At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Amivantamab (drug), Lazertinib (drug), Chemotherapy: Pemetrexed (drug), Chemotherapy: Carboplatin (drug)
- How long the study runs
- Study runs about 72 months (dates as stated)
- About the drug or intervention
- Amivantamab — drug: Amivantamab will be administered. · Lazertinib — drug: Lazertinib tablet will be administered. · Chemotherapy: Pemetrexed — drug: Pemetrexed will be administered. · Chemotherapy: Carboplatin — drug: Carboplatin will be administered.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 480
- Started
- 2024-12-16
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for carcinoma, non-small-cell lung
- • Phase2 - 480 participants
- • The primary purpose of the study is to assess how well amivantamab in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC; that is one of the major types of lung cancer)
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with carcinoma, non-small-cell lung
Where?
- • Greater London - Guy's and St Thomas' NHS Foundation Trust
- • Liverpool - The Clatterbridge Cancer Centre NHS Foundation Trust
- • London - Royal Marsden Hospital 1
- • Manchester - The Christie NHS Foundation Trust Christie Hospital
- • +2 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The primary purpose of the study is to assess how well amivantamab in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC; that is one of the major types of lung cancer).
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓Have confirmed by testing a sample advanced or that has spread non-small cell lung cancer (NSCLC) that is not...
- ✓Have at least 1 measurable lesion, according to RECIST version (v)1.1, that has not been previously irradiated
- ✓Have an activity scale (ECOG) performance status of 0 to 1
Who cannot take part
- ✗Participant has uncontrolled tumor-related pain (causing symptoms lesions amenable to palliative radiotherapy should be...
See the full criteria
Where Is This Study? (6 UK sites)
Guy's and St Thomas' NHS Foundation Trust
Greater London SE1 9RT, United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust
Liverpool L78YA, United Kingdom
Royal Marsden Hospital 1
London SW3 6JJ, United Kingdom
The Christie NHS Foundation Trust Christie Hospital
Manchester M20 4BX, United Kingdom
Royal Marsden Hospital
Sutton SM2 5PT, United Kingdom
Torbay Hospital-Devon
Torquay TQ2 7AA, United Kingdom
How to Get in Touch
Study Contact
Sponsor contactCONTACT
