At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Rimegepant (drug), Placebo Comparator (drug), Standard of Care (drug), Rimegepant (drug)
- How long the study runs
- Study runs about 24 months (dates as stated)
- About the drug or intervention
- Rimegepant — drug: Rimegepant 75 mg ODT for 7 days · Placebo Comparator — drug: Matching placebo oral disintegrating tablets for 7 days · Standard of Care — drug: Standard of care for acute treatment as needed · Rimegepant — drug: Rimegepant 75 mg ODT for acute treatment as needed
- Patient visit burden
- Not specified by the sponsor
In plain English
This study, run by Pfizer, is testing a medicine called rimegepant in women to see if it can help prevent menstrual migraine when taken from time to time rather than every day. Menstrual migraine is a migraine attack linked to a woman's period.
Who can take part
- You have regular periods, with cycles between 24 and 34 days.
- You have had migraine (with or without warning signs called aura) for at least 1 year.
- You have had menstrual migraine attacks for at least 3 months.
- You had at least 1 migraine attack around your period in at least 2 of your last 3 periods before joining the study.
- If you take a daily medicine to prevent migraine, the dose must have been the same for at least 3 months and must not change during the study.
Who may not be able to
- You have more than 6 migraine days a month outside the time around your period in the past 3 months.
- You have chronic migraine or more than 14 headache days a month on average in the past 3 months.
- You have had certain rare migraine types affecting the eye, vision at the back of the head, or causing weakness on one side of the body.
- You have schizophrenia, bipolar disorder, or borderline personality disorder.
- You have other long-term pain conditions (such as fibromyalgia), significant nerve or brain conditions other than migraine, or other medical conditions, including hormone or gynaecological problems such as severe period pain.
What taking part involves
- • Not stated — ask the trial team
Time commitment: Not stated — ask the trial team
Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.
- Type of study
- Testing a treatment
- Ages
- 18 Years to 45 Years
- Who
- Female
- Number of participants
- 723
- Started
- 2025-03-11
- Last checked
- 2026-07
Plain English Summary
What is this study?
- • Testing a new treatment for menstrual migraine
- • Phase3 - 723 participants
- • The purpose of this study is to evaluate the efficacy and safety of rimegepant when administered during the peri-menstrual period (PMP) for intermittent prevention of migraine in women who experience menstrual migraine attacks
Who can take part?
- • Ages 18 Years to 45 Years
- • Diagnosed with menstrual migraine
- • Female only
Where?
- • Bristol - West Walk Surgery
- • Milton Keynes - Bioluminux
- • Hull - Hull University Teaching Hospitals NHS Trust
- • London - Re:Cognition Health - London
- • +4 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The purpose of this study is to evaluate the efficacy and safety of rimegepant when administered during the peri-menstrual period (PMP) for intermittent prevention of migraine in women who experience menstrual migraine attacks.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years - 45 Years
- Who can join: Female only
What the study is looking for
- ✓Participant has regular menstrual cycles ≥24 days and ≤34 days
- ✓A minimum 1-year history of migraine (with or without aura) consistent with a diagnosis according to the...
- ✓A history of menstrual migraine attacks of at least 3 months
- ✓Participant reported history of experiencing at least 1 migraine attack during the perimenstrual period in at least...
Who cannot take part
- ✗Greater than 6 migraine days per month that are outside of the perimenstrual period in the 3 months prior to Screening
- ✗A diagnosis of chronic migraine or a history of more than 14 headache days per month on average, in the 3 months...
- ✗History of retinal migraine, basilar migraine or hemiplegic migraine
- ✗Current diagnosis of schizophrenia, bipolar, or borderline personality disorder
See the full criteria
Where Is This Study? (8 UK sites)
West Walk Surgery
Bristol BS37 4AX, United Kingdom
Bioluminux
Milton Keynes MK15 0DU, United Kingdom
Hull University Teaching Hospitals NHS Trust
Hull HU3 2JZ, United Kingdom
James Illingworth
hyp-tr.development.research@nhs.net01482 461883 or 461903Re:Cognition Health - London
London W1G 8TA, United Kingdom
The Walton Centre NHS Foundation Trust
Fazakerley L9 7LJ, United Kingdom
Panthera Clinic - York
York YO24 4LJ, United Kingdom
Panthera Biopartners - Glasgow
Glasgow G51 4TY, United Kingdom
Panthera Biopartners - Sheffield
Sheffield S2 5FX, United Kingdom
How to Get in Touch
Pfizer CT.gov Call Center
Sponsor contactCONTACT
