London
• Newcastle upon Tyne - Royal Victoria Infirmary

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this study is to assess the long-term safety and tolerability after an intravitreal injection (a shot of medicine into the eye) of JNJ-81201887 administered in parent clinical studies.

Geographic AtrophyMacular Degeneration

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search

Age· Tell us your age for better matching

Gender· Tell us your sex for better matching

Still need:

• Tell us your age for better matching
• Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

Age: 60 Years and over
Who can join: All genders

Treatment history

Treatments you must have had:

✓ to use contraception in this LTE study
✓ for, the study and is willing to participate in the study

What the study is looking for

✓Participants who were enrolled and received treatment with JNJ-81201887 or sham in a parent clinical study...
✓Females (women of childbearing potential), male participants, and partners of male participants will not be required...

Who cannot take part

✗There are no exclusion criteria for this LTE study

See the full criteria

Inclusion Criteria: * Participants who were enrolled and received treatment with JNJ-81201887 or sham in a parent clinical study (81201887MDG2001, 81201887MDG1003) * Females (women of childbearing potential), male participants, and partners of male participants will not be required to use contraception in this LTE study * Must sign an informed consent form (ICF) indicating that participant understands the purpose of, and procedures required for, the study and is willing to participate in the study. The ICF may be signed by an impartial witness and/or legally designated representative depending on national/local regulations Exclusion Criteria: * There are no exclusion criteria for this LTE study

Where Is This Study? (4 UK sites)

Bristol Eye Hospital

Bristol BS1 2LX, United Kingdom

ACTIVE_NOT_RECRUITING

Oxford Eye Hospital

Headington OX3 9DU, United Kingdom

ACTIVE_NOT_RECRUITING

Hospital R&D contact (matched)

Shahista Hussain

ouhtma@ouh.nhs.uk ---

The Retina Clinic London

London W1G 9AX, United Kingdom

ACTIVE_NOT_RECRUITING

Royal Victoria Infirmary

Newcastle upon Tyne NE1 4LP, United Kingdom

COMPLETED

Hospital R&D contact (matched)

Colleen Bowthorpe

colleen.bowthorpe@nhs.scot 01387 241815

How to Get in Touch

Study Contact

Sponsor contact

CONTACT

844-434-4210 Participate-In-This-Study1@its.jnj.com

Data sourced from ClinicalTrials.gov · Last verified: 2026-09