At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- ABBV-291 (drug)
- How long the study runs
- Study runs about 82 months (dates as stated)
- About the drug or intervention
- ABBV-291 — drug: Intravenous Infusion
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 21
- Started
- 2025-01-16
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for non-hodgkin's lymphoma
- • Phase1 - 21 participants
- • Non-Hodgkin's lymphoma (NHL) is a cancer that arises from the transformation of normal B and T lymphocytes (white blood cells)
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with non-hodgkin's lymphoma
Where?
- • Manchester - The Christie /ID# 267177
- • Plymouth - University Hospitals Plymouth NHS Trust /ID# 267174
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Non-Hodgkin's lymphoma (NHL) is a cancer that arises from the transformation of normal B and T lymphocytes (white blood cells). The purpose of this study is to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of ABBV-291 in adult participants in relapsed or refractory (R/R) NHL, including but not limited to diffuse large b-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and follicular lymphoma (FL). Adverse events will be assessed. ABBV-291 is an investigational drug being developed for the treatment of NHL. This study will include a dose escalation phase to determine the maximum administered dose (MAD)/Maximum tolerated dose (MTD) of ABBV-291 and a dose expansion/optimization phase to determine the change in disease activity in participants with R/R NHL. Approximately 165 adult participants with multiple NHL subtypes will be enrolled in the study in sites world wide In the dose escalation phase of the study participants will receive escalating Intravenously (IV) infused doses of ABBV-291, until the MAD/MTD is determined. In the dose expansion/optimization phase of the study participants receive IV infused ABBV-291, as part of the approximately 74 month study duration. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, and side effects.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓Mantle cell lymphoma (MCL);
- ✓Marginal zone lymphoma (MZL);
- ✓Waldenstrom macroglobulinemia (WM);
- ✓FL Grades 1 to 3B;
- ✓Part 2b only: FL Grades 1 to 3B;
Who cannot take part
- ✗History of interstitial lung disease (ILD) or pneumonitis that required treatment with systemic steroids, or any...
- ✗Treatment with any of the following:
- ✗CD79b-directed agents (e.g., CD79b monoclonal antibody therapy) within 4 weeks (or at least 5 half-lives, whichever...
- ✗Prior treatment with an antibody drug conjugate that consists of a topoisomerase I inhibitor.
See the full criteria
Where Is This Study? (2 UK sites)
The Christie /ID# 267177
Manchester M20 4BX, United Kingdom
University Hospitals Plymouth NHS Trust /ID# 267174
Plymouth PL6 5FP, United Kingdom
